Rapid Screening for C3435t Polymorphism in Exon 26 of the Multi-Drug Resistance (MDR1) Gene in Malay Patients with Acute Leukemia
The over expression of P-glycoprotein has been found to be associated with therapy resistance in hematological malignancies including acute leukemias. Recently, a single nucleotide polymorphism (SNP) in exon 26 (C3435T) in the MDR1 gene has shown to have functional consequences with altered expre...
| Main Author: | |
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| Format: | Article |
| Language: | English |
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Penerbit Universiti Sains Malaysia
2005
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| Online Access: | http://eprints.usm.my/29260/ http://eprints.usm.my/29260/1/badrulyahaya2005.pdf |
| _version_ | 1848876056251990016 |
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| author | Yahaya, Badrul Hisham |
| author_facet | Yahaya, Badrul Hisham |
| author_sort | Yahaya, Badrul Hisham |
| building | USM Institutional Repository |
| collection | Online Access |
| description | The over expression of P-glycoprotein has been found to be associated
with therapy resistance in hematological malignancies including acute leukemias.
Recently, a single nucleotide polymorphism (SNP) in exon 26 (C3435T) in the MDR1
gene has shown to have functional consequences with altered expression of P-gp.
Denaturing HPLC has been established as a rapid method for screening SNP in the
form of heteroduplex of the DNA samples under partially denaturing condition. |
| first_indexed | 2025-11-15T16:53:29Z |
| format | Article |
| id | usm-29260 |
| institution | Universiti Sains Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T16:53:29Z |
| publishDate | 2005 |
| publisher | Penerbit Universiti Sains Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | usm-292602017-09-01T10:46:43Z http://eprints.usm.my/29260/ Rapid Screening for C3435t Polymorphism in Exon 26 of the Multi-Drug Resistance (MDR1) Gene in Malay Patients with Acute Leukemia Yahaya, Badrul Hisham R5-920 Medicine (General) The over expression of P-glycoprotein has been found to be associated with therapy resistance in hematological malignancies including acute leukemias. Recently, a single nucleotide polymorphism (SNP) in exon 26 (C3435T) in the MDR1 gene has shown to have functional consequences with altered expression of P-gp. Denaturing HPLC has been established as a rapid method for screening SNP in the form of heteroduplex of the DNA samples under partially denaturing condition. Penerbit Universiti Sains Malaysia 2005 Article PeerReviewed application/pdf en cc_by http://eprints.usm.my/29260/1/badrulyahaya2005.pdf Yahaya, Badrul Hisham (2005) Rapid Screening for C3435t Polymorphism in Exon 26 of the Multi-Drug Resistance (MDR1) Gene in Malay Patients with Acute Leukemia. The Malaysian Journal of Medical Sciences, 12 (1). p. 61. ISSN 1394-195X http://journal.usm.my/journal/10th%20ncms%20oral%20-%20supp%202005.pdf |
| spellingShingle | R5-920 Medicine (General) Yahaya, Badrul Hisham Rapid Screening for C3435t Polymorphism in Exon 26 of the Multi-Drug Resistance (MDR1) Gene in Malay Patients with Acute Leukemia |
| title | Rapid Screening for C3435t Polymorphism in Exon 26 of the Multi-Drug Resistance (MDR1) Gene in Malay Patients with Acute Leukemia |
| title_full | Rapid Screening for C3435t Polymorphism in Exon 26 of the Multi-Drug Resistance (MDR1) Gene in Malay Patients with Acute Leukemia |
| title_fullStr | Rapid Screening for C3435t Polymorphism in Exon 26 of the Multi-Drug Resistance (MDR1) Gene in Malay Patients with Acute Leukemia |
| title_full_unstemmed | Rapid Screening for C3435t Polymorphism in Exon 26 of the Multi-Drug Resistance (MDR1) Gene in Malay Patients with Acute Leukemia |
| title_short | Rapid Screening for C3435t Polymorphism in Exon 26 of the Multi-Drug Resistance (MDR1) Gene in Malay Patients with Acute Leukemia |
| title_sort | rapid screening for c3435t polymorphism in exon 26 of the multi-drug resistance (mdr1) gene in malay patients with acute leukemia |
| topic | R5-920 Medicine (General) |
| url | http://eprints.usm.my/29260/ http://eprints.usm.my/29260/ http://eprints.usm.my/29260/1/badrulyahaya2005.pdf |