Rapid Screening for C3435t Polymorphism in Exon 26 of the Multi-Drug Resistance (MDR1) Gene in Malay Patients with Acute Leukemia
The over expression of P-glycoprotein has been found to be associated with therapy resistance in hematological malignancies including acute leukemias. Recently, a single nucleotide polymorphism (SNP) in exon 26 (C3435T) in the MDR1 gene has shown to have functional consequences with altered expre...
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| Format: | Article |
| Language: | English |
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Penerbit Universiti Sains Malaysia
2005
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| Online Access: | http://eprints.usm.my/29260/ http://eprints.usm.my/29260/1/badrulyahaya2005.pdf |
| Summary: | The over expression of P-glycoprotein has been found to be associated
with therapy resistance in hematological malignancies including acute leukemias.
Recently, a single nucleotide polymorphism (SNP) in exon 26 (C3435T) in the MDR1
gene has shown to have functional consequences with altered expression of P-gp.
Denaturing HPLC has been established as a rapid method for screening SNP in the
form of heteroduplex of the DNA samples under partially denaturing condition. |
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