Diagnostic pitfalls of metastatic lobular breast carcinoma to the endometrium in a patient on long-standing tamoxifen therapy
Metastatic carcinoma from extragenital sites to the uterus, particularly the endometrium, is rare and usually a sign of advanced disease. It is necessary to differentiate between metastatic and primary tumours since the treatment and prognosis are entirely different. We discuss a case of a 61-year-o...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Faculty of Medicine and Health Sciences, Universiti Putra Malaysia
2022
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| Online Access: | http://psasir.upm.edu.my/id/eprint/99331/ http://psasir.upm.edu.my/id/eprint/99331/1/2022121913024722_MJMHS_0510.pdf |
| _version_ | 1848863103919325184 |
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| author | Chew, Pong Keong Lai, Shau Kong Mohd Ali, Razana Hussin, Huzlinda |
| author_facet | Chew, Pong Keong Lai, Shau Kong Mohd Ali, Razana Hussin, Huzlinda |
| author_sort | Chew, Pong Keong |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Metastatic carcinoma from extragenital sites to the uterus, particularly the endometrium, is rare and usually a sign of advanced disease. It is necessary to differentiate between metastatic and primary tumours since the treatment and prognosis are entirely different. We discuss a case of a 61-year-old woman who presented with postmenopausal bleeding due to metastatic breast cancer to the endometrium. She had been diagnosed with breast cancer and on tamoxifen for six years. This case highlights the possibility of isolated breast cancer metastasis to the endometrium without ovarian involvement and the overlapping histological features due to tamoxifen therapy. Abnormal uterine bleeding in a case of breast cancer should raise the suspicion of metastatic breast disease. The immunohistochemical study is critical to support the microscopic findings in conjunction with clinical history and radiological findings. |
| first_indexed | 2025-11-15T13:27:36Z |
| format | Article |
| id | upm-99331 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T13:27:36Z |
| publishDate | 2022 |
| publisher | Faculty of Medicine and Health Sciences, Universiti Putra Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-993312023-03-13T02:07:00Z http://psasir.upm.edu.my/id/eprint/99331/ Diagnostic pitfalls of metastatic lobular breast carcinoma to the endometrium in a patient on long-standing tamoxifen therapy Chew, Pong Keong Lai, Shau Kong Mohd Ali, Razana Hussin, Huzlinda Metastatic carcinoma from extragenital sites to the uterus, particularly the endometrium, is rare and usually a sign of advanced disease. It is necessary to differentiate between metastatic and primary tumours since the treatment and prognosis are entirely different. We discuss a case of a 61-year-old woman who presented with postmenopausal bleeding due to metastatic breast cancer to the endometrium. She had been diagnosed with breast cancer and on tamoxifen for six years. This case highlights the possibility of isolated breast cancer metastasis to the endometrium without ovarian involvement and the overlapping histological features due to tamoxifen therapy. Abnormal uterine bleeding in a case of breast cancer should raise the suspicion of metastatic breast disease. The immunohistochemical study is critical to support the microscopic findings in conjunction with clinical history and radiological findings. Faculty of Medicine and Health Sciences, Universiti Putra Malaysia 2022-12 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/99331/1/2022121913024722_MJMHS_0510.pdf Chew, Pong Keong and Lai, Shau Kong and Mohd Ali, Razana and Hussin, Huzlinda (2022) Diagnostic pitfalls of metastatic lobular breast carcinoma to the endometrium in a patient on long-standing tamoxifen therapy. Malaysian Journal of Medicine and Health Sciences, 18 (supp.21). pp. 137-139. ISSN 2636-9346 https://medic.upm.edu.my/upload/dokumen/2022121913024722_MJMHS_0510.pdf 10.47836/mjmhs18.s21.23 |
| spellingShingle | Chew, Pong Keong Lai, Shau Kong Mohd Ali, Razana Hussin, Huzlinda Diagnostic pitfalls of metastatic lobular breast carcinoma to the endometrium in a patient on long-standing tamoxifen therapy |
| title | Diagnostic pitfalls of metastatic lobular breast carcinoma to the endometrium in a patient on long-standing tamoxifen therapy |
| title_full | Diagnostic pitfalls of metastatic lobular breast carcinoma to the endometrium in a patient on long-standing tamoxifen therapy |
| title_fullStr | Diagnostic pitfalls of metastatic lobular breast carcinoma to the endometrium in a patient on long-standing tamoxifen therapy |
| title_full_unstemmed | Diagnostic pitfalls of metastatic lobular breast carcinoma to the endometrium in a patient on long-standing tamoxifen therapy |
| title_short | Diagnostic pitfalls of metastatic lobular breast carcinoma to the endometrium in a patient on long-standing tamoxifen therapy |
| title_sort | diagnostic pitfalls of metastatic lobular breast carcinoma to the endometrium in a patient on long-standing tamoxifen therapy |
| url | http://psasir.upm.edu.my/id/eprint/99331/ http://psasir.upm.edu.my/id/eprint/99331/ http://psasir.upm.edu.my/id/eprint/99331/ http://psasir.upm.edu.my/id/eprint/99331/1/2022121913024722_MJMHS_0510.pdf |