Lymphoplasmacytic lymphoma with paraprotein IgG
Lymphoplasmacytic lymphoma (LPL) is a rare indolent mature B-cell lymphoma. LPL secreting immunoglobulins other than IgM are rare. There are very few case series on non-IgM LPL, and little is known about the clinical features and outcomes of patients with this disease. We report the case of a 65-yea...
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| Format: | Article |
| Language: | English |
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Faculty of Medicine and Health Sciences, Universiti Putra Malaysia
2022
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| Online Access: | http://psasir.upm.edu.my/id/eprint/99321/ http://psasir.upm.edu.my/id/eprint/99321/1/2022121912532320_MJMHS_0298.pdf |
| _version_ | 1848863101222387712 |
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| author | Mat Yusuf, Shaidatina Mohd Tohit, Eusni Rahayu Nahanthiran, Subithira |
| author_facet | Mat Yusuf, Shaidatina Mohd Tohit, Eusni Rahayu Nahanthiran, Subithira |
| author_sort | Mat Yusuf, Shaidatina |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Lymphoplasmacytic lymphoma (LPL) is a rare indolent mature B-cell lymphoma. LPL secreting immunoglobulins other than IgM are rare. There are very few case series on non-IgM LPL, and little is known about the clinical features and outcomes of patients with this disease. We report the case of a 65-year-old-male who was referred to our hospital for further investigations of persistent chronic anaemia and was diagnosed with IgG-LPL based on the presence of M protein from serum electrophoresis. Bone marrow morphology exhibit a spectrum of B-cell differentiation ranging from small mature lymphocytes to plasma cells. The patient underwent treatment with a combination of bortezomib, dexamethasone and rituximab and showed positive response. LPL with paraprotein IgG is a rare indolent disease and has a heterogeneous clinicopathological presentation with limited literature reviews. Our case report and literature review provide insights and knowledge in the description of the clinicopathological features of IgG LPL. |
| first_indexed | 2025-11-15T13:27:34Z |
| format | Article |
| id | upm-99321 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T13:27:34Z |
| publishDate | 2022 |
| publisher | Faculty of Medicine and Health Sciences, Universiti Putra Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-993212023-03-09T07:06:05Z http://psasir.upm.edu.my/id/eprint/99321/ Lymphoplasmacytic lymphoma with paraprotein IgG Mat Yusuf, Shaidatina Mohd Tohit, Eusni Rahayu Nahanthiran, Subithira Lymphoplasmacytic lymphoma (LPL) is a rare indolent mature B-cell lymphoma. LPL secreting immunoglobulins other than IgM are rare. There are very few case series on non-IgM LPL, and little is known about the clinical features and outcomes of patients with this disease. We report the case of a 65-year-old-male who was referred to our hospital for further investigations of persistent chronic anaemia and was diagnosed with IgG-LPL based on the presence of M protein from serum electrophoresis. Bone marrow morphology exhibit a spectrum of B-cell differentiation ranging from small mature lymphocytes to plasma cells. The patient underwent treatment with a combination of bortezomib, dexamethasone and rituximab and showed positive response. LPL with paraprotein IgG is a rare indolent disease and has a heterogeneous clinicopathological presentation with limited literature reviews. Our case report and literature review provide insights and knowledge in the description of the clinicopathological features of IgG LPL. Faculty of Medicine and Health Sciences, Universiti Putra Malaysia 2022-12 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/99321/1/2022121912532320_MJMHS_0298.pdf Mat Yusuf, Shaidatina and Mohd Tohit, Eusni Rahayu and Nahanthiran, Subithira (2022) Lymphoplasmacytic lymphoma with paraprotein IgG. Malaysian Journal of Medicine and Health Sciences, 18 (supp.21). pp. 130-133. ISSN 2636-9346 https://medic.upm.edu.my/upload/dokumen/2022121912532320_MJMHS_0298.pdf 10.47836/mjmhs18.s21.21 |
| spellingShingle | Mat Yusuf, Shaidatina Mohd Tohit, Eusni Rahayu Nahanthiran, Subithira Lymphoplasmacytic lymphoma with paraprotein IgG |
| title | Lymphoplasmacytic lymphoma with paraprotein IgG |
| title_full | Lymphoplasmacytic lymphoma with paraprotein IgG |
| title_fullStr | Lymphoplasmacytic lymphoma with paraprotein IgG |
| title_full_unstemmed | Lymphoplasmacytic lymphoma with paraprotein IgG |
| title_short | Lymphoplasmacytic lymphoma with paraprotein IgG |
| title_sort | lymphoplasmacytic lymphoma with paraprotein igg |
| url | http://psasir.upm.edu.my/id/eprint/99321/ http://psasir.upm.edu.my/id/eprint/99321/ http://psasir.upm.edu.my/id/eprint/99321/ http://psasir.upm.edu.my/id/eprint/99321/1/2022121912532320_MJMHS_0298.pdf |