A case of angiomatoid epithelioid sarcoma mimicking an epithelioid vascular neoplasm
Epithelioid sarcoma is a rare but aggressive soft tissue sarcoma that presents a significant diagnostic and manage- ment challenge to clinicians. We report a 31-year-old female who presented with a non-healing ulcer of three years’ duration on her left thumb after a burn. Examination revealed an ulc...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Faculty of Medicine and Health Sciences, Universiti Putra Malaysia
2022
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| Online Access: | http://psasir.upm.edu.my/id/eprint/99319/ http://psasir.upm.edu.my/id/eprint/99319/1/2022121912513218_MJMHS_0388.pdf |
| _version_ | 1848863100687613952 |
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| author | Lai, Shau Kong Tan, Ling Tze Tan, Lii Jye Koh, Cai Ping Yahaya, Balqis Hussin, Huzlinda |
| author_facet | Lai, Shau Kong Tan, Ling Tze Tan, Lii Jye Koh, Cai Ping Yahaya, Balqis Hussin, Huzlinda |
| author_sort | Lai, Shau Kong |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Epithelioid sarcoma is a rare but aggressive soft tissue sarcoma that presents a significant diagnostic and manage- ment challenge to clinicians. We report a 31-year-old female who presented with a non-healing ulcer of three years’ duration on her left thumb after a burn. Examination revealed an ulcerative tumour invading the bone with areas of haemorrhage. Microscopic examination showed an epithelioid neoplasm with central necrosis. The neoplastic cells formed dyscohesive sheets, slit-like channels, and pseudovascular spaces. Erythrocytes were frequently observed in these areas. The neoplastic malignant cells were diffusely positive for cytokeratin AE1/AE3, EMA, vimentin, Fli-1; while focally positive for CD34 and CD31. The morphology and immunophenotype overlap with a vascular neo- plasm. Additional immunohistochemical stain revealed loss of SMARCB1/INI1 expression supporting the diagnosis of epithelioid sarcoma of distal type, angiomatoid variant. We present a distinctive case of angiomatoid epithelioid sarcoma that developed in a burn ulcer and highlight pathological characteristics that distinguish it from epithelioid vascular neoplasms. |
| first_indexed | 2025-11-15T13:27:33Z |
| format | Article |
| id | upm-99319 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T13:27:33Z |
| publishDate | 2022 |
| publisher | Faculty of Medicine and Health Sciences, Universiti Putra Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-993192023-03-09T03:30:13Z http://psasir.upm.edu.my/id/eprint/99319/ A case of angiomatoid epithelioid sarcoma mimicking an epithelioid vascular neoplasm Lai, Shau Kong Tan, Ling Tze Tan, Lii Jye Koh, Cai Ping Yahaya, Balqis Hussin, Huzlinda Epithelioid sarcoma is a rare but aggressive soft tissue sarcoma that presents a significant diagnostic and manage- ment challenge to clinicians. We report a 31-year-old female who presented with a non-healing ulcer of three years’ duration on her left thumb after a burn. Examination revealed an ulcerative tumour invading the bone with areas of haemorrhage. Microscopic examination showed an epithelioid neoplasm with central necrosis. The neoplastic cells formed dyscohesive sheets, slit-like channels, and pseudovascular spaces. Erythrocytes were frequently observed in these areas. The neoplastic malignant cells were diffusely positive for cytokeratin AE1/AE3, EMA, vimentin, Fli-1; while focally positive for CD34 and CD31. The morphology and immunophenotype overlap with a vascular neo- plasm. Additional immunohistochemical stain revealed loss of SMARCB1/INI1 expression supporting the diagnosis of epithelioid sarcoma of distal type, angiomatoid variant. We present a distinctive case of angiomatoid epithelioid sarcoma that developed in a burn ulcer and highlight pathological characteristics that distinguish it from epithelioid vascular neoplasms. Faculty of Medicine and Health Sciences, Universiti Putra Malaysia 2022-12 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/99319/1/2022121912513218_MJMHS_0388.pdf Lai, Shau Kong and Tan, Ling Tze and Tan, Lii Jye and Koh, Cai Ping and Yahaya, Balqis and Hussin, Huzlinda (2022) A case of angiomatoid epithelioid sarcoma mimicking an epithelioid vascular neoplasm. Malaysian Journal of Medicine and Health Sciences, 18 (supp.21). pp. 122-125. ISSN 2636-9346 https://medic.upm.edu.my/upload/dokumen/2022121912513218_MJMHS_0388.pdf 10.47836/mjmhs18.s21.19 |
| spellingShingle | Lai, Shau Kong Tan, Ling Tze Tan, Lii Jye Koh, Cai Ping Yahaya, Balqis Hussin, Huzlinda A case of angiomatoid epithelioid sarcoma mimicking an epithelioid vascular neoplasm |
| title | A case of angiomatoid epithelioid sarcoma mimicking an epithelioid vascular neoplasm |
| title_full | A case of angiomatoid epithelioid sarcoma mimicking an epithelioid vascular neoplasm |
| title_fullStr | A case of angiomatoid epithelioid sarcoma mimicking an epithelioid vascular neoplasm |
| title_full_unstemmed | A case of angiomatoid epithelioid sarcoma mimicking an epithelioid vascular neoplasm |
| title_short | A case of angiomatoid epithelioid sarcoma mimicking an epithelioid vascular neoplasm |
| title_sort | case of angiomatoid epithelioid sarcoma mimicking an epithelioid vascular neoplasm |
| url | http://psasir.upm.edu.my/id/eprint/99319/ http://psasir.upm.edu.my/id/eprint/99319/ http://psasir.upm.edu.my/id/eprint/99319/ http://psasir.upm.edu.my/id/eprint/99319/1/2022121912513218_MJMHS_0388.pdf |