High CD14 antigen expression in urothelial bladder carcinoma establishes that the inflammatory microenvironment promotes tumour cell proliferation
Introduction: CD-14 is an antigen found on the bladder cancer cells that mediated cancer development by providing a supportive inflammatory microenvironment. The study investigates the association of CD14 antigen expression in bladder cancer cells with demographic factors, clinicopathological parame...
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| Format: | Article |
| Language: | English |
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Faculty of Medicine and Health Sciences, Universiti Putra Malaysia
2022
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| Online Access: | http://psasir.upm.edu.my/id/eprint/99294/ http://psasir.upm.edu.my/id/eprint/99294/1/2022121911504205_MJMHS_0233.pdf |
| _version_ | 1848863093252161536 |
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| author | Ahmad, Aiful Mohd Yusoff, Suryati Mohd Ali, Razana Osman, Malina Lai, Shau Kong Hussin, Huzlinda |
| author_facet | Ahmad, Aiful Mohd Yusoff, Suryati Mohd Ali, Razana Osman, Malina Lai, Shau Kong Hussin, Huzlinda |
| author_sort | Ahmad, Aiful |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Introduction: CD-14 is an antigen found on the bladder cancer cells that mediated cancer development by providing a supportive inflammatory microenvironment. The study investigates the association of CD14 antigen expression in bladder cancer cells with demographic factors, clinicopathological parameters and recurrent cases by immuno- histochemical (IHC) method. Methods: A retrospective study using 59 formalin-fixed paraffin-embedded tissue of urothelial bladder carcinoma cases were subjected to CD14 IHC staining. Results: Most patients were 65 years old (57.6%), Malay in ethnicity (55.9%) and male predominant (94.9%). CD14 was positively expressed in more than 50% of tumour cells in all grades and stages with the largest percentage seen in the highest grade (Grade III) and stage (Stage IV) of urothelial bladder carcinoma. There was a significant association between CD14 expression and tumour grade of urothelial bladder carcinoma (p = 0.043). However, there was no significant association between CD14 expression with demographic factors, tumour stage or recurrent cases. Conclusion: High CD14 antigen expression by cancer cells establishes that the inflammatory microenvironment promotes tumour cell growth and may suggest CD14 antigen as a poor prognostic marker in urothelial bladder carcinoma. |
| first_indexed | 2025-11-15T13:27:26Z |
| format | Article |
| id | upm-99294 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T13:27:26Z |
| publishDate | 2022 |
| publisher | Faculty of Medicine and Health Sciences, Universiti Putra Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-992942023-03-06T04:08:32Z http://psasir.upm.edu.my/id/eprint/99294/ High CD14 antigen expression in urothelial bladder carcinoma establishes that the inflammatory microenvironment promotes tumour cell proliferation Ahmad, Aiful Mohd Yusoff, Suryati Mohd Ali, Razana Osman, Malina Lai, Shau Kong Hussin, Huzlinda Introduction: CD-14 is an antigen found on the bladder cancer cells that mediated cancer development by providing a supportive inflammatory microenvironment. The study investigates the association of CD14 antigen expression in bladder cancer cells with demographic factors, clinicopathological parameters and recurrent cases by immuno- histochemical (IHC) method. Methods: A retrospective study using 59 formalin-fixed paraffin-embedded tissue of urothelial bladder carcinoma cases were subjected to CD14 IHC staining. Results: Most patients were 65 years old (57.6%), Malay in ethnicity (55.9%) and male predominant (94.9%). CD14 was positively expressed in more than 50% of tumour cells in all grades and stages with the largest percentage seen in the highest grade (Grade III) and stage (Stage IV) of urothelial bladder carcinoma. There was a significant association between CD14 expression and tumour grade of urothelial bladder carcinoma (p = 0.043). However, there was no significant association between CD14 expression with demographic factors, tumour stage or recurrent cases. Conclusion: High CD14 antigen expression by cancer cells establishes that the inflammatory microenvironment promotes tumour cell growth and may suggest CD14 antigen as a poor prognostic marker in urothelial bladder carcinoma. Faculty of Medicine and Health Sciences, Universiti Putra Malaysia 2022-12 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/99294/1/2022121911504205_MJMHS_0233.pdf Ahmad, Aiful and Mohd Yusoff, Suryati and Mohd Ali, Razana and Osman, Malina and Lai, Shau Kong and Hussin, Huzlinda (2022) High CD14 antigen expression in urothelial bladder carcinoma establishes that the inflammatory microenvironment promotes tumour cell proliferation. Malaysian Journal of Medicine and Health Sciences, 18 (supp.21). pp. 30-35. ISSN 2636-9346 https://medic.upm.edu.my/upload/dokumen/2022121911504205_MJMHS_0233.pdf 10.47836/mjmhs18.s21.6 |
| spellingShingle | Ahmad, Aiful Mohd Yusoff, Suryati Mohd Ali, Razana Osman, Malina Lai, Shau Kong Hussin, Huzlinda High CD14 antigen expression in urothelial bladder carcinoma establishes that the inflammatory microenvironment promotes tumour cell proliferation |
| title | High CD14 antigen expression in urothelial bladder carcinoma establishes that the inflammatory microenvironment promotes tumour cell proliferation |
| title_full | High CD14 antigen expression in urothelial bladder carcinoma establishes that the inflammatory microenvironment promotes tumour cell proliferation |
| title_fullStr | High CD14 antigen expression in urothelial bladder carcinoma establishes that the inflammatory microenvironment promotes tumour cell proliferation |
| title_full_unstemmed | High CD14 antigen expression in urothelial bladder carcinoma establishes that the inflammatory microenvironment promotes tumour cell proliferation |
| title_short | High CD14 antigen expression in urothelial bladder carcinoma establishes that the inflammatory microenvironment promotes tumour cell proliferation |
| title_sort | high cd14 antigen expression in urothelial bladder carcinoma establishes that the inflammatory microenvironment promotes tumour cell proliferation |
| url | http://psasir.upm.edu.my/id/eprint/99294/ http://psasir.upm.edu.my/id/eprint/99294/ http://psasir.upm.edu.my/id/eprint/99294/ http://psasir.upm.edu.my/id/eprint/99294/1/2022121911504205_MJMHS_0233.pdf |