Effect of systemic administration of granulocyte-colony stimulating factor on rate of fracture healing of bone defect in goats as animal model
Granulocyte-colony stimulating factor (G-CSF) serves as an important cytokine in haematopoiesis; released at both physiological and pathological conditions by a range of cells. We hypothesized that the systemic administration of G-CSF would produce an accelerated fracture-healing rate in non-union...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Faculty of Medicine and Health Sciences, Universiti Putra Malaysia
2022
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/98691/ http://psasir.upm.edu.my/id/eprint/98691/1/2022071815383828_MJMHS_0987.pdf |
| _version_ | 1848862932565229568 |
|---|---|
| author | Looi, Collin Seng Kim Khairuddin, Nurul H. Chen, Hui Cheng Ramasamy, Rajesh Lau, Seng Fong A. Roohi, Sharifah |
| author_facet | Looi, Collin Seng Kim Khairuddin, Nurul H. Chen, Hui Cheng Ramasamy, Rajesh Lau, Seng Fong A. Roohi, Sharifah |
| author_sort | Looi, Collin Seng Kim |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Granulocyte-colony stimulating factor (G-CSF) serves as an important cytokine in haematopoiesis; released at both
physiological and pathological conditions by a range of cells. We hypothesized that the systemic administration of
G-CSF would produce an accelerated fracture-healing rate in non-union bone defects; thus, potentially leading to
useful clinical applications. Ten male adult Katjang goats, weighing about 15-26 kilograms were randomly chosen
and a tibial bone defect was induced in each animal. The defect was maintained by internal fixation with a titanium
plate and reinforced by an external fiberglass cast. Post-operative radiographs were performed twice weekly and
radiographic assessments were performed by evaluating the bridging and union measurements through a validated
method. In the treatment group, the time for bridging and union exhibited statistically significant differences when
compared with a control group. The outcomes of the present study establishing a notion that administration of G-CSF
besides inducing haematopoiesis, promotes healing of fractures and non-union bone defects as well. |
| first_indexed | 2025-11-15T13:24:53Z |
| format | Article |
| id | upm-98691 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T13:24:53Z |
| publishDate | 2022 |
| publisher | Faculty of Medicine and Health Sciences, Universiti Putra Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-986912022-11-22T07:05:15Z http://psasir.upm.edu.my/id/eprint/98691/ Effect of systemic administration of granulocyte-colony stimulating factor on rate of fracture healing of bone defect in goats as animal model Looi, Collin Seng Kim Khairuddin, Nurul H. Chen, Hui Cheng Ramasamy, Rajesh Lau, Seng Fong A. Roohi, Sharifah Granulocyte-colony stimulating factor (G-CSF) serves as an important cytokine in haematopoiesis; released at both physiological and pathological conditions by a range of cells. We hypothesized that the systemic administration of G-CSF would produce an accelerated fracture-healing rate in non-union bone defects; thus, potentially leading to useful clinical applications. Ten male adult Katjang goats, weighing about 15-26 kilograms were randomly chosen and a tibial bone defect was induced in each animal. The defect was maintained by internal fixation with a titanium plate and reinforced by an external fiberglass cast. Post-operative radiographs were performed twice weekly and radiographic assessments were performed by evaluating the bridging and union measurements through a validated method. In the treatment group, the time for bridging and union exhibited statistically significant differences when compared with a control group. The outcomes of the present study establishing a notion that administration of G-CSF besides inducing haematopoiesis, promotes healing of fractures and non-union bone defects as well. Faculty of Medicine and Health Sciences, Universiti Putra Malaysia 2022-07 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/98691/1/2022071815383828_MJMHS_0987.pdf Looi, Collin Seng Kim and Khairuddin, Nurul H. and Chen, Hui Cheng and Ramasamy, Rajesh and Lau, Seng Fong and A. Roohi, Sharifah (2022) Effect of systemic administration of granulocyte-colony stimulating factor on rate of fracture healing of bone defect in goats as animal model. Malaysian Journal of Medicine and Health Sciences, 18 (4). pp. 211-217. ISSN 2636-9346 http://psasir.upm.edu.my/id/eprint/98691/1/2022071815383828_MJMHS_0987.pdf 10.47836/mjmhs18.4.28 |
| spellingShingle | Looi, Collin Seng Kim Khairuddin, Nurul H. Chen, Hui Cheng Ramasamy, Rajesh Lau, Seng Fong A. Roohi, Sharifah Effect of systemic administration of granulocyte-colony stimulating factor on rate of fracture healing of bone defect in goats as animal model |
| title | Effect of systemic administration of granulocyte-colony stimulating factor on rate of fracture healing of bone defect in goats as animal model |
| title_full | Effect of systemic administration of granulocyte-colony stimulating factor on rate of fracture healing of bone defect in goats as animal model |
| title_fullStr | Effect of systemic administration of granulocyte-colony stimulating factor on rate of fracture healing of bone defect in goats as animal model |
| title_full_unstemmed | Effect of systemic administration of granulocyte-colony stimulating factor on rate of fracture healing of bone defect in goats as animal model |
| title_short | Effect of systemic administration of granulocyte-colony stimulating factor on rate of fracture healing of bone defect in goats as animal model |
| title_sort | effect of systemic administration of granulocyte-colony stimulating factor on rate of fracture healing of bone defect in goats as animal model |
| url | http://psasir.upm.edu.my/id/eprint/98691/ http://psasir.upm.edu.my/id/eprint/98691/ http://psasir.upm.edu.my/id/eprint/98691/ http://psasir.upm.edu.my/id/eprint/98691/1/2022071815383828_MJMHS_0987.pdf |