Effects of white rice-based carbohydrates diets on body weight and metabolic parameters in rats
Introduction: We clarified the extent to which white rice (WR)-based carbohydrate diets affect body weight and metabolic parameters in rats. Methods: In this experimental study, a male Sprague Dawley (n=32) rats fed with WRbased CHO diet in two different proportions of total energy intake (TEI 55% m...
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| Format: | Article |
| Language: | English |
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Faculty of Medicine and Health Sciences, Universiti Putra Malaysia
2022
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| Online Access: | http://psasir.upm.edu.my/id/eprint/98110/ http://psasir.upm.edu.my/id/eprint/98110/1/2022011912065031_MJMHS_1154.pdf |
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| author | Osman, Nur Maziah Hanum Mohd Yusof, Barakatun Nisak Jeevetha, Subramaniam Ismail, Amin Azlan, Azrina Goh, Yong Meng Kamaruddin, Nor Azmi Wakisaka, Minato |
| author_facet | Osman, Nur Maziah Hanum Mohd Yusof, Barakatun Nisak Jeevetha, Subramaniam Ismail, Amin Azlan, Azrina Goh, Yong Meng Kamaruddin, Nor Azmi Wakisaka, Minato |
| author_sort | Osman, Nur Maziah Hanum |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Introduction: We clarified the extent to which white rice (WR)-based carbohydrate diets affect body weight and metabolic parameters in rats. Methods: In this experimental study, a male Sprague Dawley (n=32) rats fed with WRbased CHO diet in two different proportions of total energy intake (TEI 55% moderate-CHO (MCHO, n=8) and 65% High-CHO (HCHO, n=8)) or high-fat diet (HFD, n=8) were compared with rats maintained on standard pellet diet (SD, n=8) for eight weeks period. Carbohydrate sources in the HFD and SD were mainly based on cornstarch (25% of amylose). Outcomes measures include body weight and metabolic parameters. Results: At baseline, body weight and metabolic parameters (fasting plasma glucose, insulin, and triglyceride levels) were comparable in all rats. Despite higher daily caloric intake in rats fed with HFD (103.9±3.0) than the other diets, no significant differences in body weight between groups after 8 weeks of study. However, rats’ feds with WR-based CHO diets (both moderate and high carbohydrates) had higher fasting blood glucose (MCHO=12.8±1.6, HCHO=16.9±2.4) and triglycerides level (MCHO=1.2±0.0, HCHO=1.3±0.0) than rats in cornstarch-based HFD and SD (p <0.05). Both HFD and HCHO had higher fasting insulin than MCHO and SD (p<0.05), but the homeostatic model assessment of insulin resistance (HOMA-IR) was significantly higher in WR-based CHO diets (both moderate and high carbohydrates) than the rats in cornstarch-based HFD and SD (p<0.05). Conclusion: A WR-based CHO diet exhibits higher fasting blood glucose, triglycerides, and insulin resistance state than a high-fat diet without a significant impact on body weight. These findings may explain the growing incidence of diabetes in Asia and worth studying further. |
| first_indexed | 2025-11-15T13:22:28Z |
| format | Article |
| id | upm-98110 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T13:22:28Z |
| publishDate | 2022 |
| publisher | Faculty of Medicine and Health Sciences, Universiti Putra Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-981102022-08-11T03:44:52Z http://psasir.upm.edu.my/id/eprint/98110/ Effects of white rice-based carbohydrates diets on body weight and metabolic parameters in rats Osman, Nur Maziah Hanum Mohd Yusof, Barakatun Nisak Jeevetha, Subramaniam Ismail, Amin Azlan, Azrina Goh, Yong Meng Kamaruddin, Nor Azmi Wakisaka, Minato Introduction: We clarified the extent to which white rice (WR)-based carbohydrate diets affect body weight and metabolic parameters in rats. Methods: In this experimental study, a male Sprague Dawley (n=32) rats fed with WRbased CHO diet in two different proportions of total energy intake (TEI 55% moderate-CHO (MCHO, n=8) and 65% High-CHO (HCHO, n=8)) or high-fat diet (HFD, n=8) were compared with rats maintained on standard pellet diet (SD, n=8) for eight weeks period. Carbohydrate sources in the HFD and SD were mainly based on cornstarch (25% of amylose). Outcomes measures include body weight and metabolic parameters. Results: At baseline, body weight and metabolic parameters (fasting plasma glucose, insulin, and triglyceride levels) were comparable in all rats. Despite higher daily caloric intake in rats fed with HFD (103.9±3.0) than the other diets, no significant differences in body weight between groups after 8 weeks of study. However, rats’ feds with WR-based CHO diets (both moderate and high carbohydrates) had higher fasting blood glucose (MCHO=12.8±1.6, HCHO=16.9±2.4) and triglycerides level (MCHO=1.2±0.0, HCHO=1.3±0.0) than rats in cornstarch-based HFD and SD (p <0.05). Both HFD and HCHO had higher fasting insulin than MCHO and SD (p<0.05), but the homeostatic model assessment of insulin resistance (HOMA-IR) was significantly higher in WR-based CHO diets (both moderate and high carbohydrates) than the rats in cornstarch-based HFD and SD (p<0.05). Conclusion: A WR-based CHO diet exhibits higher fasting blood glucose, triglycerides, and insulin resistance state than a high-fat diet without a significant impact on body weight. These findings may explain the growing incidence of diabetes in Asia and worth studying further. Faculty of Medicine and Health Sciences, Universiti Putra Malaysia 2022-01 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/98110/1/2022011912065031_MJMHS_1154.pdf Osman, Nur Maziah Hanum and Mohd Yusof, Barakatun Nisak and Jeevetha, Subramaniam and Ismail, Amin and Azlan, Azrina and Goh, Yong Meng and Kamaruddin, Nor Azmi and Wakisaka, Minato (2022) Effects of white rice-based carbohydrates diets on body weight and metabolic parameters in rats. Malaysian Journal of Medicine and Health Sciences, 18 (1). pp. 234-240. ISSN 2636-9346 https://medic.upm.edu.my/upload/dokumen/2022011912065031_MJMHS_1154.pdf |
| spellingShingle | Osman, Nur Maziah Hanum Mohd Yusof, Barakatun Nisak Jeevetha, Subramaniam Ismail, Amin Azlan, Azrina Goh, Yong Meng Kamaruddin, Nor Azmi Wakisaka, Minato Effects of white rice-based carbohydrates diets on body weight and metabolic parameters in rats |
| title | Effects of white rice-based carbohydrates diets on body weight and metabolic parameters in rats |
| title_full | Effects of white rice-based carbohydrates diets on body weight and metabolic parameters in rats |
| title_fullStr | Effects of white rice-based carbohydrates diets on body weight and metabolic parameters in rats |
| title_full_unstemmed | Effects of white rice-based carbohydrates diets on body weight and metabolic parameters in rats |
| title_short | Effects of white rice-based carbohydrates diets on body weight and metabolic parameters in rats |
| title_sort | effects of white rice-based carbohydrates diets on body weight and metabolic parameters in rats |
| url | http://psasir.upm.edu.my/id/eprint/98110/ http://psasir.upm.edu.my/id/eprint/98110/ http://psasir.upm.edu.my/id/eprint/98110/1/2022011912065031_MJMHS_1154.pdf |