Hybrid nerve sheath tumour, a conglomerate of separate entities
Hybrid nerve sheath tumours (HNSTs) are benign tumours showing combined features of more than one peripheral nerve sheath tumour (PNST) entities. Most literature highlight combination of two entities. Only few reported cases involve all three components of PNST. Herein, we report a case of 33-year-o...
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| Format: | Article |
| Language: | English |
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Universiti Putra Malaysia
2021
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| Online Access: | http://psasir.upm.edu.my/id/eprint/97577/ http://psasir.upm.edu.my/id/eprint/97577/1/2021120708275619_MJMHS_0768.pdf |
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| author | Omar, Noorjehan Mohd Dusa, Noraini Bakhrin, Ikmal Hisyam Omar, Noor Azzizah Vasavan, Yabitha |
| author_facet | Omar, Noorjehan Mohd Dusa, Noraini Bakhrin, Ikmal Hisyam Omar, Noor Azzizah Vasavan, Yabitha |
| author_sort | Omar, Noorjehan |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Hybrid nerve sheath tumours (HNSTs) are benign tumours showing combined features of more than one peripheral nerve sheath tumour (PNST) entities. Most literature highlight combination of two entities. Only few reported cases involve all three components of PNST. Herein, we report a case of 33-year-old Malay lady, with left proximal middle finger soft tissue swelling for three months. Microscopically, the tumour is well-circumscribed, containing all three components of PNST, with each displaying its typical morphology and immunohistochemical staining pattern. This case suggests that PNSTs may be more closely related than what was earlier believed. However, whether HNSTs are part of the PNSTs spectrum with tumour syndromes association or a distinct entity is still a continuous debate. We also highlight the possibilities of recurrence and risk of malignant transformation in HNSTs. The exact pathogenesis,
potential for recurrence and malignant transformation criteria for HNSTs are still vague due to their extreme rarity. |
| first_indexed | 2025-11-15T13:20:12Z |
| format | Article |
| id | upm-97577 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T13:20:12Z |
| publishDate | 2021 |
| publisher | Universiti Putra Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-975772022-07-27T01:47:34Z http://psasir.upm.edu.my/id/eprint/97577/ Hybrid nerve sheath tumour, a conglomerate of separate entities Omar, Noorjehan Mohd Dusa, Noraini Bakhrin, Ikmal Hisyam Omar, Noor Azzizah Vasavan, Yabitha Hybrid nerve sheath tumours (HNSTs) are benign tumours showing combined features of more than one peripheral nerve sheath tumour (PNST) entities. Most literature highlight combination of two entities. Only few reported cases involve all three components of PNST. Herein, we report a case of 33-year-old Malay lady, with left proximal middle finger soft tissue swelling for three months. Microscopically, the tumour is well-circumscribed, containing all three components of PNST, with each displaying its typical morphology and immunohistochemical staining pattern. This case suggests that PNSTs may be more closely related than what was earlier believed. However, whether HNSTs are part of the PNSTs spectrum with tumour syndromes association or a distinct entity is still a continuous debate. We also highlight the possibilities of recurrence and risk of malignant transformation in HNSTs. The exact pathogenesis, potential for recurrence and malignant transformation criteria for HNSTs are still vague due to their extreme rarity. Universiti Putra Malaysia 2021 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/97577/1/2021120708275619_MJMHS_0768.pdf Omar, Noorjehan and Mohd Dusa, Noraini and Bakhrin, Ikmal Hisyam and Omar, Noor Azzizah and Vasavan, Yabitha (2021) Hybrid nerve sheath tumour, a conglomerate of separate entities. Malaysian Journal of Medicine and Health Sciences, 17 (suppl.10). 111 - 114. ISSN 2636-9346 https://medic.upm.edu.my/upload/dokumen/2021120708275619_MJMHS_0768.pdf |
| spellingShingle | Omar, Noorjehan Mohd Dusa, Noraini Bakhrin, Ikmal Hisyam Omar, Noor Azzizah Vasavan, Yabitha Hybrid nerve sheath tumour, a conglomerate of separate entities |
| title | Hybrid nerve sheath tumour, a conglomerate of separate entities |
| title_full | Hybrid nerve sheath tumour, a conglomerate of separate entities |
| title_fullStr | Hybrid nerve sheath tumour, a conglomerate of separate entities |
| title_full_unstemmed | Hybrid nerve sheath tumour, a conglomerate of separate entities |
| title_short | Hybrid nerve sheath tumour, a conglomerate of separate entities |
| title_sort | hybrid nerve sheath tumour, a conglomerate of separate entities |
| url | http://psasir.upm.edu.my/id/eprint/97577/ http://psasir.upm.edu.my/id/eprint/97577/ http://psasir.upm.edu.my/id/eprint/97577/1/2021120708275619_MJMHS_0768.pdf |