Exercise-induced ruptured renal tumour in a young patient with hereditary leiomyomata-associated renal cell carcinoma (HLRCC): a case report
Background: Hereditary leiomyomatosis-associated renal cell carcinoma (HLRCC) is rare with only 300 families reported to date worldwide. Despite highlighting renal malignancy, it is infamous for its cutaneous and leiomyomatosis component as the more common cause of presentation. This report is to hi...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Springer
2021
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| Online Access: | http://psasir.upm.edu.my/id/eprint/97192/ http://psasir.upm.edu.my/id/eprint/97192/1/ABSTRACT.pdf |
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| author | Mohamad Sharin, Mohamad Fairuz Pushpanathan, Mugialan Jagwani, Arvind Vashdev Mohd Ghani, Khairul Asri Mohd Zainuddin, Saiful Azli Omar, Noorjehan Mohd Firdaus, Mohd Hayati |
| author_facet | Mohamad Sharin, Mohamad Fairuz Pushpanathan, Mugialan Jagwani, Arvind Vashdev Mohd Ghani, Khairul Asri Mohd Zainuddin, Saiful Azli Omar, Noorjehan Mohd Firdaus, Mohd Hayati |
| author_sort | Mohamad Sharin, Mohamad Fairuz |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Background: Hereditary leiomyomatosis-associated renal cell carcinoma (HLRCC) is rare with only 300 families reported to date worldwide. Despite highlighting renal malignancy, it is infamous for its cutaneous and leiomyomatosis component as the more common cause of presentation. This report is to highlight the rare presentation of HLRCC which occurs in a teenager which is unfortunately complicated with exercise-induced renal tumour rupture. Case presentation: A 22-year-old gentleman presented with severe right lower abdominal pain for 4 days, associated with fever and nausea following a session of strenuous exercise. He has frst-degree relatives and second-degree relatives from his maternal side who were genetically tested positive for HLRCC. Clinical examination revealed a tender right lumbar and right iliac fossa region. A computed tomography of the kidneys demonstrated a ruptured right renal tumour with a large right renal subcapsular and contained right retroperitoneal hematoma. An emergency right radical nephrectomy was performed, and he recovered well. The histopathological examination was consistent with HLRCC associated ruptured right renal cell carcinoma. Conclusion: Identifcation of this underreported familial malignancy is paramount as the onset of neoplasia occurs much earlier in life. This necessitates screening of family members at a younger age, and the management is followed by life-long surveillance. |
| first_indexed | 2025-11-15T13:18:36Z |
| format | Article |
| id | upm-97192 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T13:18:36Z |
| publishDate | 2021 |
| publisher | Springer |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-971922022-09-13T08:28:05Z http://psasir.upm.edu.my/id/eprint/97192/ Exercise-induced ruptured renal tumour in a young patient with hereditary leiomyomata-associated renal cell carcinoma (HLRCC): a case report Mohamad Sharin, Mohamad Fairuz Pushpanathan, Mugialan Jagwani, Arvind Vashdev Mohd Ghani, Khairul Asri Mohd Zainuddin, Saiful Azli Omar, Noorjehan Mohd Firdaus, Mohd Hayati Background: Hereditary leiomyomatosis-associated renal cell carcinoma (HLRCC) is rare with only 300 families reported to date worldwide. Despite highlighting renal malignancy, it is infamous for its cutaneous and leiomyomatosis component as the more common cause of presentation. This report is to highlight the rare presentation of HLRCC which occurs in a teenager which is unfortunately complicated with exercise-induced renal tumour rupture. Case presentation: A 22-year-old gentleman presented with severe right lower abdominal pain for 4 days, associated with fever and nausea following a session of strenuous exercise. He has frst-degree relatives and second-degree relatives from his maternal side who were genetically tested positive for HLRCC. Clinical examination revealed a tender right lumbar and right iliac fossa region. A computed tomography of the kidneys demonstrated a ruptured right renal tumour with a large right renal subcapsular and contained right retroperitoneal hematoma. An emergency right radical nephrectomy was performed, and he recovered well. The histopathological examination was consistent with HLRCC associated ruptured right renal cell carcinoma. Conclusion: Identifcation of this underreported familial malignancy is paramount as the onset of neoplasia occurs much earlier in life. This necessitates screening of family members at a younger age, and the management is followed by life-long surveillance. Springer 2021 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/97192/1/ABSTRACT.pdf Mohamad Sharin, Mohamad Fairuz and Pushpanathan, Mugialan and Jagwani, Arvind Vashdev and Mohd Ghani, Khairul Asri and Mohd Zainuddin, Saiful Azli and Omar, Noorjehan and Mohd Firdaus, Mohd Hayati (2021) Exercise-induced ruptured renal tumour in a young patient with hereditary leiomyomata-associated renal cell carcinoma (HLRCC): a case report. African Journal of Urology, 27. art. no. 159. pp. 1-4. ISSN 1110-5704 https://afju.springeropen.com/articles/10.1186/s12301-021-00263-6 10.1186/s12301-021-00263-6 |
| spellingShingle | Mohamad Sharin, Mohamad Fairuz Pushpanathan, Mugialan Jagwani, Arvind Vashdev Mohd Ghani, Khairul Asri Mohd Zainuddin, Saiful Azli Omar, Noorjehan Mohd Firdaus, Mohd Hayati Exercise-induced ruptured renal tumour in a young patient with hereditary leiomyomata-associated renal cell carcinoma (HLRCC): a case report |
| title | Exercise-induced ruptured renal tumour in a young patient with hereditary leiomyomata-associated renal cell carcinoma (HLRCC): a case report |
| title_full | Exercise-induced ruptured renal tumour in a young patient with hereditary leiomyomata-associated renal cell carcinoma (HLRCC): a case report |
| title_fullStr | Exercise-induced ruptured renal tumour in a young patient with hereditary leiomyomata-associated renal cell carcinoma (HLRCC): a case report |
| title_full_unstemmed | Exercise-induced ruptured renal tumour in a young patient with hereditary leiomyomata-associated renal cell carcinoma (HLRCC): a case report |
| title_short | Exercise-induced ruptured renal tumour in a young patient with hereditary leiomyomata-associated renal cell carcinoma (HLRCC): a case report |
| title_sort | exercise-induced ruptured renal tumour in a young patient with hereditary leiomyomata-associated renal cell carcinoma (hlrcc): a case report |
| url | http://psasir.upm.edu.my/id/eprint/97192/ http://psasir.upm.edu.my/id/eprint/97192/ http://psasir.upm.edu.my/id/eprint/97192/ http://psasir.upm.edu.my/id/eprint/97192/1/ABSTRACT.pdf |