Electrochemical detection of a local anesthetic dibucaine at arrays of micro liquid liquid interfaces
Electrochemical characterization and detection of protonated dibucaine (DIC+) at microinterface array across water|1,6-dichlorohexane were performed using cyclic voltammetry (CV) and differential pulse voltammetry (DPV). Some thermodynamic parameters of dibucaine, such as the standard transfer poten...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Multidisciplinary Digital Publishing Institute
2021
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| Online Access: | http://psasir.upm.edu.my/id/eprint/97051/ http://psasir.upm.edu.my/id/eprint/97051/1/ABSTRACT.pdf |
| _version_ | 1848862504556429312 |
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| author | Almbrok Abdulla, Eissa Mohamed Yusof, Nor Azah Abdullah, Jaafar Mohd Zawawi, Ruzniza |
| author_facet | Almbrok Abdulla, Eissa Mohamed Yusof, Nor Azah Abdullah, Jaafar Mohd Zawawi, Ruzniza |
| author_sort | Almbrok Abdulla, Eissa Mohamed |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Electrochemical characterization and detection of protonated dibucaine (DIC+) at microinterface array across water|1,6-dichlorohexane were performed using cyclic voltammetry (CV) and differential pulse voltammetry (DPV). Some thermodynamic parameters of dibucaine, such as the standard transfer potential, the Gibbs energy of transfer and the partition coefficient, were estimated by CV. In addition to the analytical parameters, the impact of bovine serum albumin (BSA) on dibucaine detection (in artificial serum matrices) was also investigated. DPV was applied to detect a lower concentration of DIC+, resulting in a detection limit of 0.9 ± 0.06 µM. While the presence of BSA affected CV, demonstrated as reduced current responses, DPV was confirmed to be an efficient method for lowering concentrations of the dibucaine detection in the artificial serum matrix in the presence of BSA, with a limit of detection (LOD) of 1.9 ± 0.12 µM. |
| first_indexed | 2025-11-15T13:18:05Z |
| format | Article |
| id | upm-97051 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T13:18:05Z |
| publishDate | 2021 |
| publisher | Multidisciplinary Digital Publishing Institute |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-970512022-10-17T01:12:46Z http://psasir.upm.edu.my/id/eprint/97051/ Electrochemical detection of a local anesthetic dibucaine at arrays of micro liquid liquid interfaces Almbrok Abdulla, Eissa Mohamed Yusof, Nor Azah Abdullah, Jaafar Mohd Zawawi, Ruzniza Electrochemical characterization and detection of protonated dibucaine (DIC+) at microinterface array across water|1,6-dichlorohexane were performed using cyclic voltammetry (CV) and differential pulse voltammetry (DPV). Some thermodynamic parameters of dibucaine, such as the standard transfer potential, the Gibbs energy of transfer and the partition coefficient, were estimated by CV. In addition to the analytical parameters, the impact of bovine serum albumin (BSA) on dibucaine detection (in artificial serum matrices) was also investigated. DPV was applied to detect a lower concentration of DIC+, resulting in a detection limit of 0.9 ± 0.06 µM. While the presence of BSA affected CV, demonstrated as reduced current responses, DPV was confirmed to be an efficient method for lowering concentrations of the dibucaine detection in the artificial serum matrix in the presence of BSA, with a limit of detection (LOD) of 1.9 ± 0.12 µM. Multidisciplinary Digital Publishing Institute 2021 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/97051/1/ABSTRACT.pdf Almbrok Abdulla, Eissa Mohamed and Yusof, Nor Azah and Abdullah, Jaafar and Mohd Zawawi, Ruzniza (2021) Electrochemical detection of a local anesthetic dibucaine at arrays of micro liquid liquid interfaces. Chemosensors, 9 (1). pp. 1-15. ISSN 2227-9040 https://www.mdpi.com/2227-9040/9/1/15 10.3390/chemosensors9010015 |
| spellingShingle | Almbrok Abdulla, Eissa Mohamed Yusof, Nor Azah Abdullah, Jaafar Mohd Zawawi, Ruzniza Electrochemical detection of a local anesthetic dibucaine at arrays of micro liquid liquid interfaces |
| title | Electrochemical detection of a local anesthetic dibucaine at arrays of micro liquid liquid interfaces |
| title_full | Electrochemical detection of a local anesthetic dibucaine at arrays of micro liquid liquid interfaces |
| title_fullStr | Electrochemical detection of a local anesthetic dibucaine at arrays of micro liquid liquid interfaces |
| title_full_unstemmed | Electrochemical detection of a local anesthetic dibucaine at arrays of micro liquid liquid interfaces |
| title_short | Electrochemical detection of a local anesthetic dibucaine at arrays of micro liquid liquid interfaces |
| title_sort | electrochemical detection of a local anesthetic dibucaine at arrays of micro liquid liquid interfaces |
| url | http://psasir.upm.edu.my/id/eprint/97051/ http://psasir.upm.edu.my/id/eprint/97051/ http://psasir.upm.edu.my/id/eprint/97051/ http://psasir.upm.edu.my/id/eprint/97051/1/ABSTRACT.pdf |