Electrochemical and thermodynamic properties of diclofenac and dibucaine ions across water|1,6-dichlorohexane interface
In this work, the electrochemical behaviour of diclofenac anion and dibucaine cation via a water|1,6- dichlorohexane liquid | liquid interface system was characterised. Both ions have been undergone voltammetry of ion transfer across the liquid-liquid interface. Analytical parameters such as the fo...
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| Format: | Article |
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Electrochemical Science Group
2021
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| Online Access: | http://psasir.upm.edu.my/id/eprint/97050/ |
| _version_ | 1848862504257585152 |
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| author | Almbrok Abdulla, Eissa Mohamed Yusof, Nor Azah Abdullah, Jaafar Mohd Zawawi, Ruzniza |
| author_facet | Almbrok Abdulla, Eissa Mohamed Yusof, Nor Azah Abdullah, Jaafar Mohd Zawawi, Ruzniza |
| author_sort | Almbrok Abdulla, Eissa Mohamed |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | In this work, the electrochemical behaviour of diclofenac anion and dibucaine cation via a water|1,6- dichlorohexane liquid | liquid interface system was characterised. Both ions have been undergone
voltammetry of ion transfer across the liquid-liquid interface. Analytical parameters such as the formal transfer potential, standard Gibbs energy of transfer across the interface, and the partition coefficient for both drugs were determined. The partition coefficient is of great importance for the estimation of the
lipophilicity' ions, which plays a role in its distribution in living organisms and its effect on biological media. Furthermore, the different performance characteristics of the cyclic voltammetry (CV) technique were exploited to extract the values of the aqueous diffusion coefficients of both diclofenac and dibucaine, which were in a good agreement with the theoretically predicted values based on their molar mass, 4.18 ± 0.05 × 10−6cm2 s−1 and 3.43 ± 0.04 × 10−6
cm2s−1, respectively. |
| first_indexed | 2025-11-15T13:18:04Z |
| format | Article |
| id | upm-97050 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-15T13:18:04Z |
| publishDate | 2021 |
| publisher | Electrochemical Science Group |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-970502023-04-19T04:06:20Z http://psasir.upm.edu.my/id/eprint/97050/ Electrochemical and thermodynamic properties of diclofenac and dibucaine ions across water|1,6-dichlorohexane interface Almbrok Abdulla, Eissa Mohamed Yusof, Nor Azah Abdullah, Jaafar Mohd Zawawi, Ruzniza In this work, the electrochemical behaviour of diclofenac anion and dibucaine cation via a water|1,6- dichlorohexane liquid | liquid interface system was characterised. Both ions have been undergone voltammetry of ion transfer across the liquid-liquid interface. Analytical parameters such as the formal transfer potential, standard Gibbs energy of transfer across the interface, and the partition coefficient for both drugs were determined. The partition coefficient is of great importance for the estimation of the lipophilicity' ions, which plays a role in its distribution in living organisms and its effect on biological media. Furthermore, the different performance characteristics of the cyclic voltammetry (CV) technique were exploited to extract the values of the aqueous diffusion coefficients of both diclofenac and dibucaine, which were in a good agreement with the theoretically predicted values based on their molar mass, 4.18 ± 0.05 × 10−6cm2 s−1 and 3.43 ± 0.04 × 10−6 cm2s−1, respectively. Electrochemical Science Group 2021 Article PeerReviewed Almbrok Abdulla, Eissa Mohamed and Yusof, Nor Azah and Abdullah, Jaafar and Mohd Zawawi, Ruzniza (2021) Electrochemical and thermodynamic properties of diclofenac and dibucaine ions across water|1,6-dichlorohexane interface. International Journal of Electrochemical Science, 16. pp. 1-14. ISSN 1452-3981 http://www.electrochemsci.org/ 10.20964/2021.02.26 |
| spellingShingle | Almbrok Abdulla, Eissa Mohamed Yusof, Nor Azah Abdullah, Jaafar Mohd Zawawi, Ruzniza Electrochemical and thermodynamic properties of diclofenac and dibucaine ions across water|1,6-dichlorohexane interface |
| title | Electrochemical and thermodynamic properties of diclofenac
and dibucaine ions across water|1,6-dichlorohexane interface |
| title_full | Electrochemical and thermodynamic properties of diclofenac
and dibucaine ions across water|1,6-dichlorohexane interface |
| title_fullStr | Electrochemical and thermodynamic properties of diclofenac
and dibucaine ions across water|1,6-dichlorohexane interface |
| title_full_unstemmed | Electrochemical and thermodynamic properties of diclofenac
and dibucaine ions across water|1,6-dichlorohexane interface |
| title_short | Electrochemical and thermodynamic properties of diclofenac
and dibucaine ions across water|1,6-dichlorohexane interface |
| title_sort | electrochemical and thermodynamic properties of diclofenac
and dibucaine ions across water|1,6-dichlorohexane interface |
| url | http://psasir.upm.edu.my/id/eprint/97050/ http://psasir.upm.edu.my/id/eprint/97050/ http://psasir.upm.edu.my/id/eprint/97050/ |