Efficacy of live attenuated fowl adenovirus serotype 8B isolate of Malaysia in spesific pathogen-free chickens
Fowl adenovirus (FAdV) is the primary agent of inclusion body hepatitis (IBH) in poultry and caused serious economic impact due to high mortality and poor productivity. To date, clinical cases of IBH in chickens increases over the years in Malaysia, thus, an effective local vaccine to control the di...
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| Format: | Article |
| Language: | English |
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Malaysian Society of Applied Biology
2021
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| Online Access: | http://psasir.upm.edu.my/id/eprint/97028/ http://psasir.upm.edu.my/id/eprint/97028/1/Efficacy%20of%20live%20attenuated%20fowl%20adenovirus%20.pdf |
| _version_ | 1848862498898313216 |
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| author | Mohamed Sohaimi, Norfitriah Bejo, Mohd Hair |
| author_facet | Mohamed Sohaimi, Norfitriah Bejo, Mohd Hair |
| author_sort | Mohamed Sohaimi, Norfitriah |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Fowl adenovirus (FAdV) is the primary agent of inclusion body hepatitis (IBH) in poultry and caused serious economic impact due to high mortality and poor productivity. To date, clinical cases of IBH in chickens increases over the years in Malaysia, thus, an effective local vaccine to control the disease outbreak is in dire need. The objective of the study was to determine the efficacy of live attenuated FAdV serotype 8b isolate, UPM1137CEL35, in specific-pathogen-free chickens. Attenuated isolate UPM1137CEL35 conferred full protection against the virulent FAdV isolate, UPM11134 in the vaccinated chickens. Neither clinical signs nor mortality were recorded in all vaccinated groups. However, in the challenged unvaccinated group, chickens showed clinical signs of weakness, reduced feed consumption, and lateral recumbency at day 4 to 7 postchallenge. Additionally, the body weight was low significantly (p<0.05) compared to the challenged vaccinated groups. Upon necropsy, the liver from the challenged unvaccinated group was pale at peripheral bilateral lobes with the presence of focal lymphoid aggregation microscopically, while, challenged vaccinated groups were normal without significant changes. All vaccinated chickens were protected from disease manifestations with antibody response compared to the challenged unvaccinated group. It was concluded that the attenuated FAdV isolate, UPM1137CEL35, has a high potential to be used as a vaccine against the FAdV serotype 8b of Malaysian isolates. |
| first_indexed | 2025-11-15T13:17:59Z |
| format | Article |
| id | upm-97028 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T13:17:59Z |
| publishDate | 2021 |
| publisher | Malaysian Society of Applied Biology |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-970282022-10-18T01:46:59Z http://psasir.upm.edu.my/id/eprint/97028/ Efficacy of live attenuated fowl adenovirus serotype 8B isolate of Malaysia in spesific pathogen-free chickens Mohamed Sohaimi, Norfitriah Bejo, Mohd Hair Fowl adenovirus (FAdV) is the primary agent of inclusion body hepatitis (IBH) in poultry and caused serious economic impact due to high mortality and poor productivity. To date, clinical cases of IBH in chickens increases over the years in Malaysia, thus, an effective local vaccine to control the disease outbreak is in dire need. The objective of the study was to determine the efficacy of live attenuated FAdV serotype 8b isolate, UPM1137CEL35, in specific-pathogen-free chickens. Attenuated isolate UPM1137CEL35 conferred full protection against the virulent FAdV isolate, UPM11134 in the vaccinated chickens. Neither clinical signs nor mortality were recorded in all vaccinated groups. However, in the challenged unvaccinated group, chickens showed clinical signs of weakness, reduced feed consumption, and lateral recumbency at day 4 to 7 postchallenge. Additionally, the body weight was low significantly (p<0.05) compared to the challenged vaccinated groups. Upon necropsy, the liver from the challenged unvaccinated group was pale at peripheral bilateral lobes with the presence of focal lymphoid aggregation microscopically, while, challenged vaccinated groups were normal without significant changes. All vaccinated chickens were protected from disease manifestations with antibody response compared to the challenged unvaccinated group. It was concluded that the attenuated FAdV isolate, UPM1137CEL35, has a high potential to be used as a vaccine against the FAdV serotype 8b of Malaysian isolates. Malaysian Society of Applied Biology 2021 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/97028/1/Efficacy%20of%20live%20attenuated%20fowl%20adenovirus%20.pdf Mohamed Sohaimi, Norfitriah and Bejo, Mohd Hair (2021) Efficacy of live attenuated fowl adenovirus serotype 8B isolate of Malaysia in spesific pathogen-free chickens. Malaysian Applied Biology, 50 (3). pp. 1-17. ISSN 0126-8643; ESSN: 2462-151X https://www.jms.mabjournal.com/index.php/mab/article/view/1998 10.55230/mabjournal.v50i3.1998 |
| spellingShingle | Mohamed Sohaimi, Norfitriah Bejo, Mohd Hair Efficacy of live attenuated fowl adenovirus serotype 8B isolate of Malaysia in spesific pathogen-free chickens |
| title | Efficacy of live attenuated fowl adenovirus serotype 8B isolate of Malaysia in spesific pathogen-free chickens |
| title_full | Efficacy of live attenuated fowl adenovirus serotype 8B isolate of Malaysia in spesific pathogen-free chickens |
| title_fullStr | Efficacy of live attenuated fowl adenovirus serotype 8B isolate of Malaysia in spesific pathogen-free chickens |
| title_full_unstemmed | Efficacy of live attenuated fowl adenovirus serotype 8B isolate of Malaysia in spesific pathogen-free chickens |
| title_short | Efficacy of live attenuated fowl adenovirus serotype 8B isolate of Malaysia in spesific pathogen-free chickens |
| title_sort | efficacy of live attenuated fowl adenovirus serotype 8b isolate of malaysia in spesific pathogen-free chickens |
| url | http://psasir.upm.edu.my/id/eprint/97028/ http://psasir.upm.edu.my/id/eprint/97028/ http://psasir.upm.edu.my/id/eprint/97028/ http://psasir.upm.edu.my/id/eprint/97028/1/Efficacy%20of%20live%20attenuated%20fowl%20adenovirus%20.pdf |