Development of a single-chain fragment variable fused-mutant HALT-1 recombinant immunotoxin against G12V mutated KRAS colorectal cancer cells

QR Code

Development of a single-chain fragment variable fused-mutant HALT-1 recombinant immunotoxin against G12V mutated KRAS colorectal cancer cells

Background: KRAS oncogenes harboring codon G12 and G13 substitutions are considered gatekeeper mutations which drive oncogenesis in many cancers. To date, there are still no target-specific vaccines or drugs available against this genotype, thus reinforcing the need towards the development of target...

Full description

Bibliographic Details
Main Authors:	Teo, Michelle Yee Mun, Ng, Jeremy Jeack Ceen, Jung, Yin Fong, Jung, Shan Hwang, Song, Adelene Ai Lian, Lim, Renee Lay Hong, In, Lionel Lian Aun
Format:	Article
Language:	English
Published:	PeerJ Publishing 2021
Online Access:	http://psasir.upm.edu.my/id/eprint/96690/ http://psasir.upm.edu.my/id/eprint/96690/1/ABSTRACT.pdf

Similar Items

Effect of secretion efficiency of mutant KRAS neoantigen by Lactococcus lactis on the immune response of a mucosal vaccine delivery vehicle targeting colorectal cancer
by: Alias, Nur Aqlili Riana, et al.
Published: (2023)

Identification of a target protein of Hydra actinoporin-like toxin-1 (HALT-1)using GST affinity purification and SILAC-based quantitative proteomics
by: Ameirika, ., et al.
Published: (2017)

In silico-guided sequence modifications of K-ras epitopes improve immunological outcome against G12V and G13D mutant KRAS antigens
by: Wee, Allan Ren Ng, et al.
Published: (2018)

Association between autophagy and KRAS mutation with clinicopathological variables in colorectal cancer patients
by: Awi, Noel Jacques, et al.
Published: (2021)

The efficiency of trading halts: emerging market evidence
by: Bacha, Obiyathulla Ismath, et al.
Published: (2008)

K-ras peptide mimotope induces antigen specific Th1 and B-cell immune responses against G12A-mutated K-Ras antigen in balb/c mice
by: Siak, Pui Yan, et al.
Published: (2021)

Synthetic Lethality of a Novel Small Molecule Against Mutant KRAS-Expressing Cancer Cells Involves AKT-Dependent ROS Production
by: Iskandar, K., et al.
Published: (2016)

More than just a KRAS inhibitor: DCAI abrogates the self-renewal of pancreatic cancer stem cells in vitro
by: Yuan, Han Teh, et al.
Published: (2023)

Emerging role of the KRAS-PDK1 axis in pancreatic cancer
by: Ferro, R., et al.
Published: (2014)

Lactococcus lactis harbouring Ara h 2.02 alleviates allergen-specific Th2-associated responses in sensitized mice
by: Chan, Chong Joo, et al.
Published: (2020)

Response of cellular innate immunity to Cnidarian Pore-Forming toxins
by: Yap, Wei Yuen *, et al.
Published: (2018)

Chemical mutation method for high CO2- requiring- mutants of the Cyanobacterium Synechococcus sp. PCC 7002
by: Halmi Shari, Ummi Syuhada, et al.
Published: (2018)

Kepimpinan masyarakat Melayu yang berpendapatan rendah di Pantai Halt, Wilayah Persekutuan / Hamdan Hj Nordin
by: Hamdan, Hj Nordin
Published: (1978)

Melambatkan pembekuan darah ikan: UPM cipta kit ThromboHALT anticoagulant untuk mudahkan sampel diambil
by: Md Sani, Mohd Sabran
Published: (2015)

Production and characterization of human soluble CD83 fused with the fragment crystallizable region of human IgG1 in Pichia pastoris
by: Yuan, Y., et al.
Published: (2013)

Engineering Lactococcus lactis as a cell factory for the production of limonene
by: Nurul ‘Aishah Shaili,, et al.
Published: (2022)

Engineering Lactococcus lactis as a cell factory for the production of limonene
by: Shaili, Nurul ‘Aishah, et al.
Published: (2022)

Immunogenicity of a truncated enterovirus 71 VP1 protein fused to a Newcastle disease virus nucleocapsid protein fragment in mice.
by: Ch'ng, Wei Choong, et al.
Published: (2011)

Delaying emergence of resistance to KRAS inhibitors with adaptive therapy: “treatment-to-contain” instead of “treatment-to-cure”
by: Hamdi, Amir Imran Faisal, et al.
Published: (2022)

Development of clove extract-fortified functional yoghurt powder using spray: drying
by: Abdul Kalam Saleena, Lejaniya, et al.
Published: (2024)

Development of clove extract‑fortifed functional yoghurt powder using spray: drying
by: Abdul Kalam Saleena, Lejaniya, et al.
Published: (2024)

Orally dissolving yoghurt strip: a new approach in delivery of probiotics
by: Saleena, Lejaniya Abdul Kalam, et al.
Published: (2024)

Optimization of signal peptide via site-directed mutagenesis for enhanced secretion of heterologous proteins in lactococcus lactis
by: Alias, Nur Aqlili Riana, et al.
Published: (2022)

Recovery of recombinant Mycobacterium tuberculosis antigens fused with cell wall anchoring motif (LysM) from inclusion bodies using non-denaturing reagent (N-lauryl sarcosine)
by: Mustafa, Anhar Danial, et al.
Published: (2019)

FRGS final report: regulating a mis-regulation of trading halts through a comprehensive financial legal framework for the protection of investors’ interest
by: Mohamad, Azhar
Published: (2019)

Cytotoxicity of SRJ23 and its derivatives, expression and SRJ23 binding of KRas G12V oncoprotein
by: Tan, Michelle Siying
Published: (2017)

Functional expression of plant sesquitepene synthases for isoprenoid production in lactococcus lactis
by: Song, Adelene Ai Lian
Published: (2012)

Mutation analysis of apyrase gene of Shigella Flexneri- towards the development of vaccine strain
by: Aun, Seah Chin
Published: (2005)

Mutation analysis of apyrase gene of shigella jlexneri - towards the development of vaccine strain
by: Aun, Seah Chin
Published: (2005)

Fusing learning animal science with technology
by: Saad, Wan Zuhainis
Published: (2016)

Synthesis of conjugated linoleic acid-rich triacylglycerols by immobilized mutant lipase with excellent capability and recyclability
by: Lian, Weishuai, et al.
Published: (2018)

Fragments of Gravity
by: Huitson, Nicole
Published: (2013)

Space fragmentation
by: Mohd Yunos, Mohd Yazid, et al.
Published: (2010)

Stomach-specific activation of oncogenic KRAS and STAT3-dependent inflammation cooperatively promote gastric tumorigenesis in a preclinical model
by: Thiem, S., et al.
Published: (2016)

Effects of point mutations at positions 79, 85 and 91 of the nipah virus leader sequence to its minigenome expression
by: Poh, Lian-Yih, et al.
Published: (2011)

Characterisation of Pseudorabies Virus and Its Mutants
by: Allaudin, Zeenathul Nazariah
Published: (1999)

Watch out for new mutant strain
by: Vethasalam, Ragananthini
Published: (2023)

Amplified Fragment Length Polymorphism-Based Detection of Deoxyribonucleic Acid Methylation and the Analysis Of Three Mads-Box Genes In Oil Palm (Elaeis Guineensis Jacq.)
by: Au, Adelene Yong Shu Mei
Published: (2006)

PELAJAR ANTARABANGSA SAMBUT BAIK FUSE 2016
by: MPRC, Pusat Media & Perhubungan Awam
Published: (2016)

Endolysins against Streptococci as an antibiotic alternative
by: Wong, Kuan Yee, et al.
Published: (2022)