Cytotoxic and radiosensitising effects of a novel thioredoxin reductase inhibitor in breast cancer

QR Code

Cytotoxic and radiosensitising effects of a novel thioredoxin reductase inhibitor in breast cancer

Radiotherapy is an effective treatment modality for breast cancer but, unfortunately, not all patients respond fully with a significant number experiencing local recurrences. Overexpression of thioredoxin and thioredoxin reductase has been reported to cause multidrug and radiation resistance - their...

Full description

Bibliographic Details
Main Authors:	Abdullah, Nurul Akmaryanti, Inman, Martyn, Moody, Christopher J., Storr, Sarah J., Martin, Stewart G.
Format:	Article
Language:	English
Published:	Kluwer Academic Publishers 2021
Online Access:	http://psasir.upm.edu.my/id/eprint/96589/ http://psasir.upm.edu.my/id/eprint/96589/1/ABSTRACT.pdf

Similar Items

Targeting thioredoxin reductase in pancreatic cancer
by: Alhadyan, Khaled
Published: (2019)

Copper(II)-mediated synthesis of indolequinones from bromoquinones and enamines
by: Inman, Martyn, et al.
Published: (2013)

Thioredoxin system in colorectal cancer: Its role in carcinogenesis, disease progression, and response to treatment
by: Abdullah, Nurul Akmaryanti, et al.
Published: (2024)

Total synthesis of the cyclic dodecapeptides wewakazole and wewakazole B
by: Inman, Martyn, et al.
Published: (2017)

Thioredoxin interacting protein (TXNIP) is an independent risk stratifier for breast ductal carcinoma in situ
by: Miligy, Islam, et al.
Published: (2018)

A comparative study of adhesion of melanoma and breast cancer cells to blood and lymphatic endothelium
by: Safuan, Sabreena, et al.
Published: (2012)

Targeting thioredoxin system to improve radiotherapeutic response of brain cancers
by: Yao, Anqi
Published: (2020)

Analysis of transcriptomic changes that occur following loss of DARPP-32 expression in breast cancer
by: Storr, Sarah
Published: (2022)

The role of redox proteins in the radiotherapeutic response of breast cancer
by: Abdullah, Nurul Akmaryanti
Published: (2019)

Investigating the effects and mechanisms of HMG-CoA reductase inhibitor simvastatin on the human myometrium
by: Pang, Vincent
Published: (2017)

High nuclear MSK1 is associated with longer survival in breast cancer patients
by: Pu, Xuan, et al.
Published: (2018)

Macrophage-derived interleukin-1beta promotes human breast cancer cell migration and lymphatic adhesion in vitro
by: Storr, Sarah J., et al.
Published: (2017)

Caspase-3 and caspase-8 expression in breast cancer: caspase-3 is associated with survival
by: Xuan, Pu, et al.
Published: (2016)

IL-6 and IL-10 are associated with good prognosis in early stage invasive breast cancer patients
by: Ahmad, Narmeen, et al.
Published: (2018)

In silico analysis of Mentha pipertia (phyto-constituents) as HMG coa reductase and squalene synthase inhibitors
by: Narayanaswamy, Radhakrishnan, et al.
Published: (2018)

Albumin fusion of thioredoxin - The production and evaluation of its biological activity for potential therapeutic applications
by: Ikuta, S., et al.
Published: (2010)

Cloning, expression, and characterization of a novel xylose reductase from Rhizopus oryzae
by: Zhang, M., et al.
Published: (2015)

Role of novel therapeutic agents in modulating invadopodia formation in metastatic breast cancer
by: Siti Nor Aini Harun,, et al.
Published: (2020)

Identification and characterization of ferredoxin NADP+ reductase from Bacillus sp.
by: Othman, Sarah Syamimi
Published: (2015)

The calpain system is associated with survival of breast cancer patients with large but operable inflammatory and non-inflammatory tumours treated with neoadjuvant chemotherapy
by: Storr, Sarah J., et al.
Published: (2016)

The prognostic and predictive power of redox rotein expression for anthracycline-based chemotherapy response in locally advanced breast cancer
by: Woolston, Caroline M., et al.
Published: (2012)

An Innovative Strategy for Dual Inhibitor Design and Its Application in Dual Inhibition of Human Thymidylate Synthase and Dihydrofolate Reductase Enzymes
by: Arooj, Mahreen, et al.
Published: (2013)

Molybdenum reductase in Enterobacter cloacae
by: Ariff, Arbakariya, et al.
Published: (1997)

A human serum albumin–thioredoxin fusion protein prevents experimental contrast-induced nephropathy
by: Kodama, A., et al.
Published: (2013)

Albumin fusion prolongs the antioxidant and anti-inflammatory activities of thioredoxin in mice with acetaminophen-induced hepatitis
by: Tanaka, R., et al.
Published: (2014)

Methylenetetrahydrofolate reductase and methionine synthase reductase gene polymorphisms in Iranian ventricular septal defect subjects
by: Pishva, Seyyed Reza
Published: (2013)

Calpain system protein expression in basal-like and triple-negative invasive breast cancer
by: Storr, Sarah J., et al.
Published: (2012)

Identification of oestrone sulphatase inhibitors in breast cyst fluid: a new treatment for breast cancer
by: Lai, L. C.
Published: (1999)

Cytotoxic effect of dillapiole on human breast cancer MCF-7 cells
by: Indah Mohd Amin,, et al.
Published: (2022)

Cytotoxic effect of dillapiole on human breast cancer MCF-7 CELLS
by: Indah Mohd Amin,, et al.
Published: (2022)

Nordamnacanthal potentiates the cytotoxic effects of tamoxifen in human breast cancer cells
by: Mohamed Alitheen, Noorjahan Banu, et al.
Published: (2015)

Structure-based virtual screening towards the discovery of usnic acid derivatives as novel mTOR inhibitor to treat breast cancer
by: Wong, Kelvin Khai Voon, et al.
Published: (2022)

Binding mode analysis of dual inhibitors of human thymidylate synthase and dihydrofolate reductase as antitumour agents via molecular docking and DFT studies
by: Arooj, Mahreen, et al.
Published: (2015)

Cytotoxicity effect of solid lipid nanoparticle on human breast cancer cell lines
by: Abbasalipourkabirreh, Roghayeh, et al.
Published: (2011)

The cytotoxic effect and glucose uptake modulation of Baeckea frutescens on breast cancer cells
by: Shahruzaman, S. H., et al.
Published: (2019)

The cytotoxic effect of baeckea frustescens extracts in eliminating hypoxic breast cancer cells
by: Shahruzaman, S. H., et al.
Published: (2021)

Phytocompounds of Anonna muricata leaves extract and cytotoxic effects on breast cancer cells
by: Rahman, Husna Syakirah Ab, et al.
Published: (2018)

Analysis of cytochrome b5 reductase-mediated metabolism in the phytopathogenic fungus Zymoseptoria tritici reveals novel functionalities implicated in virulence
by: Derbyshire, Mark, et al.
Published: (2015)

Thioredoxin-albumin fusion protein prevents copper enhanced zinc-induced neurotoxicity via its antioxidative activity
by: Tanaka, K., et al.
Published: (2018)

Long-acting human serum albumin-thioredoxin fusion protein suppresses bleomycin-induced pulmonary fibrosis progression
by: Tanaka, R., et al.
Published: (2013)