Coinheritance of haemoglobin e trait with alpha thalassaemia among Malay students in national thalassaemia screening programme in Hospital Sultanah Nur Zahirah Kuala Terengganu
Introduction: Coinheritance of Hb E with alpha thalassaemia may occur. Individuals are asymptomatic for the condition. Further investigations for alpha thalassaemia coinherit with Hb E are dependent upon establishment in lower limit of RBC parameters together with haemoglobin analysis findings. Obje...
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Universiti Putra Malaysia
2021
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| Online Access: | http://psasir.upm.edu.my/id/eprint/96427/ |
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| author | Somasundram, Suguna Abdul Rahman, Alawiyah Idris, Faridah Mohd Tohit, Eusni Rahayu |
| author_facet | Somasundram, Suguna Abdul Rahman, Alawiyah Idris, Faridah Mohd Tohit, Eusni Rahayu |
| author_sort | Somasundram, Suguna |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Introduction: Coinheritance of Hb E with alpha thalassaemia may occur. Individuals are asymptomatic for the condition. Further investigations for alpha thalassaemia coinherit with Hb E are dependent upon establishment in lower limit of RBC parameters together with haemoglobin analysis findings. Objectives of the study were to determine coinheritance pattern of Hb E and alpha thalassaemia, significance of RBC parameters and possible cut off level for Hb E for further alpha thalassaemia investigations. Methods: This was a cross sectional study using retrospective data
among National Thalassaemia Screening Programme (NTSP) Form Four students. Individuals were classified into three groups (Hb E trait individuals with unknown alpha thalassaemia status, without alpha thalassaemia and with alpha thalassaemia). Descriptive data on gender, mean values of the RBC parameters, Hb A2 and Hb E levels were determined, followed by comparative analysis and ROC curve plotting to determine cut-off value to predict coinheritance of alpha thalassaemia in Hb E traits. Results: The male and female groups are almost equally distributed. Variability in the Hb A2, Hb E levels and RBC parameters values in between groups were noted and some values show significant differences. The cut-off Hb E level to predict the possibility of alpha thalassaemia in Hb E trait is 23.25 %. Conclusion: The proportion of Hb E trait in NTSP of Terengganu state was 17.7 %. Mean RBC parameters between
different groups in Hb E trait show variability in values. Hb E ≤23 % can be safely used as a cut-off value to predict coinheritance alpha thalassaemia in Hb E trait. |
| first_indexed | 2025-11-15T13:15:49Z |
| format | Article |
| id | upm-96427 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-15T13:15:49Z |
| publishDate | 2021 |
| publisher | Universiti Putra Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-964272023-02-10T01:48:41Z http://psasir.upm.edu.my/id/eprint/96427/ Coinheritance of haemoglobin e trait with alpha thalassaemia among Malay students in national thalassaemia screening programme in Hospital Sultanah Nur Zahirah Kuala Terengganu Somasundram, Suguna Abdul Rahman, Alawiyah Idris, Faridah Mohd Tohit, Eusni Rahayu Introduction: Coinheritance of Hb E with alpha thalassaemia may occur. Individuals are asymptomatic for the condition. Further investigations for alpha thalassaemia coinherit with Hb E are dependent upon establishment in lower limit of RBC parameters together with haemoglobin analysis findings. Objectives of the study were to determine coinheritance pattern of Hb E and alpha thalassaemia, significance of RBC parameters and possible cut off level for Hb E for further alpha thalassaemia investigations. Methods: This was a cross sectional study using retrospective data among National Thalassaemia Screening Programme (NTSP) Form Four students. Individuals were classified into three groups (Hb E trait individuals with unknown alpha thalassaemia status, without alpha thalassaemia and with alpha thalassaemia). Descriptive data on gender, mean values of the RBC parameters, Hb A2 and Hb E levels were determined, followed by comparative analysis and ROC curve plotting to determine cut-off value to predict coinheritance of alpha thalassaemia in Hb E traits. Results: The male and female groups are almost equally distributed. Variability in the Hb A2, Hb E levels and RBC parameters values in between groups were noted and some values show significant differences. The cut-off Hb E level to predict the possibility of alpha thalassaemia in Hb E trait is 23.25 %. Conclusion: The proportion of Hb E trait in NTSP of Terengganu state was 17.7 %. Mean RBC parameters between different groups in Hb E trait show variability in values. Hb E ≤23 % can be safely used as a cut-off value to predict coinheritance alpha thalassaemia in Hb E trait. Universiti Putra Malaysia 2021 Article PeerReviewed Somasundram, Suguna and Abdul Rahman, Alawiyah and Idris, Faridah and Mohd Tohit, Eusni Rahayu (2021) Coinheritance of haemoglobin e trait with alpha thalassaemia among Malay students in national thalassaemia screening programme in Hospital Sultanah Nur Zahirah Kuala Terengganu. Malaysian Journal of Medicine and Health Sciences, 17 (suppl.10). 45 - 53. ISSN 2636-9346 https://medic.upm.edu.my/jurnal_kami/volume_17_2021/mjmhs_vol17_supp_10_december_2021-64369 |
| spellingShingle | Somasundram, Suguna Abdul Rahman, Alawiyah Idris, Faridah Mohd Tohit, Eusni Rahayu Coinheritance of haemoglobin e trait with alpha thalassaemia among Malay students in national thalassaemia screening programme in Hospital Sultanah Nur Zahirah Kuala Terengganu |
| title | Coinheritance of haemoglobin e trait with alpha thalassaemia among Malay students in national thalassaemia screening programme in Hospital Sultanah Nur Zahirah Kuala Terengganu |
| title_full | Coinheritance of haemoglobin e trait with alpha thalassaemia among Malay students in national thalassaemia screening programme in Hospital Sultanah Nur Zahirah Kuala Terengganu |
| title_fullStr | Coinheritance of haemoglobin e trait with alpha thalassaemia among Malay students in national thalassaemia screening programme in Hospital Sultanah Nur Zahirah Kuala Terengganu |
| title_full_unstemmed | Coinheritance of haemoglobin e trait with alpha thalassaemia among Malay students in national thalassaemia screening programme in Hospital Sultanah Nur Zahirah Kuala Terengganu |
| title_short | Coinheritance of haemoglobin e trait with alpha thalassaemia among Malay students in national thalassaemia screening programme in Hospital Sultanah Nur Zahirah Kuala Terengganu |
| title_sort | coinheritance of haemoglobin e trait with alpha thalassaemia among malay students in national thalassaemia screening programme in hospital sultanah nur zahirah kuala terengganu |
| url | http://psasir.upm.edu.my/id/eprint/96427/ http://psasir.upm.edu.my/id/eprint/96427/ |