Chitosan nanoparticle-based system: a new insight into the promising controlled release system for lung cancer treatment
Lung cancer has been recognized as one of the most often diagnosed and perhaps most lethal cancer diseases worldwide. Conventional chemotherapy for lung cancer-related diseases has bumped into various limitations and challenges, including non-targeted drug delivery, short drug retention period, low...
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| Format: | Article |
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Multidisciplinary Digital Publishing Institute
2021
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| Online Access: | http://psasir.upm.edu.my/id/eprint/96390/ |
| _version_ | 1848862353686265856 |
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| author | Cha, Yee Kuen Masarudin, Mas Jaffri |
| author_facet | Cha, Yee Kuen Masarudin, Mas Jaffri |
| author_sort | Cha, Yee Kuen |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Lung cancer has been recognized as one of the most often diagnosed and perhaps most lethal cancer diseases worldwide. Conventional chemotherapy for lung cancer-related diseases has bumped into various limitations and challenges, including non-targeted drug delivery, short drug retention period, low therapeutic efficacy, and multidrug resistance (MDR). Chitosan (CS), a natural polymer derived from deacetylation of chitin, and comprised of arbitrarily distributed β-(1-4)-linked d-glucosamine (deacetylated unit) and N-acetyl-d-glucosamine (acetylated unit) that exhibits magnificent characteristics, including being mucoadhesive, biodegradable, and biocompatible, has emerged as an essential element for the development of a nano-particulate delivery vehicle. Additionally, the flexibility of CS structure due to the free protonable amino groups in the CS backbone has made it easy for the modification and functionalization of CS to be developed into a nanoparticle system with high adaptability in lung cancer treatment. In this review, the current state of chitosan nanoparticle (CNP) systems, including the advantages, challenges, and opportunities, will be discussed, followed by drug release mechanisms and mathematical kinetic models. Subsequently, various modification routes of CNP for improved and enhanced therapeutic efficacy, as well as other restrictions of conventional drug administration for lung cancer treatment, are covered. |
| first_indexed | 2025-11-15T13:15:41Z |
| format | Article |
| id | upm-96390 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-15T13:15:41Z |
| publishDate | 2021 |
| publisher | Multidisciplinary Digital Publishing Institute |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-963902023-01-26T08:00:13Z http://psasir.upm.edu.my/id/eprint/96390/ Chitosan nanoparticle-based system: a new insight into the promising controlled release system for lung cancer treatment Cha, Yee Kuen Masarudin, Mas Jaffri Lung cancer has been recognized as one of the most often diagnosed and perhaps most lethal cancer diseases worldwide. Conventional chemotherapy for lung cancer-related diseases has bumped into various limitations and challenges, including non-targeted drug delivery, short drug retention period, low therapeutic efficacy, and multidrug resistance (MDR). Chitosan (CS), a natural polymer derived from deacetylation of chitin, and comprised of arbitrarily distributed β-(1-4)-linked d-glucosamine (deacetylated unit) and N-acetyl-d-glucosamine (acetylated unit) that exhibits magnificent characteristics, including being mucoadhesive, biodegradable, and biocompatible, has emerged as an essential element for the development of a nano-particulate delivery vehicle. Additionally, the flexibility of CS structure due to the free protonable amino groups in the CS backbone has made it easy for the modification and functionalization of CS to be developed into a nanoparticle system with high adaptability in lung cancer treatment. In this review, the current state of chitosan nanoparticle (CNP) systems, including the advantages, challenges, and opportunities, will be discussed, followed by drug release mechanisms and mathematical kinetic models. Subsequently, various modification routes of CNP for improved and enhanced therapeutic efficacy, as well as other restrictions of conventional drug administration for lung cancer treatment, are covered. Multidisciplinary Digital Publishing Institute 2021 Article PeerReviewed Cha, Yee Kuen and Masarudin, Mas Jaffri (2021) Chitosan nanoparticle-based system: a new insight into the promising controlled release system for lung cancer treatment. Molecules, 27 (2). art. no. 473. pp. 1-27. ISSN 1420-3049 https://www.mdpi.com/1420-3049/27/2/473 10.3390/molecules27020473 |
| spellingShingle | Cha, Yee Kuen Masarudin, Mas Jaffri Chitosan nanoparticle-based system: a new insight into the promising controlled release system for lung cancer treatment |
| title | Chitosan nanoparticle-based system: a new insight into the promising controlled release system for lung cancer treatment |
| title_full | Chitosan nanoparticle-based system: a new insight into the promising controlled release system for lung cancer treatment |
| title_fullStr | Chitosan nanoparticle-based system: a new insight into the promising controlled release system for lung cancer treatment |
| title_full_unstemmed | Chitosan nanoparticle-based system: a new insight into the promising controlled release system for lung cancer treatment |
| title_short | Chitosan nanoparticle-based system: a new insight into the promising controlled release system for lung cancer treatment |
| title_sort | chitosan nanoparticle-based system: a new insight into the promising controlled release system for lung cancer treatment |
| url | http://psasir.upm.edu.my/id/eprint/96390/ http://psasir.upm.edu.my/id/eprint/96390/ http://psasir.upm.edu.my/id/eprint/96390/ |