Central composite design for formulation and optimization of solid lipid nanoparticles to enhance oral bioavailability of Acyclovir

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Central composite design for formulation and optimization of solid lipid nanoparticles to enhance oral bioavailability of Acyclovir

Treatment of herpes simplex infection requires high and frequent doses of oral acyclovir to attain its maximum therapeutic effect. The current therapeutic regimen of acyclovir is known to cause unwarranted dose-related adverse effects, including acute kidney injury. For this reason, a suitable deliv...

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Bibliographic Details
Main Authors:	Hassan, Haniza, Adam, Siti Khadijah, Alias, Ekram, Meor Mohd Affandi, Meor Mohd Redzuan, Shamsuddin, Ahmad Fuad, Basir, Rusliza
Format:	Article
Published:	Multidisciplinary Digital Publishing Institute 2021
Online Access:	http://psasir.upm.edu.my/id/eprint/96316/

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