A systematic review of the effects of Equol (Soy Metabolite) on breast cancer
Equol is a soy isoflavone metabolite that can be produced by intestinal bacteria. It is lipophilic and resembles natural oestrogens with an affinity to oestrogen receptors. This review is focused on how equol affects breast cancer, as evidenced by in vivo and in vitro studies. Equol is considered ch...
| Main Authors: | , , |
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| Format: | Article |
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Multidisciplinary Digital Publishing Institute
2021
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| Online Access: | http://psasir.upm.edu.my/id/eprint/96146/ |
| _version_ | 1848862303939723264 |
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| author | Hod, Rafidah Maniam, Sandra Mohd Nor, Nurul Huda |
| author_facet | Hod, Rafidah Maniam, Sandra Mohd Nor, Nurul Huda |
| author_sort | Hod, Rafidah |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Equol is a soy isoflavone metabolite that can be produced by intestinal bacteria. It is lipophilic and resembles natural oestrogens with an affinity to oestrogen receptors. This review is focused on how equol affects breast cancer, as evidenced by in vivo and in vitro studies. Equol is considered chemoprotective in specific endocrine-related pathologies, such as breast cancer, prostate cancer, cardiovascular diseases, and menopausal symptoms. In humans, not everyone can produce equol from gut metabolism. It is postulated that equol producers benefit more than non-equol producers for all the endocrine-related effects. Equol exists in two enantiomers of R-equol and S-equol. Earlier studies, however, did not specify which enantiomer was being used. This review considers equol’s type and concentration variations, pathways affected, and its outcome in in vivo and in vitro studies. |
| first_indexed | 2025-11-15T13:14:53Z |
| format | Article |
| id | upm-96146 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-15T13:14:53Z |
| publishDate | 2021 |
| publisher | Multidisciplinary Digital Publishing Institute |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-961462023-01-31T03:19:27Z http://psasir.upm.edu.my/id/eprint/96146/ A systematic review of the effects of Equol (Soy Metabolite) on breast cancer Hod, Rafidah Maniam, Sandra Mohd Nor, Nurul Huda Equol is a soy isoflavone metabolite that can be produced by intestinal bacteria. It is lipophilic and resembles natural oestrogens with an affinity to oestrogen receptors. This review is focused on how equol affects breast cancer, as evidenced by in vivo and in vitro studies. Equol is considered chemoprotective in specific endocrine-related pathologies, such as breast cancer, prostate cancer, cardiovascular diseases, and menopausal symptoms. In humans, not everyone can produce equol from gut metabolism. It is postulated that equol producers benefit more than non-equol producers for all the endocrine-related effects. Equol exists in two enantiomers of R-equol and S-equol. Earlier studies, however, did not specify which enantiomer was being used. This review considers equol’s type and concentration variations, pathways affected, and its outcome in in vivo and in vitro studies. Multidisciplinary Digital Publishing Institute 2021 Article PeerReviewed Hod, Rafidah and Maniam, Sandra and Mohd Nor, Nurul Huda (2021) A systematic review of the effects of Equol (Soy Metabolite) on breast cancer. Molecules, 26 (4). pp. 1-20. ISSN 1420-3049 https://www.mdpi.com/1420-3049/26/4/1105 10.3390/molecules26041105 |
| spellingShingle | Hod, Rafidah Maniam, Sandra Mohd Nor, Nurul Huda A systematic review of the effects of Equol (Soy Metabolite) on breast cancer |
| title | A systematic review of the effects of Equol (Soy Metabolite) on breast cancer |
| title_full | A systematic review of the effects of Equol (Soy Metabolite) on breast cancer |
| title_fullStr | A systematic review of the effects of Equol (Soy Metabolite) on breast cancer |
| title_full_unstemmed | A systematic review of the effects of Equol (Soy Metabolite) on breast cancer |
| title_short | A systematic review of the effects of Equol (Soy Metabolite) on breast cancer |
| title_sort | systematic review of the effects of equol (soy metabolite) on breast cancer |
| url | http://psasir.upm.edu.my/id/eprint/96146/ http://psasir.upm.edu.my/id/eprint/96146/ http://psasir.upm.edu.my/id/eprint/96146/ |