A review on biological properties and synthetic methodologies of Diarylpentadienones
Medicinal chemists have continuously shown interest in new curcuminoid derivatives, diarylpentadienones, owing to their enhanced stability feature and easy preparation using a one-pot synthesis. Thus far, methods such as Claisen-Schmidt condensation and Julia- Kocienski olefination have been utilise...
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| Format: | Article |
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Bentham Science
2021
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| Online Access: | http://psasir.upm.edu.my/id/eprint/96036/ |
| _version_ | 1848862284052430848 |
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| author | Abdullah, Maryam Aisyah Mohd Faudzi, Siti Munirah Mad Nasir, Nadiah |
| author_facet | Abdullah, Maryam Aisyah Mohd Faudzi, Siti Munirah Mad Nasir, Nadiah |
| author_sort | Abdullah, Maryam Aisyah |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Medicinal chemists have continuously shown interest in new curcuminoid derivatives, diarylpentadienones, owing to their enhanced stability feature and easy preparation using a one-pot synthesis. Thus far, methods such as Claisen-Schmidt condensation and Julia- Kocienski olefination have been utilised for the synthesis of these compounds. Diarylpentadienones possess a high potential as a chemical source for designing and developing new and effective drugs for the treatment of diseases, including inflammation, cancer, and malaria. In brief, this review article focuses on the broad pharmacological applications and the summary of the structure-activity relationship of molecules, which can be employed to further explore the structure of diarylpentadienone. The current methodological developments towards the synthesis of diarylpentadienones are also discussed. |
| first_indexed | 2025-11-15T13:14:34Z |
| format | Article |
| id | upm-96036 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-15T13:14:34Z |
| publishDate | 2021 |
| publisher | Bentham Science |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-960362023-03-08T07:16:21Z http://psasir.upm.edu.my/id/eprint/96036/ A review on biological properties and synthetic methodologies of Diarylpentadienones Abdullah, Maryam Aisyah Mohd Faudzi, Siti Munirah Mad Nasir, Nadiah Medicinal chemists have continuously shown interest in new curcuminoid derivatives, diarylpentadienones, owing to their enhanced stability feature and easy preparation using a one-pot synthesis. Thus far, methods such as Claisen-Schmidt condensation and Julia- Kocienski olefination have been utilised for the synthesis of these compounds. Diarylpentadienones possess a high potential as a chemical source for designing and developing new and effective drugs for the treatment of diseases, including inflammation, cancer, and malaria. In brief, this review article focuses on the broad pharmacological applications and the summary of the structure-activity relationship of molecules, which can be employed to further explore the structure of diarylpentadienone. The current methodological developments towards the synthesis of diarylpentadienones are also discussed. Bentham Science 2021 Article PeerReviewed Abdullah, Maryam Aisyah and Mohd Faudzi, Siti Munirah and Mad Nasir, Nadiah (2021) A review on biological properties and synthetic methodologies of Diarylpentadienones. Mini-Reviews in Medicinal Chemistry, 21 (9). 1058 - 1070. ISSN 1389-5575; ESSN: 1875-5607 https://www.eurekaselect.com/article/112045 10.2174/1389557520999201203213957 |
| spellingShingle | Abdullah, Maryam Aisyah Mohd Faudzi, Siti Munirah Mad Nasir, Nadiah A review on biological properties and synthetic methodologies of Diarylpentadienones |
| title | A review on biological properties and synthetic methodologies of Diarylpentadienones |
| title_full | A review on biological properties and synthetic methodologies of Diarylpentadienones |
| title_fullStr | A review on biological properties and synthetic methodologies of Diarylpentadienones |
| title_full_unstemmed | A review on biological properties and synthetic methodologies of Diarylpentadienones |
| title_short | A review on biological properties and synthetic methodologies of Diarylpentadienones |
| title_sort | review on biological properties and synthetic methodologies of diarylpentadienones |
| url | http://psasir.upm.edu.my/id/eprint/96036/ http://psasir.upm.edu.my/id/eprint/96036/ http://psasir.upm.edu.my/id/eprint/96036/ |