A review of the neuroprotective effects of andrographolide in Alzheimer's disease
Alzheimer’s disease, characterized by amyloid beta peptides and neurofibrillary tangles, is the most prevalent cause of dementia. Nowadays, some novel medicines being developed have displayed more illustrious therapeutic efficacies in Alzheimer’s disease. Recent studies have found andrographolide ex...
| Main Authors: | , , , , , |
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| Format: | Article |
| Published: |
Springer
2021
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| Online Access: | http://psasir.upm.edu.my/id/eprint/96019/ |
| _version_ | 1848862279565574144 |
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| author | Abedi, Zahra Hassan, Zurina Basri, Hamidon Inche Mat, Liyana Najwa Khaza’ai, Huzwah Mohamad, Nur Afiqah |
| author_facet | Abedi, Zahra Hassan, Zurina Basri, Hamidon Inche Mat, Liyana Najwa Khaza’ai, Huzwah Mohamad, Nur Afiqah |
| author_sort | Abedi, Zahra |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Alzheimer’s disease, characterized by amyloid beta peptides and neurofibrillary tangles, is the most prevalent cause of dementia. Nowadays, some novel medicines being developed have displayed more illustrious therapeutic efficacies in Alzheimer’s disease. Recent studies have found andrographolide exhibiting therapeutic efficacy in a variety of Alzheimer’s disease models. Andrographolide is a traditional herbal medicine compound extracted from Andrographis paniculata. Evidence has shown that andrographolide reduces amyloid beta aggregation and suppresses neuroinflammatory response and synaptic dysfunction by reversing the microglia-mediated production of pro-inflammatory cytokines as well as Alzheimer’s disease-associated reduction in synaptic proteins. In the present review, the pharmacological effects of andrographolide are summarized and its mechanism of action against Alzheimer’s disease is discussed to discover the possibilities of andrographolide for Alzheimer’s disease prevention and therapy. |
| first_indexed | 2025-11-15T13:14:30Z |
| format | Article |
| id | upm-96019 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-15T13:14:30Z |
| publishDate | 2021 |
| publisher | Springer |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-960192023-03-13T04:00:07Z http://psasir.upm.edu.my/id/eprint/96019/ A review of the neuroprotective effects of andrographolide in Alzheimer's disease Abedi, Zahra Hassan, Zurina Basri, Hamidon Inche Mat, Liyana Najwa Khaza’ai, Huzwah Mohamad, Nur Afiqah Alzheimer’s disease, characterized by amyloid beta peptides and neurofibrillary tangles, is the most prevalent cause of dementia. Nowadays, some novel medicines being developed have displayed more illustrious therapeutic efficacies in Alzheimer’s disease. Recent studies have found andrographolide exhibiting therapeutic efficacy in a variety of Alzheimer’s disease models. Andrographolide is a traditional herbal medicine compound extracted from Andrographis paniculata. Evidence has shown that andrographolide reduces amyloid beta aggregation and suppresses neuroinflammatory response and synaptic dysfunction by reversing the microglia-mediated production of pro-inflammatory cytokines as well as Alzheimer’s disease-associated reduction in synaptic proteins. In the present review, the pharmacological effects of andrographolide are summarized and its mechanism of action against Alzheimer’s disease is discussed to discover the possibilities of andrographolide for Alzheimer’s disease prevention and therapy. Springer 2021 Article PeerReviewed Abedi, Zahra and Hassan, Zurina and Basri, Hamidon and Inche Mat, Liyana Najwa and Khaza’ai, Huzwah and Mohamad, Nur Afiqah (2021) A review of the neuroprotective effects of andrographolide in Alzheimer's disease. Advances in Traditional Medicine, 21. pp. 253-266. ISSN 2662-4060 https://link.springer.com/article/10.1007/s13596-021-00573-8 10.1007/s13596-021-00573-8 |
| spellingShingle | Abedi, Zahra Hassan, Zurina Basri, Hamidon Inche Mat, Liyana Najwa Khaza’ai, Huzwah Mohamad, Nur Afiqah A review of the neuroprotective effects of andrographolide in Alzheimer's disease |
| title | A review of the neuroprotective effects of andrographolide in Alzheimer's disease |
| title_full | A review of the neuroprotective effects of andrographolide in Alzheimer's disease |
| title_fullStr | A review of the neuroprotective effects of andrographolide in Alzheimer's disease |
| title_full_unstemmed | A review of the neuroprotective effects of andrographolide in Alzheimer's disease |
| title_short | A review of the neuroprotective effects of andrographolide in Alzheimer's disease |
| title_sort | review of the neuroprotective effects of andrographolide in alzheimer's disease |
| url | http://psasir.upm.edu.my/id/eprint/96019/ http://psasir.upm.edu.my/id/eprint/96019/ http://psasir.upm.edu.my/id/eprint/96019/ |