Antinociceptive activities of a novel diarylpentanoid analogue, 2-benzoyl-6-(3-bromo-4-hydroxybenzylidene)cyclohexen-1-ol, and its possible mechanisms of action in mice

QR Code

Antinociceptive activities of a novel diarylpentanoid analogue, 2-benzoyl-6-(3-bromo-4-hydroxybenzylidene)cyclohexen-1-ol, and its possible mechanisms of action in mice

A novel synthetic compound from the 2-benzoyl-6-benzylidenecyclohexanone analogue, namely 2-benzoyl-6-(3-bromo-4-hydroxybenzylidene)cyclohexen-1-ol (BBHC), showed pronounced nitric oxide inhibition in IFN-γ/LPS-induced RAW 264.7 cells. Based on this previous finding, our present study aimed to inves...

Full description

Bibliographic Details
Main Authors:	Ong, Hui Ming, Ahmad Azmi, Ahmad Farhan, Sze, Wei Leong, Abas, Faridah, Perimal, Enoch Kumar, Omar Farouk, Ahmad Akira, Ahmad Israf, Daud, Sulaiman, Mohd Roslan
Format:	Article
Published:	Nature Research 2021
Online Access:	http://psasir.upm.edu.my/id/eprint/95923/

Similar Items

Antinociceptive activity of 2-benzoyl-6-(3-bromo-4-hydroxybenzylidene)cyclohexen-1-ol in mice
by: Ong, Hui Ming, et al.
Published: (2016)

Evaluation of antinociceptive activity of 2-benzoyl-6-(3-bromo-4-hydroxybenzylidene)cyclohexen-1-ol and its possible mechanisms of action in mice
by: Ong, Hui Ming
Published: (2021)

In vivo evaluation of antinociceptive activities of 2-benzoyl-6-(3,4-dihydroxybenzylidene)cyclohexen-1-Ol and its possible mechanism of actions
by: Ahmad Azmi, Ahmad Farhan
Published: (2021)

Antinociceptive effect of the essential oil of Zingiber zerumbet in mice : possible mechanisms
by: Khalid, Mohamed Hanief, et al.
Published: (2011)

The involvement of L-arginine-nitric ox-ide-cGMP-ATP-sensitive K+ channel pathway in antinocicep-tion of BBHC, a novel diarylpentanoid analogue, in mice model
by: Hui, Ming Ong, et al.
Published: (2021)

Antinociceptive Effects of Cardamonin in Mice: Possible Involvement of TRPV1, Glutamate, and Opioid Receptors
by: Chung, Pui Ping, et al.
Published: (2018)

Antinociceptive effects of cardamonin in mice: Possible involvement of TRPV1, glutamate and opioid receptors
by: Chung, Pui Ping, et al.
Published: (2018)

Antinociceptive activity of a synthetic curcuminoid analogue, 2,6-bis-(4-hydroxy-3-methoxybenzylidene)cyclohexanone, on nociception-induced models in mice.
by: Lee, Ming Tatt, et al.
Published: (2012)

Antinociceptive and Anti-Inflammatory Activities of Zerumbone from Zingiber Zerumbet (l.) Roscoe ex sm., and its Possible Mechanisms of Action
by: Perimal, Enoch Kumar
Published: (2012)

Molecular pathways modulated by curcumin analogue, diarylpentanoids in cancer
by: Paulraj, Felicia Simone, et al.
Published: (2019)

Peripheral antinociception of a chalcone, flavokawin B and possible involvement of the nitric oxide/cyclic guanosine monophosphate/potassium channels pathway
by: Kamaldin, Mohd Nasier, et al.
Published: (2013)

Synthesis and biological evaluation of curcumin-like diarylpentanoid analogues for anti-inflammatory, antioxidant and anti-tyrosinase activities
by: Ka-Heng, Lee, et al.
Published: (2009)

Peripheral Antinociception of a Chalcone, Flavokawin B and Possible Involvement of the Nitric Oxide/Cyclic Guanosine Monophosphate/Potassium Channels Pathway
by: Akhtar, Muhammad Nadeem, et al.
Published: (2013)

Synthesis and sar study of diarylpentanoid analogues as new anti-inflammatory agents
by: Leong, Sze Wei, et al.
Published: (2014)

Synthesis and SAR study of diarylpentanoid analogues as new anti-inflammatory agents
by: Leong, Sze Wei, et al.
Published: (2014)

Effect of diarylpentanoid analogues on lipopolysaccharide-induced interleukin-6 and interleukin-8 gene expression in airway inflammation
by: Liew, Kong Yen, et al.
Published: (2019)

Synthesis, biological evaluation and QSAR studies of diarylpentanoid analogues as potential nitric oxideinhibitors
by: Mohd Faudzi, Siti Munirah Mohd Faudzi, et al.
Published: (2015)

Synthesis, biological evaluation and QSAR studies of diarylpentanoid analogues as potential nitric oxide inhibitors
by: Mohd Faudzi, S. M., et al.
Published: (2015)

Nitric oxide inhibitory activity and antioxidant evaluations of 2-benzoyl-6-benzylidenecyclohexanone analogs, a novel series of curcuminoid and diarylpentanoid derivatives
by: Leong, Sze Wei, et al.
Published: (2015)

Possible participation of nitric oxide/cyclic guanosine monophosphate/protein kinase C/ATP-sensitive K + channels pathway in the systemic antinociception of flavokawin B.
by: Tengku Mohamad, Tengku Azam Shah, et al.
Published: (2011)

Antinociceptive effect of 3-(2,3-dimethoxyphenyl)-1-(5-methylfuran-2-yl)prop-2-en-1-one in mice models of induced nociception
by: Ismail, Nur Izzati, et al.
Published: (2016)

Possible participation of ionotropic glutamate receptors and L-arginine-nitric oxide-cyclic guanosine monophosphate-ATP-sensitive K+ channel pathway in the antinociceptive activity of cardamonin in acute pain animal models
by: Chung, Pui Ping, et al.
Published: (2020)

Possible participation of ionotropic glutamate receptors and l-arginine-nitric oxide-cyclic guanosine monophosphate-ATP-Sensitive K+ channel pathway in the antinociceptive activity of cardamonin in acute pain animal models
by: Chung, Pui Ping, et al.
Published: (2020)

Preliminary analysis of the antinociceptive activity of zerumbone
by: Sulaiman, Mohd Roslan, et al.
Published: (2009)

Antinociceptive Effect of 3-(2,3-Dimethoxyphenyl)-1-(5-methylfuran-2-yl)prop-2-en-1-one in Mice Models of Induced Nociception
by: Nur Izzati, Ismail, et al.
Published: (2016)

Antipruritic properties of topical Channa striatus extract on stratum corneum disruption-itch mice model
by: Fauzi, Irfan, et al.
Published: (2022)

Anti-hyperalgesic effect of a benzilidine-cyclohexanone analogue on a mouse model of chronic constriction injury-induced neuropathic pain: participation of the κ-opioid receptor and KATP
by: Lee, Ming Tatt, et al.
Published: (2013)

Antinociceptive activity of a synthetic chalcone, flavokawin B on chemical and thermal models of nociception in mice
by: Tengku Mohamad, Tengku Azam Shah, et al.
Published: (2010)

Antinociceptive activity of Melicope ptefolia ethanolic extract in experimental animals
by: Sulaiman, Mohd Roslan, et al.
Published: (2010)

Antinociceptive activity of Melicope ptelefolia ethanolic extract in experimental animals.
by: Sulaiman, Mohd Roslan, et al.
Published: (2010)

Preliminary study on antinociceptove effect of aqueous extract of Boesenbergia pandurata in formalin-induced nociception test in mice
by: Ee, Ai Chin, et al.
Published: (2014)

Possible mechanisms of antinociception of methanol extract of Melastoma malabathricum leaves
by: Shah Jaois, Erman, et al.
Published: (2016)

Possible mechanisms of antinociception of methanol extract of Melastoma malabathricum leaves
by: Jaios, Erman Shah, et al.
Published: (2016)

Possible Antinociceptive Mechanism and Site of Activity of Haruan (Channa Striatus) Crude Aqueous Extract in Mice
by: Zakaria, Zainul Amiruddin
Published: (2005)

Antinociceptive activity of methanolic extract of Acmella uliginosa (Sw.) Cass.
by: Ong, Hui Ming, et al.
Published: (2011)

Anti-hyperalgesic Effect of a Benzilidine-cyclohexanone Analogue on a Mouse Model of Chronic Constriction Injury-induced Neuropathic Pain: Participation of the Îº-opioid Receptor and KATP
by: Akhtar, Muhammad Nadeem, et al.
Published: (2013)

Activity of cardamonin on chemical model of nociception in mice
by: Chung, Pui Ping, et al.
Published: (2014)

Cardamonin attenuates hyperalgesia and allodynia in a mouse model of chronic constriction injury-induced neuropathic pain: possible involvement of the opioid system
by: Sambasevam, Yogesvari, et al.
Published: (2016)

1-Chloro-4-[2-(4-chlorophenyl)ethyl]benzene and its bromo analogue: crystal structure, Hirshfeld surface analysis and computational chemistry
by: Jotani, Mukesh M., et al.
Published: (2019)

Synthesis, Characterization and Chromogenic Properties of 4-Hydroxy-(2-Hydroxybenzylidene) Benzohydrazide
by: Rassem, Hesham H. A., et al.
Published: (2015)