An insight on the future therapeutic application potential of Stevia rebaudiana Bertoni for atherosclerosis and cardiovascular diseases
Stevia rebaudiana Bertoni is a native plant to Paraguay. The extracts have been used as a famous sweetening agent, and the bioactive components derived from stevia possess a broad spectrum of therapeutical potential for various illnesses. Among its medicinal benefits are anti-hypertensive, anti-tumo...
| Main Authors: | , , , , , |
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| Format: | Article |
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Elsevier
2021
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| Online Access: | http://psasir.upm.edu.my/id/eprint/95861/ |
| _version_ | 1848862238037770240 |
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| author | Ilias, Nazhan Hamzah, Hazilawati Ismail, Intan Safinar Mohd. Mohidin, Taznim Begam Idris, Mohd. Faiz Ajat, Mokrish |
| author_facet | Ilias, Nazhan Hamzah, Hazilawati Ismail, Intan Safinar Mohd. Mohidin, Taznim Begam Idris, Mohd. Faiz Ajat, Mokrish |
| author_sort | Ilias, Nazhan |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Stevia rebaudiana Bertoni is a native plant to Paraguay. The extracts have been used as a famous sweetening agent, and the bioactive components derived from stevia possess a broad spectrum of therapeutical potential for various illnesses. Among its medicinal benefits are anti-hypertensive, anti-tumorigenic, anti-diabetic, and anti-hyperlipidemia. Statins (3-hydro-3-methylglutaryl-coenzyme A reductase inhibitor) are a class of drugs used to treat atherosclerosis. Statins are explicitly targeting the HMG-CoA reductase, an enzyme in the rate-limiting step of cholesterol biosynthesis. Despite being widely used in regulating plasma cholesterol levels, the adverse effects of the drug are a significant concern among clinicians and patients. Hence, steviol glycosides derived from stevia have been proposed as an alternative in replacing statins. Diterpene glycosides from stevia, such as stevioside and rebaudioside A have been evaluated for their efficacy in alleviating cholesterol levels. These glycosides are a potential candidate in treating and preventing atherosclerosis provoked by circulating lipid retention in the sub-endothelial lining of the artery. The present review is an effort to integrate the pathogenesis of atherosclerosis, involvement of lipid droplets biogenesis and its associated proteins in atherogenesis, current approaches to treat atherosclerosis, and pharmacological potential of stevia in treating the disease. |
| first_indexed | 2025-11-15T13:13:50Z |
| format | Article |
| id | upm-95861 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-15T13:13:50Z |
| publishDate | 2021 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-958612023-03-29T04:16:57Z http://psasir.upm.edu.my/id/eprint/95861/ An insight on the future therapeutic application potential of Stevia rebaudiana Bertoni for atherosclerosis and cardiovascular diseases Ilias, Nazhan Hamzah, Hazilawati Ismail, Intan Safinar Mohd. Mohidin, Taznim Begam Idris, Mohd. Faiz Ajat, Mokrish Stevia rebaudiana Bertoni is a native plant to Paraguay. The extracts have been used as a famous sweetening agent, and the bioactive components derived from stevia possess a broad spectrum of therapeutical potential for various illnesses. Among its medicinal benefits are anti-hypertensive, anti-tumorigenic, anti-diabetic, and anti-hyperlipidemia. Statins (3-hydro-3-methylglutaryl-coenzyme A reductase inhibitor) are a class of drugs used to treat atherosclerosis. Statins are explicitly targeting the HMG-CoA reductase, an enzyme in the rate-limiting step of cholesterol biosynthesis. Despite being widely used in regulating plasma cholesterol levels, the adverse effects of the drug are a significant concern among clinicians and patients. Hence, steviol glycosides derived from stevia have been proposed as an alternative in replacing statins. Diterpene glycosides from stevia, such as stevioside and rebaudioside A have been evaluated for their efficacy in alleviating cholesterol levels. These glycosides are a potential candidate in treating and preventing atherosclerosis provoked by circulating lipid retention in the sub-endothelial lining of the artery. The present review is an effort to integrate the pathogenesis of atherosclerosis, involvement of lipid droplets biogenesis and its associated proteins in atherogenesis, current approaches to treat atherosclerosis, and pharmacological potential of stevia in treating the disease. Elsevier 2021 Article PeerReviewed Ilias, Nazhan and Hamzah, Hazilawati and Ismail, Intan Safinar and Mohd. Mohidin, Taznim Begam and Idris, Mohd. Faiz and Ajat, Mokrish (2021) An insight on the future therapeutic application potential of Stevia rebaudiana Bertoni for atherosclerosis and cardiovascular diseases. Biomedicine and Pharmacotherapy, 143. art. no. 112207. pp. 1-12. ISSN 0753-3322 https://www.sciencedirect.com/science/article/pii/S0753332221009914 10.1016/j.biopha.2021.112207 |
| spellingShingle | Ilias, Nazhan Hamzah, Hazilawati Ismail, Intan Safinar Mohd. Mohidin, Taznim Begam Idris, Mohd. Faiz Ajat, Mokrish An insight on the future therapeutic application potential of Stevia rebaudiana Bertoni for atherosclerosis and cardiovascular diseases |
| title | An insight on the future therapeutic application potential of Stevia rebaudiana Bertoni for atherosclerosis and cardiovascular diseases |
| title_full | An insight on the future therapeutic application potential of Stevia rebaudiana Bertoni for atherosclerosis and cardiovascular diseases |
| title_fullStr | An insight on the future therapeutic application potential of Stevia rebaudiana Bertoni for atherosclerosis and cardiovascular diseases |
| title_full_unstemmed | An insight on the future therapeutic application potential of Stevia rebaudiana Bertoni for atherosclerosis and cardiovascular diseases |
| title_short | An insight on the future therapeutic application potential of Stevia rebaudiana Bertoni for atherosclerosis and cardiovascular diseases |
| title_sort | insight on the future therapeutic application potential of stevia rebaudiana bertoni for atherosclerosis and cardiovascular diseases |
| url | http://psasir.upm.edu.my/id/eprint/95861/ http://psasir.upm.edu.my/id/eprint/95861/ http://psasir.upm.edu.my/id/eprint/95861/ |