Alteration of endogenous fatty acids profile and lipid metabolism in rats caused by a high-colleseed oil and a high-sunflower oil diet
Dietary fat has an important influence on mammalian lipid homeostasis. However, the relationship between dietary fat types and endogenous fatty acids (FAs) in organs as well as lipid homeostasis remains unclear enough. In this study, rats are randomly divided into a control group (CN), a high-colles...
| Main Authors: | , , , |
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| Format: | Article |
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Wiley-VCH Verlag
2021
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| Online Access: | http://psasir.upm.edu.my/id/eprint/95769/ |
| _version_ | 1848862217565372416 |
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| author | Li, Ruizhi Tan, Chin Ping Xu, Yong Jiang Liu, Yuanfa |
| author_facet | Li, Ruizhi Tan, Chin Ping Xu, Yong Jiang Liu, Yuanfa |
| author_sort | Li, Ruizhi |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Dietary fat has an important influence on mammalian lipid homeostasis. However, the relationship between dietary fat types and endogenous fatty acids (FAs) in organs as well as lipid homeostasis remains unclear enough. In this study, rats are randomly divided into a control group (CN), a high-colleseed oil group (COG), and a high-sunflower oil group (SOG). FAs profile in liver and visceral fats of rats in two high-fat (HF) diet groups is compared with that in CN. Oleic, γ-linolenic, eicosadienoic, and arachidonic acid accumulate in COG liver or visceral fats, but the levels of linoleic, eicosadienoic, docosanoic, and dihomo-γ-linolenic acid decrease in COG visceral fats. However, these FAs levels increased in SOG liver or visceral fats except dihomo-γ-linolenic and arachidonic acid which changed insignificantly. The trend of initial upregulation and then downregulation of lipid metabolism-related genes expression is noted in COG liver, including stearoyl-CoA desaturase. Upregulation of adiponectin (ADPN) expression in visceral fats and downregulation of ADPN receptor 2 (Adipo-R2) expression in livers of both HF groups are observed. Correlation analysis revealed positive correlations between specific FAs content and ADPN expression level. Negative correlations are observed between Adipo-R2 expression and the content of oleic, linoleic, and γ-linolenic acid in the SOG liver. |
| first_indexed | 2025-11-15T13:13:31Z |
| format | Article |
| id | upm-95769 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-15T13:13:31Z |
| publishDate | 2021 |
| publisher | Wiley-VCH Verlag |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-957692023-04-04T06:54:02Z http://psasir.upm.edu.my/id/eprint/95769/ Alteration of endogenous fatty acids profile and lipid metabolism in rats caused by a high-colleseed oil and a high-sunflower oil diet Li, Ruizhi Tan, Chin Ping Xu, Yong Jiang Liu, Yuanfa Dietary fat has an important influence on mammalian lipid homeostasis. However, the relationship between dietary fat types and endogenous fatty acids (FAs) in organs as well as lipid homeostasis remains unclear enough. In this study, rats are randomly divided into a control group (CN), a high-colleseed oil group (COG), and a high-sunflower oil group (SOG). FAs profile in liver and visceral fats of rats in two high-fat (HF) diet groups is compared with that in CN. Oleic, γ-linolenic, eicosadienoic, and arachidonic acid accumulate in COG liver or visceral fats, but the levels of linoleic, eicosadienoic, docosanoic, and dihomo-γ-linolenic acid decrease in COG visceral fats. However, these FAs levels increased in SOG liver or visceral fats except dihomo-γ-linolenic and arachidonic acid which changed insignificantly. The trend of initial upregulation and then downregulation of lipid metabolism-related genes expression is noted in COG liver, including stearoyl-CoA desaturase. Upregulation of adiponectin (ADPN) expression in visceral fats and downregulation of ADPN receptor 2 (Adipo-R2) expression in livers of both HF groups are observed. Correlation analysis revealed positive correlations between specific FAs content and ADPN expression level. Negative correlations are observed between Adipo-R2 expression and the content of oleic, linoleic, and γ-linolenic acid in the SOG liver. Wiley-VCH Verlag 2021 Article PeerReviewed Li, Ruizhi and Tan, Chin Ping and Xu, Yong Jiang and Liu, Yuanfa (2021) Alteration of endogenous fatty acids profile and lipid metabolism in rats caused by a high-colleseed oil and a high-sunflower oil diet. European Journal of Lipid Science and Technology, 123 (12). pp. 1-14. ISSN 1438-7697; ESSN: 1438-9312 https://onlinelibrary.wiley.com/doi/abs/10.1002/ejlt.202100100 10.1002/ejlt.202100100 |
| spellingShingle | Li, Ruizhi Tan, Chin Ping Xu, Yong Jiang Liu, Yuanfa Alteration of endogenous fatty acids profile and lipid metabolism in rats caused by a high-colleseed oil and a high-sunflower oil diet |
| title | Alteration of endogenous fatty acids profile and lipid metabolism in rats caused by a high-colleseed oil and a high-sunflower oil diet |
| title_full | Alteration of endogenous fatty acids profile and lipid metabolism in rats caused by a high-colleseed oil and a high-sunflower oil diet |
| title_fullStr | Alteration of endogenous fatty acids profile and lipid metabolism in rats caused by a high-colleseed oil and a high-sunflower oil diet |
| title_full_unstemmed | Alteration of endogenous fatty acids profile and lipid metabolism in rats caused by a high-colleseed oil and a high-sunflower oil diet |
| title_short | Alteration of endogenous fatty acids profile and lipid metabolism in rats caused by a high-colleseed oil and a high-sunflower oil diet |
| title_sort | alteration of endogenous fatty acids profile and lipid metabolism in rats caused by a high-colleseed oil and a high-sunflower oil diet |
| url | http://psasir.upm.edu.my/id/eprint/95769/ http://psasir.upm.edu.my/id/eprint/95769/ http://psasir.upm.edu.my/id/eprint/95769/ |