The IntelliCage system: a review of its utility as a novel behavioral platform for a rodent model of substance use disorder
The use of animal models for substance use disorder (SUD) has made an important contribution in the investigation of the behavioral and molecular mechanisms underlying substance abuse and addiction. Here, we review a novel and comprehensive behavioral platform to characterize addiction-like traits i...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Research Foundation
2021
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| Online Access: | http://psasir.upm.edu.my/id/eprint/95505/ http://psasir.upm.edu.my/id/eprint/95505/1/The%20IntelliCage%20system%20a%20review%20of%20its%20utility%20as%20a%20novel%20behavioral%20platform%20for%20a%20rodent%20model%20of%20substance%20use%20disorder.pdf |
| _version_ | 1848862174869454848 |
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| author | Nurul Iman, Ismail Mohd Yusof, Nurul Aiman Talib, Ummi Nasrah Ahmad, Nur Aimi Zawami Norazit, Anwar Kumar, Jaya Mehat, Muhammad Zulfadli Jayabalan, Nanthini Muthuraju, Sangu Stefaniuk, Marzena Kaczmarek, Leszek Muzaimi, Mustapha |
| author_facet | Nurul Iman, Ismail Mohd Yusof, Nurul Aiman Talib, Ummi Nasrah Ahmad, Nur Aimi Zawami Norazit, Anwar Kumar, Jaya Mehat, Muhammad Zulfadli Jayabalan, Nanthini Muthuraju, Sangu Stefaniuk, Marzena Kaczmarek, Leszek Muzaimi, Mustapha |
| author_sort | Nurul Iman, Ismail |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | The use of animal models for substance use disorder (SUD) has made an important contribution in the investigation of the behavioral and molecular mechanisms underlying substance abuse and addiction. Here, we review a novel and comprehensive behavioral platform to characterize addiction-like traits in rodents using a fully automated learning system, the IntelliCage. This system simultaneously captures the basic behavioral navigation, reward preference, and aversion, as well as the multi-dimensional complex behaviors and cognitive functions of group-housed rodents. It can reliably capture and track locomotor and cognitive pattern alterations associated with the development of substance addiction. Thus, the IntelliCage learning system offers a potentially efficient, flexible, and sensitive tool for the high-throughput screening of the rodent SUD model. |
| first_indexed | 2025-11-15T13:12:50Z |
| format | Article |
| id | upm-95505 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T13:12:50Z |
| publishDate | 2021 |
| publisher | Frontiers Research Foundation |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-955052022-12-28T08:37:23Z http://psasir.upm.edu.my/id/eprint/95505/ The IntelliCage system: a review of its utility as a novel behavioral platform for a rodent model of substance use disorder Nurul Iman, Ismail Mohd Yusof, Nurul Aiman Talib, Ummi Nasrah Ahmad, Nur Aimi Zawami Norazit, Anwar Kumar, Jaya Mehat, Muhammad Zulfadli Jayabalan, Nanthini Muthuraju, Sangu Stefaniuk, Marzena Kaczmarek, Leszek Muzaimi, Mustapha The use of animal models for substance use disorder (SUD) has made an important contribution in the investigation of the behavioral and molecular mechanisms underlying substance abuse and addiction. Here, we review a novel and comprehensive behavioral platform to characterize addiction-like traits in rodents using a fully automated learning system, the IntelliCage. This system simultaneously captures the basic behavioral navigation, reward preference, and aversion, as well as the multi-dimensional complex behaviors and cognitive functions of group-housed rodents. It can reliably capture and track locomotor and cognitive pattern alterations associated with the development of substance addiction. Thus, the IntelliCage learning system offers a potentially efficient, flexible, and sensitive tool for the high-throughput screening of the rodent SUD model. Frontiers Research Foundation 2021 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/95505/1/The%20IntelliCage%20system%20a%20review%20of%20its%20utility%20as%20a%20novel%20behavioral%20platform%20for%20a%20rodent%20model%20of%20substance%20use%20disorder.pdf Nurul Iman, Ismail and Mohd Yusof, Nurul Aiman and Talib, Ummi Nasrah and Ahmad, Nur Aimi Zawami and Norazit, Anwar and Kumar, Jaya and Mehat, Muhammad Zulfadli and Jayabalan, Nanthini and Muthuraju, Sangu and Stefaniuk, Marzena and Kaczmarek, Leszek and Muzaimi, Mustapha (2021) The IntelliCage system: a review of its utility as a novel behavioral platform for a rodent model of substance use disorder. Frontiers in Behavioral Neuroscience, 15 (-). pp. 1-13. ISSN ESSN:1662-5153 https://www.frontiersin.org/articles/10.3389/fnbeh.2021.683780/full 10.3389/fnbeh.2021.683780 |
| spellingShingle | Nurul Iman, Ismail Mohd Yusof, Nurul Aiman Talib, Ummi Nasrah Ahmad, Nur Aimi Zawami Norazit, Anwar Kumar, Jaya Mehat, Muhammad Zulfadli Jayabalan, Nanthini Muthuraju, Sangu Stefaniuk, Marzena Kaczmarek, Leszek Muzaimi, Mustapha The IntelliCage system: a review of its utility as a novel behavioral platform for a rodent model of substance use disorder |
| title | The IntelliCage system: a review of its utility as a novel behavioral platform for a rodent model of substance use disorder |
| title_full | The IntelliCage system: a review of its utility as a novel behavioral platform for a rodent model of substance use disorder |
| title_fullStr | The IntelliCage system: a review of its utility as a novel behavioral platform for a rodent model of substance use disorder |
| title_full_unstemmed | The IntelliCage system: a review of its utility as a novel behavioral platform for a rodent model of substance use disorder |
| title_short | The IntelliCage system: a review of its utility as a novel behavioral platform for a rodent model of substance use disorder |
| title_sort | intellicage system: a review of its utility as a novel behavioral platform for a rodent model of substance use disorder |
| url | http://psasir.upm.edu.my/id/eprint/95505/ http://psasir.upm.edu.my/id/eprint/95505/ http://psasir.upm.edu.my/id/eprint/95505/ http://psasir.upm.edu.my/id/eprint/95505/1/The%20IntelliCage%20system%20a%20review%20of%20its%20utility%20as%20a%20novel%20behavioral%20platform%20for%20a%20rodent%20model%20of%20substance%20use%20disorder.pdf |