The global prevalence of osteoporosis in the world: a comprehensive systematic review and meta-analysis
Background Osteoporosis affects all sections of society, including families with people affected by osteoporosis, government agencies and medical institutes in various fields. For example, it involves the patient and his/her family members, and government agencies in terms of the cost of treatment a...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BioMed Central
2021
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| Online Access: | http://psasir.upm.edu.my/id/eprint/95447/ http://psasir.upm.edu.my/id/eprint/95447/1/The%20global%20prevalence%20of%20osteoporosis%20in%20the%20world%20a%20comprehensive%20systematic%20review%20and%20meta-analysis.pdf |
| _version_ | 1848862162483675136 |
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| author | Salari, Nader Ghasemi, Hooman Mohammadi, Loghman Behzadi, Mohammad hasan Rabieenia, Elham Shohaimi, Shamarina Mohammadi, Masoud |
| author_facet | Salari, Nader Ghasemi, Hooman Mohammadi, Loghman Behzadi, Mohammad hasan Rabieenia, Elham Shohaimi, Shamarina Mohammadi, Masoud |
| author_sort | Salari, Nader |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Background Osteoporosis affects all sections of society, including families with people affected by osteoporosis, government agencies and medical institutes in various fields. For example, it involves the patient and his/her family members, and government agencies in terms of the cost of treatment and medical care. Providing a comprehensive picture of the prevalence of osteoporosis globally is important for health policymakers to make appropriate decisions. Therefore, this study was conducted to investigate the prevalence of osteoporosis worldwide. Methods A systematic review and meta-analysis were conducted in accordance with the PRISMA criteria. The PubMed, Science Direct, Web of Science, Scopus, Magiran, and Google Scholar databases were searched with no lower time limit up till 26 August 2020. The heterogeneity of the studies was measured using the I2 test, and the publication bias was assessed by the Begg and Mazumdar’s test at the significance level of 0.1. Results After following the systematic review processes, 86 studies were selected for meta-analysis. The sample size of the study was 103,334,579 people in the age range of 15–105 years. Using meta-analysis, the prevalence of osteoporosis in the world was reported to be 18.3 (95% CI 16.2–20.7). Based on 70 studies and sample size of 800,457 women, and heterogenicity I2: 99.8, the prevalence of osteoporosis in women of the world was reported to be 23.1 (95% CI 19.8–26.9), while the prevalence of osteoporosis among men of the world was found to be 11.7 (95% CI 9.6–14.1 which was based on 40 studies and sample size of 453,964 men.). The highest prevalence of osteoporosis was reported in Africa with 39.5% (95% CI 22.3–59.7) and a sample size of 2989 people with the age range 18–95 years. Conclusion According to the medical, economic, and social burden of osteoporosis, providing a robust and comprehensive estimate of the prevalence of osteoporosis in the world can facilitate decisions in health system planning and policymaking, including an overview of the current and outlook for the future; provide the necessary facilities for the treatment of people with osteoporosis; reduce the severe risks that lead to death by preventing fractures; and, finally, monitor the overall state of osteoporosis in the world. This study is the first to report a structured review and meta-analysis of the prevalence of osteoporosis worldwide. |
| first_indexed | 2025-11-15T13:12:38Z |
| format | Article |
| id | upm-95447 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T13:12:38Z |
| publishDate | 2021 |
| publisher | BioMed Central |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-954472023-01-04T09:01:40Z http://psasir.upm.edu.my/id/eprint/95447/ The global prevalence of osteoporosis in the world: a comprehensive systematic review and meta-analysis Salari, Nader Ghasemi, Hooman Mohammadi, Loghman Behzadi, Mohammad hasan Rabieenia, Elham Shohaimi, Shamarina Mohammadi, Masoud Background Osteoporosis affects all sections of society, including families with people affected by osteoporosis, government agencies and medical institutes in various fields. For example, it involves the patient and his/her family members, and government agencies in terms of the cost of treatment and medical care. Providing a comprehensive picture of the prevalence of osteoporosis globally is important for health policymakers to make appropriate decisions. Therefore, this study was conducted to investigate the prevalence of osteoporosis worldwide. Methods A systematic review and meta-analysis were conducted in accordance with the PRISMA criteria. The PubMed, Science Direct, Web of Science, Scopus, Magiran, and Google Scholar databases were searched with no lower time limit up till 26 August 2020. The heterogeneity of the studies was measured using the I2 test, and the publication bias was assessed by the Begg and Mazumdar’s test at the significance level of 0.1. Results After following the systematic review processes, 86 studies were selected for meta-analysis. The sample size of the study was 103,334,579 people in the age range of 15–105 years. Using meta-analysis, the prevalence of osteoporosis in the world was reported to be 18.3 (95% CI 16.2–20.7). Based on 70 studies and sample size of 800,457 women, and heterogenicity I2: 99.8, the prevalence of osteoporosis in women of the world was reported to be 23.1 (95% CI 19.8–26.9), while the prevalence of osteoporosis among men of the world was found to be 11.7 (95% CI 9.6–14.1 which was based on 40 studies and sample size of 453,964 men.). The highest prevalence of osteoporosis was reported in Africa with 39.5% (95% CI 22.3–59.7) and a sample size of 2989 people with the age range 18–95 years. Conclusion According to the medical, economic, and social burden of osteoporosis, providing a robust and comprehensive estimate of the prevalence of osteoporosis in the world can facilitate decisions in health system planning and policymaking, including an overview of the current and outlook for the future; provide the necessary facilities for the treatment of people with osteoporosis; reduce the severe risks that lead to death by preventing fractures; and, finally, monitor the overall state of osteoporosis in the world. This study is the first to report a structured review and meta-analysis of the prevalence of osteoporosis worldwide. BioMed Central 2021-10-17 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/95447/1/The%20global%20prevalence%20of%20osteoporosis%20in%20the%20world%20a%20comprehensive%20systematic%20review%20and%20meta-analysis.pdf Salari, Nader and Ghasemi, Hooman and Mohammadi, Loghman and Behzadi, Mohammad hasan and Rabieenia, Elham and Shohaimi, Shamarina and Mohammadi, Masoud (2021) The global prevalence of osteoporosis in the world: a comprehensive systematic review and meta-analysis. Journal of Orthopaedic Surgery and Research, 16 (609). pp. 1-20. ISSN 1749-799X https://josr-online.biomedcentral.com/articles/10.1186/s13018-021-02772-0 10.1186/s13018-021-02772-0 |
| spellingShingle | Salari, Nader Ghasemi, Hooman Mohammadi, Loghman Behzadi, Mohammad hasan Rabieenia, Elham Shohaimi, Shamarina Mohammadi, Masoud The global prevalence of osteoporosis in the world: a comprehensive systematic review and meta-analysis |
| title | The global prevalence of osteoporosis in the world: a comprehensive systematic review and meta-analysis |
| title_full | The global prevalence of osteoporosis in the world: a comprehensive systematic review and meta-analysis |
| title_fullStr | The global prevalence of osteoporosis in the world: a comprehensive systematic review and meta-analysis |
| title_full_unstemmed | The global prevalence of osteoporosis in the world: a comprehensive systematic review and meta-analysis |
| title_short | The global prevalence of osteoporosis in the world: a comprehensive systematic review and meta-analysis |
| title_sort | global prevalence of osteoporosis in the world: a comprehensive systematic review and meta-analysis |
| url | http://psasir.upm.edu.my/id/eprint/95447/ http://psasir.upm.edu.my/id/eprint/95447/ http://psasir.upm.edu.my/id/eprint/95447/ http://psasir.upm.edu.my/id/eprint/95447/1/The%20global%20prevalence%20of%20osteoporosis%20in%20the%20world%20a%20comprehensive%20systematic%20review%20and%20meta-analysis.pdf |