The characteristics and roles of antimicrobial peptides as potential treatment for antibiotic resistant pathogens: a review
The emergence of antibiotic-resistant bacteria has become a significant and ever-increasing threat to global public health, increasing both morbidity and mortality rates, and the financial burden on health services. Infection by drug-resistant bacteria is anticipated to contribute to the demise of a...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
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PeerJ
2021
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| Online Access: | http://psasir.upm.edu.my/id/eprint/95349/ |
| _version_ | 1848862135826776064 |
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| author | Zainal Baharin, Nurul Hana Khairil Mokhtar, Nur Fadhilah Mohd Desa, Mohd Nasir Gopalsamy, Banulata Mohd Zaki, Nor Nadiha Yuswan, Mohd Hafis Muthanna, Abdul Rahman Dzaraly, Nurul Diana Abbasiliasi, Sahar Mohd Hashim, Amalia Abdullah Sani, Muhamad Shirwan Mustafa, Shuhaimi |
| author_facet | Zainal Baharin, Nurul Hana Khairil Mokhtar, Nur Fadhilah Mohd Desa, Mohd Nasir Gopalsamy, Banulata Mohd Zaki, Nor Nadiha Yuswan, Mohd Hafis Muthanna, Abdul Rahman Dzaraly, Nurul Diana Abbasiliasi, Sahar Mohd Hashim, Amalia Abdullah Sani, Muhamad Shirwan Mustafa, Shuhaimi |
| author_sort | Zainal Baharin, Nurul Hana |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | The emergence of antibiotic-resistant bacteria has become a significant and ever-increasing threat to global public health, increasing both morbidity and mortality rates, and the financial burden on health services. Infection by drug-resistant bacteria is anticipated to contribute to the demise of almost 10 million people by the year 2050 unless a competent and effective response is devised to engage with this issue. The emergence and spread of resistance are commonly caused by the excessive or inappropriate use of antibiotics and substandard pharmaceuticals. It arises when pathogens adapt to different conditions and develop self-defence mechanisms. Currently, novel antimicrobial peptides (AMPs) have been reported to be the sole cure for some clinical cases of infectious diseases such as sepsis and skin infections, although these agents may, on occasion, require administration together with an adjunctive low-dose antibiotic. Although AMPs are a promising alternative form of anti-microbial therapy and easily applied in the medical sector, they still have limitations that should not be taken lightly. Hence, this review explores the characteristics, advantages and disadvantages of AMPs for their potential in treating antibiotic-resistant pathogens. |
| first_indexed | 2025-11-15T13:12:13Z |
| format | Article |
| id | upm-95349 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-15T13:12:13Z |
| publishDate | 2021 |
| publisher | PeerJ |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-953492023-02-02T08:57:20Z http://psasir.upm.edu.my/id/eprint/95349/ The characteristics and roles of antimicrobial peptides as potential treatment for antibiotic resistant pathogens: a review Zainal Baharin, Nurul Hana Khairil Mokhtar, Nur Fadhilah Mohd Desa, Mohd Nasir Gopalsamy, Banulata Mohd Zaki, Nor Nadiha Yuswan, Mohd Hafis Muthanna, Abdul Rahman Dzaraly, Nurul Diana Abbasiliasi, Sahar Mohd Hashim, Amalia Abdullah Sani, Muhamad Shirwan Mustafa, Shuhaimi The emergence of antibiotic-resistant bacteria has become a significant and ever-increasing threat to global public health, increasing both morbidity and mortality rates, and the financial burden on health services. Infection by drug-resistant bacteria is anticipated to contribute to the demise of almost 10 million people by the year 2050 unless a competent and effective response is devised to engage with this issue. The emergence and spread of resistance are commonly caused by the excessive or inappropriate use of antibiotics and substandard pharmaceuticals. It arises when pathogens adapt to different conditions and develop self-defence mechanisms. Currently, novel antimicrobial peptides (AMPs) have been reported to be the sole cure for some clinical cases of infectious diseases such as sepsis and skin infections, although these agents may, on occasion, require administration together with an adjunctive low-dose antibiotic. Although AMPs are a promising alternative form of anti-microbial therapy and easily applied in the medical sector, they still have limitations that should not be taken lightly. Hence, this review explores the characteristics, advantages and disadvantages of AMPs for their potential in treating antibiotic-resistant pathogens. PeerJ 2021-12-14 Article PeerReviewed Zainal Baharin, Nurul Hana and Khairil Mokhtar, Nur Fadhilah and Mohd Desa, Mohd Nasir and Gopalsamy, Banulata and Mohd Zaki, Nor Nadiha and Yuswan, Mohd Hafis and Muthanna, Abdul Rahman and Dzaraly, Nurul Diana and Abbasiliasi, Sahar and Mohd Hashim, Amalia and Abdullah Sani, Muhamad Shirwan and Mustafa, Shuhaimi (2021) The characteristics and roles of antimicrobial peptides as potential treatment for antibiotic resistant pathogens: a review. PeerJ. pp. 1-25. ISSN 2167-8359 https://peerj.com/articles/12193/ 10.7717/peerj.12193 |
| spellingShingle | Zainal Baharin, Nurul Hana Khairil Mokhtar, Nur Fadhilah Mohd Desa, Mohd Nasir Gopalsamy, Banulata Mohd Zaki, Nor Nadiha Yuswan, Mohd Hafis Muthanna, Abdul Rahman Dzaraly, Nurul Diana Abbasiliasi, Sahar Mohd Hashim, Amalia Abdullah Sani, Muhamad Shirwan Mustafa, Shuhaimi The characteristics and roles of antimicrobial peptides as potential treatment for antibiotic resistant pathogens: a review |
| title | The characteristics and roles of antimicrobial peptides as potential treatment for antibiotic resistant pathogens: a review |
| title_full | The characteristics and roles of antimicrobial peptides as potential treatment for antibiotic resistant pathogens: a review |
| title_fullStr | The characteristics and roles of antimicrobial peptides as potential treatment for antibiotic resistant pathogens: a review |
| title_full_unstemmed | The characteristics and roles of antimicrobial peptides as potential treatment for antibiotic resistant pathogens: a review |
| title_short | The characteristics and roles of antimicrobial peptides as potential treatment for antibiotic resistant pathogens: a review |
| title_sort | characteristics and roles of antimicrobial peptides as potential treatment for antibiotic resistant pathogens: a review |
| url | http://psasir.upm.edu.my/id/eprint/95349/ http://psasir.upm.edu.my/id/eprint/95349/ http://psasir.upm.edu.my/id/eprint/95349/ |