Synthesis of novel esters of mefenamic acid with pronounced anti-nociceptive effects and a proposed activity on GABA, opioid and glutamate receptors

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Synthesis of novel esters of mefenamic acid with pronounced anti-nociceptive effects and a proposed activity on GABA, opioid and glutamate receptors

Background: Mefenamic acid (MFA), a commonly prescribed non-steroidal anti-inflammatory drug (NSAID), possesses a greater risk of dose-related central nervous system (CNS) toxicity than other NSAIDs. In this study, α-tocopherol and α-tocopherol acetate were selected as prodrug moieties for MFA in an...

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Bibliographic Details
Main Authors:	Ayoub, Rami, Jarrar, Qais Bashir, Ali, Dalia, Moshawih, Said, Hakim, Muhammad Nazrul, Zakaria, Zainul Amiruddin
Format:	Article
Published:	Elsevier BV 2021
Online Access:	http://psasir.upm.edu.my/id/eprint/95272/

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