Synthesis of new 1,2-disubstituted benzimidazole analogs as potent inhibitors of Î-Glucuronidase and in silico study

QR Code

Synthesis of new 1,2-disubstituted benzimidazole analogs as potent inhibitors of Î-Glucuronidase and in silico study

New benzimidazole analogues (1–18) were synthesized and characterized through different spectroscopic techniques such as 1H NMR, 13C NMR and HREI-MS. All analogues were screened for β-glucuronidase inhibitory potential. All analogues showed varied degree of inhibitory potentials with IC50 values ran...

Full description

Bibliographic Details
Main Authors:	Muhammad Taha, Ahmad Khan, Aftab, Rahim, Fazal, Imran, Syahrul, Mohammed Salahuddin, Uddin, Nizam, Mohammed Khan, Khalid, Ali Shah, Syed Adnan, Zafar, Ameeduzzafar, Zakaria, Zainul Amiruddin
Format:	Article
Published:	Elsevier B.V. 2021
Online Access:	http://psasir.upm.edu.my/id/eprint/95271/

Similar Items

Synthesis of chromen-4-one-oxadiazole substituted analogs as potent β-glucuronidase inhibitors
by: Taha, Muhammad, et al.
Published: (2019)

Synthesis of chromen-4-one-oxadiazole substituted analogs as potent β-glucuronidase inhibitors
by: Taha, Muhammad, et al.
Published: (2019)

Synthesis And Biological Activity Of Benzimidazole Analogs As Sirtuin Enzyme Inhibitors
by: Yeong, Keng Yoon
Published: (2016)

In silico designing of thermostabe β-Glucuronidase (GUS)
by: Noorbatcha, Ibrahim Ali, et al.
Published: (2010)

2-Benzoyl-6-benzylidenecyclohexanone analogs as potent dual inhibitors of acetylcholinesterase and butyrylcholinesterase
by: Sze, Wei Leong, et al.
Published: (2016)

Synthesis of new isoquinoline-base-oxadiazole derivatives as potent inhibitors of thymidine phosphorylase and molecular docking study
by: Zaman, Khalid, et al.
Published: (2019)

Design and synthesis of benzimidazole-based Rho kinase inhibitors for the treatment of glaucoma
by: Abbhi, V., et al.
Published: (2017)

In-silico design of curcumin analogs as potential inhibitors of dengue virus NS2B/NS3 protease
by: Roney, Miah, et al.
Published: (2023)

Molecular dynamics studies of human β-Glucuronidase
by: Noorbatcha, Ibrahim Ali, et al.
Published: (2010)

Molecular dynamics studies of human β-glucuronidase
by: Noorbatcha, Ibrahim Ali, et al.
Published: (2009)

In silico study of the ErbB4 interactions with curcumin analogs
by: Azman, Putri Arsyadian, et al.
Published: (2015)

Mechanism Of Action Of A Benzimidazole Sirtuin Inhibitor, Bzd9l1, In Colorectal Cancer
by: Tan, Yi Jer
Published: (2022)

Homology Modeling Of β-Glucuronidases From E. Coli and T. Maritima
by: Noorbatcha, Ibrahim Ali, et al.
Published: (2009)

Virtual screening-based identification of Potent DENV-3 RdRp protease inhibitors via in-house usnic acid derivative database
by: Roney, Miah, et al.
Published: (2021)

Synthesis, Characterization And Anti-Proliferation Study Of Some Benzimidazole Derivatives
by: al-Douh, Mohammed Hadi Saeed
Published: (2010)

The Use of Peptide-Membrane Interactions in the Design of Selective and Potent Sodium Channel Inhibitors
by: Schroeder, C., et al.
Published: (2018)

Design and Synthesis of Chalcone Derivatives as Potent Tyrosinase Inhibitors and Their Structural Activity Relationship
by: Akhtar, Muhammad Nadeem, et al.
Published: (2015)

Hierarchical And Fragment Based Virtual Screening Approaches In The Discovery Of Potent Acetylcholinesterase Inhibitor
by: Muhammad, Erma Fatiha
Published: (2022)

Benzimidazole derivatives as potential dual inhibitors for poly (adp-ribose) polymerase-1 and dihydroorotate dehydrogenase / Iskandar Abdullah
by: Iskandar, Abdullah
Published: (2015)

In silico study of carvone derivatives as potential neuraminidase inhibitors
by: Jusoh, Noorakmar, et al.
Published: (2018)

Synthesis, characterization and anti-proliferation study of some Benzimidazole derivatives
by: Al-Douh, Mohammed H., et al.
Published: (2011)

Novel phospholipase A2 inhibitors from python serum are potent peptide antibiotics
by: Samy, R., et al.
Published: (2015)

Consistent assignment of the vibrations of symmetric and asymmetric ortho-disubstituted benzenes
by: Tuttle, William D., et al.
Published: (2017)

Consistent assignment of the vibrations of symmetric and asymmetric meta-disubstituted benzenes
by: Kemp, David J., et al.
Published: (2018)

Vibration and torsion-facilitated interactions in para- and meta-disubstituted benzenes
by: Kemp, David J.
Published: (2020)

In vitro and in silico evaluations of diarylpentanoid series as a-glucosidase inhibitor
by: Leong, Sze Wei, et al.
Published: (2018)

In silico identification of PPARγ agonists from diffractaic acid analogs in prostate cancer: a comprehensive computational approach
by: Roney, Miah, et al.
Published: (2025)

Development of potent, selective SRPK1 inhibitors as potential topical therapeutics for neovascular eye disease
by: Batson, Jennifer, et al.
Published: (2017)

Therapeutic potential inhibitor for dipeptidyl peptidase IV in diabetic type 2: In silico approaches
by: Roney, Miah, et al.
Published: (2025)

Design and Synthesis of New Barbituric- and Thiobarbituric Acid Derivatives as Potent Urease Inhibitors: Structure Activity Relationship and Molecular Modeling Studies
by: Rauf, Abdul, et al.
Published: (2015)

Bioprocessing of recombinant E.Coli producing Glucuronidase Enzymes
by: Mel, Maizirwan
Published: (2012)

Insights from in silico exploration of major curcumin analogs targeting human dipeptidyl peptidase IV
by: Roney, Miah, et al.
Published: (2024)

Enantioselective synthesis of 6,6-disubstituted pentafulvenes containing a chiral pendant hydroxy group
by: Nouch, Ryan, et al.
Published: (2017)

Consistent assignment of the vibrations of symmetric and asymmetric para-disubstituted benzene molecules
by: Andrejeva, Anna, et al.
Published: (2016)

In silico analysis for discovery of dengue virus inhibitor from natural compounds
by: Roney, Miah, et al.
Published: (2022)

Symmetric molecules with 1,4-triazole moieties as potent inhibitors of tumour-associated lactate dehydrogenase-A
by: Altamimi, Abdul Malek S., et al.
Published: (2018)

Molecular profiling and combinatorial activity of CCT068127: a potent CDK2 and CDK9 inhibitor
by: Whittaker, Steven R., et al.
Published: (2018)

Conventional Organic Solvents And Ionic Liquid Mediated Synthesis Of New Azomethine Compounds As Potent Cholinesterase Inhibitors
by: M. Abd Razik, Basma
Published: (2016)

Molecular docking analysis on the designed benzimidazole derivatives as EGFR inhibitors: comparison between EGFR wild-type (EGFRWT) and T790M mutant
by: Nurul Awani Syazzira Jalil,, et al.
Published: (2023)

Batch process modelling and economic evaluation of glucuronidase enzyme production
by: Kamuri, M Firdaus, et al.
Published: (2012)