Survey on serum protein electrophoresis and recommendations for standardised reporting
Introduction: Serum protein electrophoresis (SPE) is a well-established laboratory technique. However, reporting of results varies considerably between laboratories. The variation in reporting can cause confusion to the clinician with a potential of adversely impacting patient care. The purpose of t...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Published: |
Malaysian Society of Pathologists
2021
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/95222/ |
| _version_ | 1848862101848719360 |
|---|---|
| author | Sthaneshwar, Pavai C Thambiah, Subashini Mat Salleh, Mohd Jamsani Nasuruddin, Dian Nasriana Ahmad Zabidi, Nurul Faatima Mohammed Jelani, Aniza Mohd Ismail, Aletza Lai, Leslie Charles Gan, Gin Gin |
| author_facet | Sthaneshwar, Pavai C Thambiah, Subashini Mat Salleh, Mohd Jamsani Nasuruddin, Dian Nasriana Ahmad Zabidi, Nurul Faatima Mohammed Jelani, Aniza Mohd Ismail, Aletza Lai, Leslie Charles Gan, Gin Gin |
| author_sort | Sthaneshwar, Pavai |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Introduction: Serum protein electrophoresis (SPE) is a well-established laboratory technique. However, reporting of results varies considerably between laboratories. The variation in reporting can cause confusion to the clinician with a potential of adversely impacting patient care. The purpose of the survey was to find out the variation in reporting and to prepare recommendations to the Malaysian laboratories based on the survey to reduce both the variation in reporting between laboratories and the risk of misinterpretation of reports. Materials and Methods: To determine the extent of variation in reporting of protein electrophoresis results questionnaires were distributed to the pathologists of various laboratories in Malaysia regarding the method, quantification of paraprotein concentrations and immunoglobulin assays, and information regarding current laboratory electrophoresis practices. Results: Variation was found in the following reporting practices: (a) screening protocol; (b) reporting of serum albumin; (c) numerical reporting of protein fractions and paraprotein; (d) co-migration of a paraprotein with a normal serum protein; (e) reporting of multiple paraprotein bands (f) appearance of small abnormal band and oligoclonal bands and (g) communication about of interferences. Conclusion: The pathologists of the country made recommendations on the reporting of protein electrophoresis. Harmonised reporting will reduce inconsistency, variation in reporting, improve the quality of the report and most importantly improve patient care. |
| first_indexed | 2025-11-15T13:11:41Z |
| format | Article |
| id | upm-95222 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-15T13:11:41Z |
| publishDate | 2021 |
| publisher | Malaysian Society of Pathologists |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-952222023-05-18T02:35:07Z http://psasir.upm.edu.my/id/eprint/95222/ Survey on serum protein electrophoresis and recommendations for standardised reporting Sthaneshwar, Pavai C Thambiah, Subashini Mat Salleh, Mohd Jamsani Nasuruddin, Dian Nasriana Ahmad Zabidi, Nurul Faatima Mohammed Jelani, Aniza Mohd Ismail, Aletza Lai, Leslie Charles Gan, Gin Gin Introduction: Serum protein electrophoresis (SPE) is a well-established laboratory technique. However, reporting of results varies considerably between laboratories. The variation in reporting can cause confusion to the clinician with a potential of adversely impacting patient care. The purpose of the survey was to find out the variation in reporting and to prepare recommendations to the Malaysian laboratories based on the survey to reduce both the variation in reporting between laboratories and the risk of misinterpretation of reports. Materials and Methods: To determine the extent of variation in reporting of protein electrophoresis results questionnaires were distributed to the pathologists of various laboratories in Malaysia regarding the method, quantification of paraprotein concentrations and immunoglobulin assays, and information regarding current laboratory electrophoresis practices. Results: Variation was found in the following reporting practices: (a) screening protocol; (b) reporting of serum albumin; (c) numerical reporting of protein fractions and paraprotein; (d) co-migration of a paraprotein with a normal serum protein; (e) reporting of multiple paraprotein bands (f) appearance of small abnormal band and oligoclonal bands and (g) communication about of interferences. Conclusion: The pathologists of the country made recommendations on the reporting of protein electrophoresis. Harmonised reporting will reduce inconsistency, variation in reporting, improve the quality of the report and most importantly improve patient care. Malaysian Society of Pathologists 2021 Article PeerReviewed Sthaneshwar, Pavai and C Thambiah, Subashini and Mat Salleh, Mohd Jamsani and Nasuruddin, Dian Nasriana and Ahmad Zabidi, Nurul Faatima and Mohammed Jelani, Aniza and Mohd Ismail, Aletza and Lai, Leslie Charles and Gan, Gin Gin (2021) Survey on serum protein electrophoresis and recommendations for standardised reporting. Malaysian Journal of Pathology, 43 (2). 281 - 290. ISSN 01268635 http://www.mjpath.org.my/2021/v43n2/index.php |
| spellingShingle | Sthaneshwar, Pavai C Thambiah, Subashini Mat Salleh, Mohd Jamsani Nasuruddin, Dian Nasriana Ahmad Zabidi, Nurul Faatima Mohammed Jelani, Aniza Mohd Ismail, Aletza Lai, Leslie Charles Gan, Gin Gin Survey on serum protein electrophoresis and recommendations for standardised reporting |
| title | Survey on serum protein electrophoresis and recommendations for standardised reporting |
| title_full | Survey on serum protein electrophoresis and recommendations for standardised reporting |
| title_fullStr | Survey on serum protein electrophoresis and recommendations for standardised reporting |
| title_full_unstemmed | Survey on serum protein electrophoresis and recommendations for standardised reporting |
| title_short | Survey on serum protein electrophoresis and recommendations for standardised reporting |
| title_sort | survey on serum protein electrophoresis and recommendations for standardised reporting |
| url | http://psasir.upm.edu.my/id/eprint/95222/ http://psasir.upm.edu.my/id/eprint/95222/ |