Characterization of the inclusion complex of zerumbone with hydroxypropyl--cyclodextrin

In this paper we investigated the inclusion complexation between zerumbone (ZER) and hydroxylpropyl- -cyclodextrin (HPCD) at four different temperatures: 293–318 ◦K. The thermodynamic parameters (H, S and G) for the formation of the complex were obtained from the van’t Hoff equation. The complex...

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Main Authors:	E. M. Eid, Eltayeb, Abdul, Ahmad Bustamam, O. Suliman, Fakhr Eldin, Sukari, Mohd Aspollah, Abdullah, Rasedee, S. Fatah, Safa
Format:	Article
Language:	English English
Published:	2010 Elsevier Ltd. All rights reserved 2011
Online Access:	http://psasir.upm.edu.my/id/eprint/9460/ http://psasir.upm.edu.my/id/eprint/9460/1/Characterization%20of%20the%20inclusion%20complex%20of%20zerumbone%20with%20hydroxypropyl.pdf

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author	E. M. Eid, Eltayeb Abdul, Ahmad Bustamam O. Suliman, Fakhr Eldin Sukari, Mohd Aspollah Abdullah, Rasedee S. Fatah, Safa
author_facet	E. M. Eid, Eltayeb Abdul, Ahmad Bustamam O. Suliman, Fakhr Eldin Sukari, Mohd Aspollah Abdullah, Rasedee S. Fatah, Safa
author_sort	E. M. Eid, Eltayeb
building	UPM Institutional Repository
collection	Online Access
description	In this paper we investigated the inclusion complexation between zerumbone (ZER) and hydroxylpropyl- -cyclodextrin (HPCD) at four different temperatures: 293–318 ◦K. The thermodynamic parameters (H, S and G) for the formation of the complex were obtained from the van’t Hoff equation. The complex with HPCD was characterized by differential scanning calorimetry (DSC), X-ray diffractometry (XRD), Fourier transform infrared spectroscopy (FT-IR), and molecular modeling using PM6. The solubility of ZER was enhanced >30 fold after complexation. Calculations show that ZER penetrates completely into the cavity of HPCD. The complex retained its cytotoxic activity as shown by in vitro cell survival assay on human cervical cancer (Hela), breast cancer (MCF7 and MDA-MB 231) and human leukemic (CEMss) cell lines. HPCD is, therefore, a suitable encapsular capable of forming thermodynamically stable complex with ZER for save delivery of the compound as an anticancer drug in the future.
first_indexed	2025-11-15T07:38:41Z
format	Article
id	upm-9460
institution	Universiti Putra Malaysia
institution_category	Local University
language	English English
last_indexed	2025-11-15T07:38:41Z
publishDate	2011
publisher	2010 Elsevier Ltd. All rights reserved
recordtype	eprints
repository_type	Digital Repository
spelling	upm-94602015-09-09T04:39:04Z http://psasir.upm.edu.my/id/eprint/9460/ Characterization of the inclusion complex of zerumbone with hydroxypropyl--cyclodextrin E. M. Eid, Eltayeb Abdul, Ahmad Bustamam O. Suliman, Fakhr Eldin Sukari, Mohd Aspollah Abdullah, Rasedee S. Fatah, Safa In this paper we investigated the inclusion complexation between zerumbone (ZER) and hydroxylpropyl- -cyclodextrin (HPCD) at four different temperatures: 293–318 ◦K. The thermodynamic parameters (H, S and G) for the formation of the complex were obtained from the van’t Hoff equation. The complex with HPCD was characterized by differential scanning calorimetry (DSC), X-ray diffractometry (XRD), Fourier transform infrared spectroscopy (FT-IR), and molecular modeling using PM6. The solubility of ZER was enhanced >30 fold after complexation. Calculations show that ZER penetrates completely into the cavity of HPCD. The complex retained its cytotoxic activity as shown by in vitro cell survival assay on human cervical cancer (Hela), breast cancer (MCF7 and MDA-MB 231) and human leukemic (CEMss) cell lines. HPCD is, therefore, a suitable encapsular capable of forming thermodynamically stable complex with ZER for save delivery of the compound as an anticancer drug in the future. 2010 Elsevier Ltd. All rights reserved 2011-02-01 Article PeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/9460/1/Characterization%20of%20the%20inclusion%20complex%20of%20zerumbone%20with%20hydroxypropyl.pdf E. M. Eid, Eltayeb and Abdul, Ahmad Bustamam and O. Suliman, Fakhr Eldin and Sukari, Mohd Aspollah and Abdullah, Rasedee and S. Fatah, Safa (2011) Characterization of the inclusion complex of zerumbone with hydroxypropyl--cyclodextrin. Carbohydrate Polymers, 83 (4). pp. 1707-1714. ISSN 0144-8617 http://dx.doi.org/10.1016/j.carbpol.2010.10.033 10.1016/j.carbpol.2010.10.033 English
spellingShingle	E. M. Eid, Eltayeb Abdul, Ahmad Bustamam O. Suliman, Fakhr Eldin Sukari, Mohd Aspollah Abdullah, Rasedee S. Fatah, Safa Characterization of the inclusion complex of zerumbone with hydroxypropyl--cyclodextrin
title	Characterization of the inclusion complex of zerumbone with hydroxypropyl--cyclodextrin
title_full	Characterization of the inclusion complex of zerumbone with hydroxypropyl--cyclodextrin
title_fullStr	Characterization of the inclusion complex of zerumbone with hydroxypropyl--cyclodextrin
title_full_unstemmed	Characterization of the inclusion complex of zerumbone with hydroxypropyl--cyclodextrin
title_short	Characterization of the inclusion complex of zerumbone with hydroxypropyl--cyclodextrin
title_sort	characterization of the inclusion complex of zerumbone with hydroxypropyl--cyclodextrin
url	http://psasir.upm.edu.my/id/eprint/9460/ http://psasir.upm.edu.my/id/eprint/9460/ http://psasir.upm.edu.my/id/eprint/9460/ http://psasir.upm.edu.my/id/eprint/9460/1/Characterization%20of%20the%20inclusion%20complex%20of%20zerumbone%20with%20hydroxypropyl.pdf

Characterization of the inclusion complex of zerumbone with hydroxypropyl--cyclodextrin

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