Optimization of silver nanoparticles production using Aspergillus niger and study of antimicrobial activity
Silver nanoparticles have attracted high attention worldwide for their various applications. The physiochemical parameters such as temperature, media, mixing ratio affect the rate of synthesis of silver nanoparticles and their yield. Thus, optimization of these physiochemical parameters is needed to...
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J K Welfare & Pharmascope Foundation
2021
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| Online Access: | http://psasir.upm.edu.my/id/eprint/94463/ |
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| author | Selvakumaran, Suguna Marimuthu, Kayathri Poopalan, Thiruvany Tamil Selvan, Kalaiyarasi Khairuddin, Nozieana |
| author_facet | Selvakumaran, Suguna Marimuthu, Kayathri Poopalan, Thiruvany Tamil Selvan, Kalaiyarasi Khairuddin, Nozieana |
| author_sort | Selvakumaran, Suguna |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Silver nanoparticles have attracted high attention worldwide for their various applications. The physiochemical parameters such as temperature, media, mixing ratio affect the rate of synthesis of silver nanoparticles and their yield. Thus, optimization of these physiochemical parameters is needed to enhance the production of silver nanoparticles. In this study, silver nanoparticles were synthesized using Aspergillus niger culture supernatant. The produced silver nanoparticles were characterized using UV-visible Spectrophotometer at 200nm to 700 nm, which had a peak at 450 nm, indicates the formation of silver nanoparticles. It was found that Sabouraud Dextrose Broth(SDB)as optimum media, 40 ml of supernatant and 10 ml of silver nitrate as optimum mixing ratio and 65◦C as optimum temperature to produce silver nanoparticles. The optimized silver nanoparticles were subjected to antimicrobial activity, and itwasfoundthatitishighlyeffectivetowardsgram-negativebacteriathangram-positive bacteria where the zone of inhibition for Escherichia coli was 7±2.7mm and 5.3±2.1 mm for Staphylococcus aureus. |
| first_indexed | 2025-11-15T13:10:08Z |
| format | Article |
| id | upm-94463 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-15T13:10:08Z |
| publishDate | 2021 |
| publisher | J K Welfare & Pharmascope Foundation |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-944632023-02-07T03:47:11Z http://psasir.upm.edu.my/id/eprint/94463/ Optimization of silver nanoparticles production using Aspergillus niger and study of antimicrobial activity Selvakumaran, Suguna Marimuthu, Kayathri Poopalan, Thiruvany Tamil Selvan, Kalaiyarasi Khairuddin, Nozieana Silver nanoparticles have attracted high attention worldwide for their various applications. The physiochemical parameters such as temperature, media, mixing ratio affect the rate of synthesis of silver nanoparticles and their yield. Thus, optimization of these physiochemical parameters is needed to enhance the production of silver nanoparticles. In this study, silver nanoparticles were synthesized using Aspergillus niger culture supernatant. The produced silver nanoparticles were characterized using UV-visible Spectrophotometer at 200nm to 700 nm, which had a peak at 450 nm, indicates the formation of silver nanoparticles. It was found that Sabouraud Dextrose Broth(SDB)as optimum media, 40 ml of supernatant and 10 ml of silver nitrate as optimum mixing ratio and 65◦C as optimum temperature to produce silver nanoparticles. The optimized silver nanoparticles were subjected to antimicrobial activity, and itwasfoundthatitishighlyeffectivetowardsgram-negativebacteriathangram-positive bacteria where the zone of inhibition for Escherichia coli was 7±2.7mm and 5.3±2.1 mm for Staphylococcus aureus. J K Welfare & Pharmascope Foundation 2021-10-16 Article PeerReviewed Selvakumaran, Suguna and Marimuthu, Kayathri and Poopalan, Thiruvany and Tamil Selvan, Kalaiyarasi and Khairuddin, Nozieana (2021) Optimization of silver nanoparticles production using Aspergillus niger and study of antimicrobial activity. International Journal of Research in Pharmaceutical Sciences, 12 (4). 2383 - 2388. ISSN 0975-7538 https://ijrps.com/index.php/home/article/view/388 10.26452/ijrps.v12i4.4872 |
| spellingShingle | Selvakumaran, Suguna Marimuthu, Kayathri Poopalan, Thiruvany Tamil Selvan, Kalaiyarasi Khairuddin, Nozieana Optimization of silver nanoparticles production using Aspergillus niger and study of antimicrobial activity |
| title | Optimization of silver nanoparticles production using Aspergillus niger and study of antimicrobial activity |
| title_full | Optimization of silver nanoparticles production using Aspergillus niger and study of antimicrobial activity |
| title_fullStr | Optimization of silver nanoparticles production using Aspergillus niger and study of antimicrobial activity |
| title_full_unstemmed | Optimization of silver nanoparticles production using Aspergillus niger and study of antimicrobial activity |
| title_short | Optimization of silver nanoparticles production using Aspergillus niger and study of antimicrobial activity |
| title_sort | optimization of silver nanoparticles production using aspergillus niger and study of antimicrobial activity |
| url | http://psasir.upm.edu.my/id/eprint/94463/ http://psasir.upm.edu.my/id/eprint/94463/ http://psasir.upm.edu.my/id/eprint/94463/ |