Optimal 18F-fluorination conditions for the high radiochemical yield of [18F]AlF-NOTA-NHS complexes
18F-fluorination using aluminum-fluoride ([18F]AlF) chelate technique has been reported to give a low-to-moderate radiochemical yield, between 5 and 20%. Therefore, the work described here outlines the optimum 18F-fluorination condition for the formation of [18F]AlF2+ and [18F]AlF-NOTA-NHS complex w...
| Main Authors: | , , |
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| Format: | Article |
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De Gruyter
2021
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| Online Access: | http://psasir.upm.edu.my/id/eprint/94441/ |
| _version_ | 1848861998232633344 |
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| author | Hassan, Hishar Othman, Muhammad Faiz Abdul Razak, Hairil Rashmizal |
| author_facet | Hassan, Hishar Othman, Muhammad Faiz Abdul Razak, Hairil Rashmizal |
| author_sort | Hassan, Hishar |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | 18F-fluorination using aluminum-fluoride ([18F]AlF) chelate technique has been reported to give a low-to-moderate radiochemical yield, between 5 and 20%. Therefore, the work described here outlines the optimum 18F-fluorination condition for the formation of [18F]AlF2+ and [18F]AlF-NOTA-NHS complex with the radiochemical yield (RCY) and purity (RCP) of more than 90% as a prerequisite step before proceeding with the radiopharmaceutical preparation using the [18F]AlF-bifunctional chelator technique. As well as being simple, the suggested method is practical and relevant for beginners interested in 18F-fluorination with [18F]AlF-chelate complex technique or also for a researcher who aims to proceed on an extensive scale. |
| first_indexed | 2025-11-15T13:10:02Z |
| format | Article |
| id | upm-94441 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-15T13:10:02Z |
| publishDate | 2021 |
| publisher | De Gruyter |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-944412023-04-04T01:57:39Z http://psasir.upm.edu.my/id/eprint/94441/ Optimal 18F-fluorination conditions for the high radiochemical yield of [18F]AlF-NOTA-NHS complexes Hassan, Hishar Othman, Muhammad Faiz Abdul Razak, Hairil Rashmizal 18F-fluorination using aluminum-fluoride ([18F]AlF) chelate technique has been reported to give a low-to-moderate radiochemical yield, between 5 and 20%. Therefore, the work described here outlines the optimum 18F-fluorination condition for the formation of [18F]AlF2+ and [18F]AlF-NOTA-NHS complex with the radiochemical yield (RCY) and purity (RCP) of more than 90% as a prerequisite step before proceeding with the radiopharmaceutical preparation using the [18F]AlF-bifunctional chelator technique. As well as being simple, the suggested method is practical and relevant for beginners interested in 18F-fluorination with [18F]AlF-chelate complex technique or also for a researcher who aims to proceed on an extensive scale. De Gruyter 2021-05-13 Article PeerReviewed Hassan, Hishar and Othman, Muhammad Faiz and Abdul Razak, Hairil Rashmizal (2021) Optimal 18F-fluorination conditions for the high radiochemical yield of [18F]AlF-NOTA-NHS complexes. Radiochimica Acta, 109 (7). 567 - 574. ISSN 0033-8230; ESSN: 2193-3405 https://www.degruyter.com/document/doi/10.1515/ract-2021-1024/html 10.1515/ract-2021-1024 |
| spellingShingle | Hassan, Hishar Othman, Muhammad Faiz Abdul Razak, Hairil Rashmizal Optimal 18F-fluorination conditions for the high radiochemical yield of [18F]AlF-NOTA-NHS complexes |
| title | Optimal 18F-fluorination conditions for the high radiochemical yield of [18F]AlF-NOTA-NHS complexes |
| title_full | Optimal 18F-fluorination conditions for the high radiochemical yield of [18F]AlF-NOTA-NHS complexes |
| title_fullStr | Optimal 18F-fluorination conditions for the high radiochemical yield of [18F]AlF-NOTA-NHS complexes |
| title_full_unstemmed | Optimal 18F-fluorination conditions for the high radiochemical yield of [18F]AlF-NOTA-NHS complexes |
| title_short | Optimal 18F-fluorination conditions for the high radiochemical yield of [18F]AlF-NOTA-NHS complexes |
| title_sort | optimal 18f-fluorination conditions for the high radiochemical yield of [18f]alf-nota-nhs complexes |
| url | http://psasir.upm.edu.my/id/eprint/94441/ http://psasir.upm.edu.my/id/eprint/94441/ http://psasir.upm.edu.my/id/eprint/94441/ |