Non-deletional alpha thalassaemia: a review of emerging therapy

QR Code

Non-deletional alpha thalassaemia: a review of emerging therapy

More than seventy non-deletional α-thalassaemia mutations have been reported and they usually exhibit more severe clinical presentations compared to their deletional counterparts. Conventional treatment aims to manage the symptoms of the disease through red blood cell transfusion, but this has its...

Full description

Bibliographic Details
Main Authors:	Khairil Wahidin, Nurfhaezah, Lai, Mei I.
Format:	Article
Language:	English
Published:	Universiti Putra Malaysia 2021
Online Access:	http://psasir.upm.edu.my/id/eprint/94367/ http://psasir.upm.edu.my/id/eprint/94367/1/Non-Deletional%20Alpha%20Thalassaemia_A%20Review%20of%20Emerging%20Therapy.pdf

Similar Items

Haematological parameter evaluation in different types of deletional alpha thalassaemia and in coinheritance of deletional alpha thalassaemia and beta thalassaemia in Hospital Universiti Sains Malaysia
by: Arifin, Samilawati Mohd
Published: (2018)

Haematology, genetics and molecular epidemiology of deletional alpha thalassaemia in Malaysia
by: Mohd Yacob, Aliza
Published: (2011)

HbA2 levels in β-thalassaemia carriers with the Filipino β0-deletion: are the levels higher than what is found with non-deletional forms of β0-thalassaemia?
by: George, Elizabeth, et al.
Published: (2013)

Alpha thalassaemia due to non-deletional mutations on the -3.7 alpha globin fusion gene: Laboratory diagnosis and clinical importance
by: Chow, A., et al.
Published: (2013)

Detection on common deletional alpha thalassaemia in pregnant women by polymerase chain reaction techniques
by: Fathma Abdullah, Nurul Ain
Published: (2015)

Concurrent inheritance of deletional a-thalassaemia in Malays with HbE trait
by: Teh, Lai Kuan, et al.
Published: (2009)

Elucidating the possible mechanism of renal dysfunction in alpha thalassaemia: a review
by: Nor Aziz Hashim, Nurul Aiman Farhana, et al.
Published: (2020)

Haplotype analysis of β-Thalassaemia major and carriers with Filipino β°-deletion in Sabah, Malaysia
by: Teh, Lai Kuan, et al.
Published: (2018)

Screening of Alpha-Thalassaemia 1 in Beta-Thalassaemia Carriers
by: Chong, Yi Min
Published: (2005)

Optimal mean corpuscular haemoglobin (MCH) cut-off value for differentiating alpha plus and alpha zero thalassaemia in thalassaemia screening
by: Idris, Faridah, et al.
Published: (2020)

Haemoglobin Adana in alpha thalassaemia intermedia in the Malaysian population
by: Lee, Tze Yan
Published: (2017)

Detection on common deletional alpha-thallasaemia in pregnant lady by polymerase chain reaction
by: Rosline, Hassan
Published: (2012)

Usefulness of red blood cell size factor (RSf) in screening genetic variants of alpha thalassaemia thalassaemia trait regardless of iron status
by: Idris, Nur Juliana, et al.
Published: (2018)

Association of Alpha Haemoglobin Stabilizing Protein in HbE/ Beta-Thalassaemia Patients in Malaysia
by: Lim, Wai Feng
Published: (2011)

Coinheritance of haemoglobin e trait with alpha thalassaemia among Malay students in national thalassaemia screening programme in Hospital Sultanah Nur Zahirah Kuala Terengganu
by: Somasundram, Suguna, et al.
Published: (2021)

A rare case of alpha-thalassaemia intermedia in a Malay patient double heterozygous for α+ –thalassaemia and a mutation in α1 globin gene CD59 (GGC → GAC)
by: George, Elizabeth, et al.
Published: (2009)

Molecular characterisation of alpha-thalassaemia in patients investigated for hypochromic microcytic indices in Hospital Universiti Sains Malaysia
by: Vijian, Divashini
Published: (2023)

Effects of transfusion and splenectomy on globin chain expression in NTDT HbE/β-thalassaemia
by: Lim, Wai Feng, et al.
Published: (2021)

The novel role of the B-cell lymphoma/leukemia 11A (BCL11A) gene in β-thalassaemia treatment
by: Lai, Mei I, et al.
Published: (2023)

Association of insertion/deletion polymorphism of alpha-adrenoceptor gene in essential hypertension with or without type 2 diabetes mellitus in Malaysian subjects.
by: Vasudevan, Ramachandran, et al.
Published: (2008)

Rapid detection of α-thalassaemia variants using droplet digital PCR
by: Lee, Tze Yan, et al.
Published: (2016)

Hb lepore/β0-thalassaemia with α+-thalassaemia interactions, a potential diagnostic pitfall
by: Hafiza, Alauddin, et al.
Published: (2015)

Haematologic profile of haemoglobin constant spring and its co-inheritance with alpha and beta thalassaemia among form four students in Negeri Sembilan
by: Nahanthiran, Subithira, et al.
Published: (2022)

Molecular characterisation of beta thalassaemia in patients from Sabah, Malaysia
by: Teh, Lai Kuan
Published: (2014)

Screening for intermediate and severe forms of thalassaemia in discarded red blood cells: optimization and feasibility
by: George, Elizabeth, et al.
Published: (2011)

MOH should delete old informations
by: Tamil Malar
Published: (2022)

CCR5 polymorphisms and its relationship with HIV susceptibility, viral load and CD4 count in early antiretroviral therapy among HIV patients in Selangor and Terengganu
by: Mohamad Isa, Irma Izani, et al.
Published: (2023)

Screening of thalassaemia carriers and its limitations
by: George, Elizabeth
Published: (2014)

An assessment of three noncommercial DNA extraction methods from dried blood spots for beta-thalassaemia mutation identification.
by: Kartipan, S. N., et al.
Published: (2011)

The phenotype associated with a large deletion on MECP2
by: Bebbington, A., et al.
Published: (2012)

Development Of Gene Deleted Recombinant Pseudorabies Virus
by: Alauddin, Zeenathul Nazariah
Published: (2004)

An evolutionary algorithm for graph planarisation by vertex deletion
by: Pinheiro, Rodrigo Lankaites, et al.
Published: (2014)

Prevalence of beta thalassaemia/beta haemoglobin variant among thalassaemia screening in Hospital Tengku Ampuan Rahimah (HTAR), Klang
by: Mohyee, Norlyiyana
Published: (2020)

Clinico-haematological profiling of transfusion dependent and non transfucion dependent beta thalassaemia syndrome in Kedah
by: Azizi, Fahmaa
Published: (2020)

Thalassaemia: A study on the perception of patients and family members
by: Jantan, Abdul Wahab, et al.
Published: (2011)

Thalassaemia : a study on the perception of patients and family members
by: Jantan, Abdul Wahab, et al.
Published: (2011)

Thalassaemia: a study on the perception of patients and family members
by: Jantan, Abdul Wahab, et al.
Published: (2011)

Screening for thalassaemia in pregnant women: a laboratory perspective
by: George, Elizabeth, et al.
Published: (2005)

Transfusion transmitted malaria in a thalassaemia major patient
by: Anuar, Nur Aliaa, et al.
Published: (2020)

A study of thalassaemia among blood donors in HUSM
by: Adam, Nor Atifah bt. Mohd
Published: (2004)