| Summary: | : Background: Evidence is growing that a high-acid diet might accelerate the rate of bone
loss, and gene polymorphisms such as Interleukin 6 (IL6) -174G/C and -572G/C are related to
bone deterioration. However, no study of the interaction between diet and IL6 polymorphisms
has been conducted among Asians. Thus, the objective of this study was to determine whether
IL6 gene polymorphisms modified the association between dietary acidity and the rate of bone
resorption. Methods: This cross-sectional study recruited 203 postmenopausal women (age ranged
from 51 to 85 years old) in community settings. The dietary intakes of the participants were assessed
using a validated interviewer-administered semi-quantitative food frequency questionnaire (FFQ),
while dietary acid load (DAL) was estimated using net endogenous acid production (NEAP). Agena®
MassARRAY genotyping analysis and serum collagen type 1 cross-linked C-telopeptide (CTX1) were
used to identify the IL6 genotype and as a bone resorption marker, respectively. The interactions
between diet and single-nucleotide polymorphisms (SNPs) were assessed using linear regressions.
Results: A total of 203 healthy postmenopausal women aged between 51 and 85 years participated in
this study. The mean BMI of the participants was 24.3 kg/m2
. In IL6 -174 G/C, all the participants
carried the GG genotype, while the C allele was absent. Approximately 40% of the participants had a
high dietary acid load. Dietary acid load (B = 0.15, p = 0.031) and the IL6 -572 CC genotype group
(B = 0.14, p = 0.044) were positively associated with a higher bone resorption. However, there was
no moderating effect of the IL6 genetic polymorphism on the relationship between and acid ash
diet and bone resorption markers among the postmenopausal women (p = 0.79). Conclusion: High
consumption of an acid ash diet and the IL6 -572 C allele seem to attribute to high bone resorption
among postmenopausal women. However, our finding does not support the interaction effect of
dietary acidity and IL6 (-174G/C and -572G/C) polymorphisms on the rate of bone resorption.
Taken together, these results have given scientific research other candidate genes to focus on which
may interact with DAL on bone resorption, to enhance planning for preventing or delaying the onset
of osteoporosis among postmenopausal women.
|
|---|