Nitric oxide modulation in neuroinflammation and the role of mesenchymal stem cells
Nitric oxide is a versatile mediator formed by enzymes called nitric oxide synthases. It has numerous homeostatic functions and important roles in inflammation. Within the inflamed brain, microglia and astrocytes produce large amounts of nitric oxide during inflammation. Excessive nitric oxide cause...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Published: |
Society for Experimental Biology and Medicine
2021
|
| Online Access: | http://psasir.upm.edu.my/id/eprint/94361/ |
| _version_ | 1848861976407572480 |
|---|---|
| author | Pan, M. Liy A. Puzi, Nur Nabilah Jose, Shinsmon Vidyadaran, Sharmili |
| author_facet | Pan, M. Liy A. Puzi, Nur Nabilah Jose, Shinsmon Vidyadaran, Sharmili |
| author_sort | Pan, M. Liy |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Nitric oxide is a versatile mediator formed by enzymes called nitric oxide synthases. It has numerous homeostatic functions and important roles in inflammation. Within the inflamed brain, microglia and astrocytes produce large amounts of nitric oxide during inflammation. Excessive nitric oxide causes neuronal toxicity and death and mesenchymal stem cells can be used as an approach to limit the neuronal damage caused by neuroinflammation. Mesenchymal stem cell therapy ameliorates inflammation and neuronal damage in disease models of Alzheimer’s disease, Parkinson’s disease, and other neuroinflammatory disorders. Interestingly, we have reported that in vitro, mesenchymal stem cells themselves contribute to a rise in nitric oxide levels through microglial cues. This may be an undesirable effect and highlights a possible need to explore acellular approaches for mesenchymal stem cell therapy in the central nervous system. |
| first_indexed | 2025-11-15T13:09:41Z |
| format | Article |
| id | upm-94361 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-15T13:09:41Z |
| publishDate | 2021 |
| publisher | Society for Experimental Biology and Medicine |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-943612023-05-03T08:43:23Z http://psasir.upm.edu.my/id/eprint/94361/ Nitric oxide modulation in neuroinflammation and the role of mesenchymal stem cells Pan, M. Liy A. Puzi, Nur Nabilah Jose, Shinsmon Vidyadaran, Sharmili Nitric oxide is a versatile mediator formed by enzymes called nitric oxide synthases. It has numerous homeostatic functions and important roles in inflammation. Within the inflamed brain, microglia and astrocytes produce large amounts of nitric oxide during inflammation. Excessive nitric oxide causes neuronal toxicity and death and mesenchymal stem cells can be used as an approach to limit the neuronal damage caused by neuroinflammation. Mesenchymal stem cell therapy ameliorates inflammation and neuronal damage in disease models of Alzheimer’s disease, Parkinson’s disease, and other neuroinflammatory disorders. Interestingly, we have reported that in vitro, mesenchymal stem cells themselves contribute to a rise in nitric oxide levels through microglial cues. This may be an undesirable effect and highlights a possible need to explore acellular approaches for mesenchymal stem cell therapy in the central nervous system. Society for Experimental Biology and Medicine 2021-03-09 Article PeerReviewed Pan, M. Liy and A. Puzi, Nur Nabilah and Jose, Shinsmon and Vidyadaran, Sharmili (2021) Nitric oxide modulation in neuroinflammation and the role of mesenchymal stem cells. Experimental Biology and Medicine, 246 (22). 2399 - 2406. ISSN 1535-3702; ESSN: 1535-3699 https://journals.sagepub.com/doi/10.1177/1535370221997052 10.1177/1535370221997052 |
| spellingShingle | Pan, M. Liy A. Puzi, Nur Nabilah Jose, Shinsmon Vidyadaran, Sharmili Nitric oxide modulation in neuroinflammation and the role of mesenchymal stem cells |
| title | Nitric oxide modulation in neuroinflammation and the role of mesenchymal stem cells |
| title_full | Nitric oxide modulation in neuroinflammation and the role of mesenchymal stem cells |
| title_fullStr | Nitric oxide modulation in neuroinflammation and the role of mesenchymal stem cells |
| title_full_unstemmed | Nitric oxide modulation in neuroinflammation and the role of mesenchymal stem cells |
| title_short | Nitric oxide modulation in neuroinflammation and the role of mesenchymal stem cells |
| title_sort | nitric oxide modulation in neuroinflammation and the role of mesenchymal stem cells |
| url | http://psasir.upm.edu.my/id/eprint/94361/ http://psasir.upm.edu.my/id/eprint/94361/ http://psasir.upm.edu.my/id/eprint/94361/ |