NeuroAid II (MLC901) and polypharmacy in stroke and the risk of hepatotoxicity: a case report
Background: NeuroAid II (MLC901) is a promising therapy for stroke patients who present outside of therapeutic window for reperfusion therapy. Studies have proven its efcacy in ischemic stroke; however, data of drug safety and combination with other medications especially anticoagulants are hetero...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
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SpringerOpen
2021
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| Online Access: | http://psasir.upm.edu.my/id/eprint/94347/ |
| _version_ | 1848861972842414080 |
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| author | Abdul Rashid, Anna Misya’il Md Noh, Mohamad Syafeeq Faeez Yusof Khan, Abdul Hanif Khan Wei, Chao Loh Baharin, Janudin Ibrahim, Azliza Inche Mat, Liyana Najwa Wan Sulaiman, Wan Aliaa Fan, Kee Hoo Hanapiah, Fazah Akhtar Basri, Hamidon |
| author_facet | Abdul Rashid, Anna Misya’il Md Noh, Mohamad Syafeeq Faeez Yusof Khan, Abdul Hanif Khan Wei, Chao Loh Baharin, Janudin Ibrahim, Azliza Inche Mat, Liyana Najwa Wan Sulaiman, Wan Aliaa Fan, Kee Hoo Hanapiah, Fazah Akhtar Basri, Hamidon |
| author_sort | Abdul Rashid, Anna Misya’il |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Background: NeuroAid II (MLC901) is a promising therapy for stroke patients who present outside of therapeutic
window for reperfusion therapy. Studies have proven its efcacy in ischemic stroke; however, data of drug safety and
combination with other medications especially anticoagulants are heterogenous. We report a possible case of hepatotoxicity induced by NeuroAid II in combination with anticoagulants.
Case presentation: We report an elderly patient who developed symptoms of cardioembolic stroke presented
outside of time window for reperfusion therapy. He was started on a regiment of statins, anticoagulation, beta blockers and NeuroAid II. One month later he presented with deranged liver enzymes. Cessation of NeuroAid II resulted in
rapid improvement of transaminitis within days.
Conclusions: We wish to highlight the potential harmful efect of administering NeuroAid II with an anticoagulant
and the importance of routine follow-up and blood monitoring in the elderly patients with stroke. |
| first_indexed | 2025-11-15T13:09:38Z |
| format | Article |
| id | upm-94347 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-15T13:09:38Z |
| publishDate | 2021 |
| publisher | SpringerOpen |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-943472023-04-07T03:45:22Z http://psasir.upm.edu.my/id/eprint/94347/ NeuroAid II (MLC901) and polypharmacy in stroke and the risk of hepatotoxicity: a case report Abdul Rashid, Anna Misya’il Md Noh, Mohamad Syafeeq Faeez Yusof Khan, Abdul Hanif Khan Wei, Chao Loh Baharin, Janudin Ibrahim, Azliza Inche Mat, Liyana Najwa Wan Sulaiman, Wan Aliaa Fan, Kee Hoo Hanapiah, Fazah Akhtar Basri, Hamidon Background: NeuroAid II (MLC901) is a promising therapy for stroke patients who present outside of therapeutic window for reperfusion therapy. Studies have proven its efcacy in ischemic stroke; however, data of drug safety and combination with other medications especially anticoagulants are heterogenous. We report a possible case of hepatotoxicity induced by NeuroAid II in combination with anticoagulants. Case presentation: We report an elderly patient who developed symptoms of cardioembolic stroke presented outside of time window for reperfusion therapy. He was started on a regiment of statins, anticoagulation, beta blockers and NeuroAid II. One month later he presented with deranged liver enzymes. Cessation of NeuroAid II resulted in rapid improvement of transaminitis within days. Conclusions: We wish to highlight the potential harmful efect of administering NeuroAid II with an anticoagulant and the importance of routine follow-up and blood monitoring in the elderly patients with stroke. SpringerOpen 2021-11 Article PeerReviewed Abdul Rashid, Anna Misya’il and Md Noh, Mohamad Syafeeq Faeez and Yusof Khan, Abdul Hanif Khan and Wei, Chao Loh and Baharin, Janudin and Ibrahim, Azliza and Inche Mat, Liyana Najwa and Wan Sulaiman, Wan Aliaa and Fan, Kee Hoo and Hanapiah, Fazah Akhtar and Basri, Hamidon (2021) NeuroAid II (MLC901) and polypharmacy in stroke and the risk of hepatotoxicity: a case report. The Egyptian Journal of Neurology, Psychiatry and Neurosurgery, 57. art. no. 151. pp. 1-6. ISSN 1687-8329 https://ejnpn.springeropen.com/articles/10.1186/s41983-021-00397-y 10.1186/s41983-021-00397-y |
| spellingShingle | Abdul Rashid, Anna Misya’il Md Noh, Mohamad Syafeeq Faeez Yusof Khan, Abdul Hanif Khan Wei, Chao Loh Baharin, Janudin Ibrahim, Azliza Inche Mat, Liyana Najwa Wan Sulaiman, Wan Aliaa Fan, Kee Hoo Hanapiah, Fazah Akhtar Basri, Hamidon NeuroAid II (MLC901) and polypharmacy in stroke and the risk of hepatotoxicity: a case report |
| title | NeuroAid II (MLC901) and polypharmacy in stroke and the risk of hepatotoxicity: a case report |
| title_full | NeuroAid II (MLC901) and polypharmacy in stroke and the risk of hepatotoxicity: a case report |
| title_fullStr | NeuroAid II (MLC901) and polypharmacy in stroke and the risk of hepatotoxicity: a case report |
| title_full_unstemmed | NeuroAid II (MLC901) and polypharmacy in stroke and the risk of hepatotoxicity: a case report |
| title_short | NeuroAid II (MLC901) and polypharmacy in stroke and the risk of hepatotoxicity: a case report |
| title_sort | neuroaid ii (mlc901) and polypharmacy in stroke and the risk of hepatotoxicity: a case report |
| url | http://psasir.upm.edu.my/id/eprint/94347/ http://psasir.upm.edu.my/id/eprint/94347/ http://psasir.upm.edu.my/id/eprint/94347/ |