Natural-based biomaterial for skin wound healing (gelatin vs. collagen): expert review
Collagen (Col) and gelatin are most extensively used in various fields, particularly in pharmaceuticals and therapeutics. Numerous researchers have proven that they are highly biocompatible to human tissues, exhibit low antigenicity and are easy to degrade. Despite their different sources both Col...
| Main Authors: | , , , |
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| Format: | Article |
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MDPI
2021
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| Online Access: | http://psasir.upm.edu.my/id/eprint/94335/ |
| _version_ | 1848861969541496832 |
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| author | Naomi, Ruth Bahari, Hasnah Muhd Ridzuan, Pauzi Othman, Fezah |
| author_facet | Naomi, Ruth Bahari, Hasnah Muhd Ridzuan, Pauzi Othman, Fezah |
| author_sort | Naomi, Ruth |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Collagen (Col) and gelatin are most extensively used in various fields, particularly in pharmaceuticals and therapeutics. Numerous researchers have proven that they are highly biocompatible
to human tissues, exhibit low antigenicity and are easy to degrade. Despite their different sources
both Col and gelatin have almost the same effects when it comes to wound healing mechanisms.
Considering this, the bioactivity and biological effects of both Col and gelatin have been, and are being, constantly investigated through in vitro and in vivo assays to obtain maximum outcomes in the
future. With regard to their proven nutritional values as sources of protein, Col and gelatin products
exert various possible biological activities on cells in the extracellular matrix (ECM). In addition, a
vast number of novel Col and gelatin applications have been discovered. This review compared Col
and gelatin in terms of their structures, sources of derivatives, physicochemical properties, results
of in vitro and in vivo studies, their roles in wound healing and the current challenges in wound
healing. Thus, this review provides the current insights and the latest discoveries on both Col and
gelatin in their wound healing mechanisms. |
| first_indexed | 2025-11-15T13:09:34Z |
| format | Article |
| id | upm-94335 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-15T13:09:34Z |
| publishDate | 2021 |
| publisher | MDPI |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-943352023-04-05T02:39:32Z http://psasir.upm.edu.my/id/eprint/94335/ Natural-based biomaterial for skin wound healing (gelatin vs. collagen): expert review Naomi, Ruth Bahari, Hasnah Muhd Ridzuan, Pauzi Othman, Fezah Collagen (Col) and gelatin are most extensively used in various fields, particularly in pharmaceuticals and therapeutics. Numerous researchers have proven that they are highly biocompatible to human tissues, exhibit low antigenicity and are easy to degrade. Despite their different sources both Col and gelatin have almost the same effects when it comes to wound healing mechanisms. Considering this, the bioactivity and biological effects of both Col and gelatin have been, and are being, constantly investigated through in vitro and in vivo assays to obtain maximum outcomes in the future. With regard to their proven nutritional values as sources of protein, Col and gelatin products exert various possible biological activities on cells in the extracellular matrix (ECM). In addition, a vast number of novel Col and gelatin applications have been discovered. This review compared Col and gelatin in terms of their structures, sources of derivatives, physicochemical properties, results of in vitro and in vivo studies, their roles in wound healing and the current challenges in wound healing. Thus, this review provides the current insights and the latest discoveries on both Col and gelatin in their wound healing mechanisms. MDPI 2021-07-14 Article PeerReviewed Naomi, Ruth and Bahari, Hasnah and Muhd Ridzuan, Pauzi and Othman, Fezah (2021) Natural-based biomaterial for skin wound healing (gelatin vs. collagen): expert review. Polymers, 13 (14). art. no. 2319. pp. 1-20. ISSN 2073-4360 https://www.mdpi.com/2073-4360/13/14/2319 10.3390/polym13142319 |
| spellingShingle | Naomi, Ruth Bahari, Hasnah Muhd Ridzuan, Pauzi Othman, Fezah Natural-based biomaterial for skin wound healing (gelatin vs. collagen): expert review |
| title | Natural-based biomaterial for skin wound healing (gelatin vs. collagen): expert review |
| title_full | Natural-based biomaterial for skin wound healing (gelatin vs. collagen): expert review |
| title_fullStr | Natural-based biomaterial for skin wound healing (gelatin vs. collagen): expert review |
| title_full_unstemmed | Natural-based biomaterial for skin wound healing (gelatin vs. collagen): expert review |
| title_short | Natural-based biomaterial for skin wound healing (gelatin vs. collagen): expert review |
| title_sort | natural-based biomaterial for skin wound healing (gelatin vs. collagen): expert review |
| url | http://psasir.upm.edu.my/id/eprint/94335/ http://psasir.upm.edu.my/id/eprint/94335/ http://psasir.upm.edu.my/id/eprint/94335/ |