The Effect of Aloe Vera, Vitamin C and E on Tumour Marker Enzymes in Hepatocarcinogenesis
The effects of Aloe vera (AV), vitamin C (VC), alpha-tocopherol (T) and gamma-tocotrienol (E) on the activities of six tumour marker enzymes; alkaline phosphatase (ALP), glutathione-S-transferase (GST), gamma-glutamyl transferase (GGT), glutathione peroxidase (GPx), glutathione reductase (GRx) an...
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| Format: | Thesis |
| Language: | English English |
| Published: |
1998
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| Subjects: | |
| Online Access: | http://psasir.upm.edu.my/id/eprint/9433/ http://psasir.upm.edu.my/id/eprint/9433/1/FSAS_1998_24_A.pdf |
| _version_ | 1848841145009831936 |
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| author | Md Akim, Abdah |
| author_facet | Md Akim, Abdah |
| author_sort | Md Akim, Abdah |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | The effects of Aloe vera (AV), vitamin C (VC), alpha-tocopherol (T) and
gamma-tocotrienol (E) on the activities of six tumour marker enzymes; alkaline
phosphatase (ALP), glutathione-S-transferase (GST), gamma-glutamyl transferase
(GGT), glutathione peroxidase (GPx), glutathione reductase (GRx) and uridyl
diphosphoglucuronyl transferase (UDPGT) in rat liver carcinogenesis were studied.
Liver cancer was induced by diethylnitrosamine (DEN) and 2 -acetylaminofluorene
(AAF) followed by partial hepatectomy. Ninety male rats (Rattus norwegicus, 120-
150g, 6-7 weeks old) were divided into 15 groups. Six groups comprised the normal
and supplemented-control groups. Hepatocarcinogenesis was induced in the other
nine groups. Four groups were supplemented with AV, VC, E and T respectively
and the other 4 groups were given TNC, T/AV, ENC and E/AV respectively. The
last group remained as the cancer-control group. Aloe vera and vitamin C were administered ad libitum at doses of 0.1 mg/L
water and 41.7 mg/L water respectively, in both control and cancer groups. Alphatocopherol
and gamma-tocotrienol were administered at a dose of 34 mglkg diet and
30 mglkg diet, respectively. The rats were sacrificed by cervical dislocation after 16
weeks.
An increase (p<0.05) in all six tumour marker enzymes was observed in the
cancer-treated group compared to the normal-control group. Aloe vera
supplementation significantly (p<0.05) decreased the tumour marker enzyme
activities in cancer-induced liver compared to the cancer-control group. Gammatocotrienol
exerted a better effect than alpha-tocopherol in reducing the enzyme
activities in cancer-induced liver. Vitamin C significantly (p<0.05) decreased the
enzyme activities in GPx, GRx, GST and UDPGT. However, non of the
supplementations decreased the alkaline phosphatase activity in the liver cancer. |
| first_indexed | 2025-11-15T07:38:35Z |
| format | Thesis |
| id | upm-9433 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-15T07:38:35Z |
| publishDate | 1998 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-94332024-02-29T09:20:07Z http://psasir.upm.edu.my/id/eprint/9433/ The Effect of Aloe Vera, Vitamin C and E on Tumour Marker Enzymes in Hepatocarcinogenesis Md Akim, Abdah The effects of Aloe vera (AV), vitamin C (VC), alpha-tocopherol (T) and gamma-tocotrienol (E) on the activities of six tumour marker enzymes; alkaline phosphatase (ALP), glutathione-S-transferase (GST), gamma-glutamyl transferase (GGT), glutathione peroxidase (GPx), glutathione reductase (GRx) and uridyl diphosphoglucuronyl transferase (UDPGT) in rat liver carcinogenesis were studied. Liver cancer was induced by diethylnitrosamine (DEN) and 2 -acetylaminofluorene (AAF) followed by partial hepatectomy. Ninety male rats (Rattus norwegicus, 120- 150g, 6-7 weeks old) were divided into 15 groups. Six groups comprised the normal and supplemented-control groups. Hepatocarcinogenesis was induced in the other nine groups. Four groups were supplemented with AV, VC, E and T respectively and the other 4 groups were given TNC, T/AV, ENC and E/AV respectively. The last group remained as the cancer-control group. Aloe vera and vitamin C were administered ad libitum at doses of 0.1 mg/L water and 41.7 mg/L water respectively, in both control and cancer groups. Alphatocopherol and gamma-tocotrienol were administered at a dose of 34 mglkg diet and 30 mglkg diet, respectively. The rats were sacrificed by cervical dislocation after 16 weeks. An increase (p<0.05) in all six tumour marker enzymes was observed in the cancer-treated group compared to the normal-control group. Aloe vera supplementation significantly (p<0.05) decreased the tumour marker enzyme activities in cancer-induced liver compared to the cancer-control group. Gammatocotrienol exerted a better effect than alpha-tocopherol in reducing the enzyme activities in cancer-induced liver. Vitamin C significantly (p<0.05) decreased the enzyme activities in GPx, GRx, GST and UDPGT. However, non of the supplementations decreased the alkaline phosphatase activity in the liver cancer. 1998-02 Thesis NonPeerReviewed application/pdf en http://psasir.upm.edu.my/id/eprint/9433/1/FSAS_1998_24_A.pdf Md Akim, Abdah (1998) The Effect of Aloe Vera, Vitamin C and E on Tumour Marker Enzymes in Hepatocarcinogenesis. Masters thesis, Universiti Putra Malaysia. Tumor markers Aloe vera Vitamin E English |
| spellingShingle | Tumor markers Aloe vera Vitamin E Md Akim, Abdah The Effect of Aloe Vera, Vitamin C and E on Tumour Marker Enzymes in Hepatocarcinogenesis |
| title | The Effect of Aloe Vera, Vitamin C and E on Tumour Marker Enzymes in Hepatocarcinogenesis |
| title_full | The Effect of Aloe Vera, Vitamin C and E on Tumour Marker Enzymes in Hepatocarcinogenesis |
| title_fullStr | The Effect of Aloe Vera, Vitamin C and E on Tumour Marker Enzymes in Hepatocarcinogenesis |
| title_full_unstemmed | The Effect of Aloe Vera, Vitamin C and E on Tumour Marker Enzymes in Hepatocarcinogenesis |
| title_short | The Effect of Aloe Vera, Vitamin C and E on Tumour Marker Enzymes in Hepatocarcinogenesis |
| title_sort | effect of aloe vera, vitamin c and e on tumour marker enzymes in hepatocarcinogenesis |
| topic | Tumor markers Aloe vera Vitamin E |
| url | http://psasir.upm.edu.my/id/eprint/9433/ http://psasir.upm.edu.my/id/eprint/9433/1/FSAS_1998_24_A.pdf |