Nanomaterials-upconverted hydroxyapatite for bone tissue engineering and a platform for drug delivery
Hydroxyapatite is a basic mineral that is very important to the human body framework. Recently, synthetic hydroxyapatite (SHA) and its nanocomposites (HANs) are the subject of intense research for bone tissue engineering and drug loading system applications, due to their unique, tailor-made characte...
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| Format: | Article |
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Taylor and Francis Group
2021
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| Online Access: | http://psasir.upm.edu.my/id/eprint/94321/ |
| _version_ | 1848861965453099008 |
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| author | Abdul Halim, Nur Akma Hussein, Mohd Zobir Kandar, Mohd Khairuddin |
| author_facet | Abdul Halim, Nur Akma Hussein, Mohd Zobir Kandar, Mohd Khairuddin |
| author_sort | Abdul Halim, Nur Akma |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Hydroxyapatite is a basic mineral that is very important to the human body framework. Recently, synthetic hydroxyapatite (SHA) and its nanocomposites (HANs) are the subject of intense research for bone tissue engineering and drug loading system applications, due to their unique, tailor-made characteristics, as well as their similarities with the bone mineral component in the human body. Although hydroxyapatite has good biocompatibility and osteoconductive characteristics, the poor mechanical strength restricts its use in non-load-bearing applications. Consequently, a rapid increase in reinforcing of other nanomaterials into hydroxyapatite for the formation of HANs could improve the mechanical properties. Most of the research reported on the success of other nanomaterials such as metals, ceramics and natural/synthetic polymers as additions into hydroxyapatite is reviewed. In addition, this review also focuses on the addition of various substances into hydroxyapatite for the formation of various HANs and at the same time to try to minimize the limitations so that various bone tissue engineering and drug loading system applications can be exploited. |
| first_indexed | 2025-11-15T13:09:30Z |
| format | Article |
| id | upm-94321 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-15T13:09:30Z |
| publishDate | 2021 |
| publisher | Taylor and Francis Group |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-943212023-05-08T03:59:49Z http://psasir.upm.edu.my/id/eprint/94321/ Nanomaterials-upconverted hydroxyapatite for bone tissue engineering and a platform for drug delivery Abdul Halim, Nur Akma Hussein, Mohd Zobir Kandar, Mohd Khairuddin Hydroxyapatite is a basic mineral that is very important to the human body framework. Recently, synthetic hydroxyapatite (SHA) and its nanocomposites (HANs) are the subject of intense research for bone tissue engineering and drug loading system applications, due to their unique, tailor-made characteristics, as well as their similarities with the bone mineral component in the human body. Although hydroxyapatite has good biocompatibility and osteoconductive characteristics, the poor mechanical strength restricts its use in non-load-bearing applications. Consequently, a rapid increase in reinforcing of other nanomaterials into hydroxyapatite for the formation of HANs could improve the mechanical properties. Most of the research reported on the success of other nanomaterials such as metals, ceramics and natural/synthetic polymers as additions into hydroxyapatite is reviewed. In addition, this review also focuses on the addition of various substances into hydroxyapatite for the formation of various HANs and at the same time to try to minimize the limitations so that various bone tissue engineering and drug loading system applications can be exploited. Taylor and Francis Group 2021-09-21 Article PeerReviewed Abdul Halim, Nur Akma and Hussein, Mohd Zobir and Kandar, Mohd Khairuddin (2021) Nanomaterials-upconverted hydroxyapatite for bone tissue engineering and a platform for drug delivery. International Journal of Nanomedicine, 16. pp. 6477-6496. ISSN 1176-9114; ESSN: 1178-2013 https://www.dovepress.com/nanomaterials-upconverted-hydroxyapatite-for-bone-tissue-engineering-a-peer-reviewed-fulltext-article-IJN 10.2147/IJN.S298936 |
| spellingShingle | Abdul Halim, Nur Akma Hussein, Mohd Zobir Kandar, Mohd Khairuddin Nanomaterials-upconverted hydroxyapatite for bone tissue engineering and a platform for drug delivery |
| title | Nanomaterials-upconverted hydroxyapatite for bone tissue engineering and a platform for drug delivery |
| title_full | Nanomaterials-upconverted hydroxyapatite for bone tissue engineering and a platform for drug delivery |
| title_fullStr | Nanomaterials-upconverted hydroxyapatite for bone tissue engineering and a platform for drug delivery |
| title_full_unstemmed | Nanomaterials-upconverted hydroxyapatite for bone tissue engineering and a platform for drug delivery |
| title_short | Nanomaterials-upconverted hydroxyapatite for bone tissue engineering and a platform for drug delivery |
| title_sort | nanomaterials-upconverted hydroxyapatite for bone tissue engineering and a platform for drug delivery |
| url | http://psasir.upm.edu.my/id/eprint/94321/ http://psasir.upm.edu.my/id/eprint/94321/ http://psasir.upm.edu.my/id/eprint/94321/ |