Manipulation of gut microbiota using acacia gum polysaccharide
Acacia gum (AG) is a branched-polysaccharide gummy exudate that consists of arabinose and galactose. The traditional practice in African-Middle Eastern countries uses this gum as medicine. Traditional use of AG is to treat stomach disease, which can be a potential functional food. In this research,...
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| Format: | Article |
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American Chemical Society
2021
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| Online Access: | http://psasir.upm.edu.my/id/eprint/94096/ |
| _version_ | 1848861909573435392 |
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| author | Rawi, Muhamad Hanif Abdullah, Aminah Ismail, Amin Sarbini, Shahrul Razid |
| author_facet | Rawi, Muhamad Hanif Abdullah, Aminah Ismail, Amin Sarbini, Shahrul Razid |
| author_sort | Rawi, Muhamad Hanif |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Acacia gum (AG) is a branched-polysaccharide gummy exudate that consists of arabinose and galactose. The traditional practice in African-Middle Eastern countries uses this gum as medicine. Traditional use of AG is to treat stomach disease, which can be a potential functional food. In this research, commercially available AG from Acacia senegal and Acacia seyal was investigated as the prebiotic. The experiment employed a pH-controlled in vitro colon model inoculated with human fecal microbiota to mimic the human colon. Fermentation samples at 0, 6, 12, and 24 h were brought for short-chain fatty acid (SCFA) analysis using high-performance liquid chromatography and bacterial enumeration via fluorescent in situ hybridization. Results showed that AG significantly promotes Bifidobacteria proliferation similar to fructo-oligosaccharides (FOS) while inhibiting the Clostridium histolyticum group, commonly associated with gut dysbiosis. Acetate, propionate, and butyrate showed a similar trend to FOS (p > 0.05). The AG shows potential against gut dysbiosis, as it promotes gut-probiotics, through modulation of microbial population and SCFA production, especially butyrate. |
| first_indexed | 2025-11-15T13:08:37Z |
| format | Article |
| id | upm-94096 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-15T13:08:37Z |
| publishDate | 2021 |
| publisher | American Chemical Society |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-940962024-05-02T07:07:25Z http://psasir.upm.edu.my/id/eprint/94096/ Manipulation of gut microbiota using acacia gum polysaccharide Rawi, Muhamad Hanif Abdullah, Aminah Ismail, Amin Sarbini, Shahrul Razid Acacia gum (AG) is a branched-polysaccharide gummy exudate that consists of arabinose and galactose. The traditional practice in African-Middle Eastern countries uses this gum as medicine. Traditional use of AG is to treat stomach disease, which can be a potential functional food. In this research, commercially available AG from Acacia senegal and Acacia seyal was investigated as the prebiotic. The experiment employed a pH-controlled in vitro colon model inoculated with human fecal microbiota to mimic the human colon. Fermentation samples at 0, 6, 12, and 24 h were brought for short-chain fatty acid (SCFA) analysis using high-performance liquid chromatography and bacterial enumeration via fluorescent in situ hybridization. Results showed that AG significantly promotes Bifidobacteria proliferation similar to fructo-oligosaccharides (FOS) while inhibiting the Clostridium histolyticum group, commonly associated with gut dysbiosis. Acetate, propionate, and butyrate showed a similar trend to FOS (p > 0.05). The AG shows potential against gut dysbiosis, as it promotes gut-probiotics, through modulation of microbial population and SCFA production, especially butyrate. American Chemical Society 2021 Article PeerReviewed Rawi, Muhamad Hanif and Abdullah, Aminah and Ismail, Amin and Sarbini, Shahrul Razid (2021) Manipulation of gut microbiota using acacia gum polysaccharide. ACS Omega, 6 (28). pp. 17782-17797. ISSN 2470-1343; ESSN: 2470-1343 https://pubs.acs.org/doi/10.1021/acsomega.1c00302 10.1021/acsomega.1c00302 |
| spellingShingle | Rawi, Muhamad Hanif Abdullah, Aminah Ismail, Amin Sarbini, Shahrul Razid Manipulation of gut microbiota using acacia gum polysaccharide |
| title | Manipulation of gut microbiota using acacia gum polysaccharide |
| title_full | Manipulation of gut microbiota using acacia gum polysaccharide |
| title_fullStr | Manipulation of gut microbiota using acacia gum polysaccharide |
| title_full_unstemmed | Manipulation of gut microbiota using acacia gum polysaccharide |
| title_short | Manipulation of gut microbiota using acacia gum polysaccharide |
| title_sort | manipulation of gut microbiota using acacia gum polysaccharide |
| url | http://psasir.upm.edu.my/id/eprint/94096/ http://psasir.upm.edu.my/id/eprint/94096/ http://psasir.upm.edu.my/id/eprint/94096/ |