Is malnutrition a determining factor of health-related quality of life in hemodialysis patients? a cross-sectional design examining relationships with a comprehensive assessment of nutritional status
Purpose: To identify relationships between health-related quality of life (HRQOL) and nutritional status in hemodialysis (HD) patients. Method: Secondary data from a cross-sectional survey was utilized. HRQOL was assessed for 379 HD patients using the generic Short Form 36 (SF-36) and disease-specif...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
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Springer Dordrecht
2021
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| Online Access: | http://psasir.upm.edu.my/id/eprint/93922/ |
| _version_ | 1848861881029099520 |
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| author | Ng, Hi-Ming Khor, Ban-Hock Sahathevan, Sharmela Sualeheen, Ayesha Chinna, Karuthan Abdul Gafor, Abdul Halim Goh, Bak-Leong Ahmad, Ghazali Morad, Zaki Mat Daud, Zulfitri Azuan Khosla, Pramod Karupaiah, Tilakavati |
| author_facet | Ng, Hi-Ming Khor, Ban-Hock Sahathevan, Sharmela Sualeheen, Ayesha Chinna, Karuthan Abdul Gafor, Abdul Halim Goh, Bak-Leong Ahmad, Ghazali Morad, Zaki Mat Daud, Zulfitri Azuan Khosla, Pramod Karupaiah, Tilakavati |
| author_sort | Ng, Hi-Ming |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Purpose: To identify relationships between health-related quality of life (HRQOL) and nutritional status in hemodialysis (HD) patients. Method: Secondary data from a cross-sectional survey was utilized. HRQOL was assessed for 379 HD patients using the generic Short Form 36 (SF-36) and disease-specific Kidney-Disease Quality of Life-36 (KDQOL-36). Malnutrition was indicated by malnutrition inflammation score (MIS) ≥ 5, and presence of protein-energy wasting (PEW). The individual nutritional parameters included the domains of physical status, serum biomarkers, and dietary intake. Multivariate associations were assessed using the general linear model. Results: MIS ≥ 5 was negatively associated with SF-36 scores of physical functioning (MIS < 5 = 73.4 ± 8.0 SE vs MIS ≥ 5 = 64.6 ± 7.7 SE, P < 0.001), role-limitation-physical (MIS < 5 = 65.3 ± 14.3 SE vs MIS ≥ 5 = 52.9 ± 14.0 SE, P = 0.006), general health (MIS < 5 = 53.7 ± 7.5 SE vs MIS ≥ 5 = 47.0 ± 7.1 SE, P = 0.003), and PCS-36 (MIS < 5 = 40.5 ± 3.3 SE vs MIS ≥ 5 = 35.9 ± 3.1 SE, P < 0.001); and KDQOL-36 score of symptoms/problems (MIS < 5 = 78.9 ± 5.6 SE vs MIS ≥ 5 = 74.8 ± 5.4 SE, P = 0.022), but not with PEW by any tool. Of individual nutritional parameters, underweight (68.1 ± 5.4 SE, P = 0.031), normal weight (63.8 ± 2.8 SE, P = 0.023), and overweight (64.3 ± 2.9 SE, P = 0.003) patients had significantly higher physical functioning scores compared to obese patients (44.8 ± 5.5 SE). Serum albumin levels were positively associated with physical functioning (P = 0.041) score. HGS was also positively associated with physical functioning (P = 0.036), and vitality (P = 0.041) scores. Greater dietary phosphorus intakes were significantly associated with lower scores for role limitation-physical (P = 0.008), bodily pain (P = 0.043), and PCS-36 (P = 0.024). Conclusion: Malnutrition diagnosis by MIS, but not PEW, indicated associations with HRQOL in HD patients. Individual nutritional parameters that related to higher HRQOL were BMI < 30 kg/m2, better dietary phosphorus control, greater muscle strength and higher visceral protein pool. |
| first_indexed | 2025-11-15T13:08:10Z |
| format | Article |
| id | upm-93922 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| last_indexed | 2025-11-15T13:08:10Z |
| publishDate | 2021 |
| publisher | Springer Dordrecht |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-939222023-04-12T04:16:13Z http://psasir.upm.edu.my/id/eprint/93922/ Is malnutrition a determining factor of health-related quality of life in hemodialysis patients? a cross-sectional design examining relationships with a comprehensive assessment of nutritional status Ng, Hi-Ming Khor, Ban-Hock Sahathevan, Sharmela Sualeheen, Ayesha Chinna, Karuthan Abdul Gafor, Abdul Halim Goh, Bak-Leong Ahmad, Ghazali Morad, Zaki Mat Daud, Zulfitri Azuan Khosla, Pramod Karupaiah, Tilakavati Purpose: To identify relationships between health-related quality of life (HRQOL) and nutritional status in hemodialysis (HD) patients. Method: Secondary data from a cross-sectional survey was utilized. HRQOL was assessed for 379 HD patients using the generic Short Form 36 (SF-36) and disease-specific Kidney-Disease Quality of Life-36 (KDQOL-36). Malnutrition was indicated by malnutrition inflammation score (MIS) ≥ 5, and presence of protein-energy wasting (PEW). The individual nutritional parameters included the domains of physical status, serum biomarkers, and dietary intake. Multivariate associations were assessed using the general linear model. Results: MIS ≥ 5 was negatively associated with SF-36 scores of physical functioning (MIS < 5 = 73.4 ± 8.0 SE vs MIS ≥ 5 = 64.6 ± 7.7 SE, P < 0.001), role-limitation-physical (MIS < 5 = 65.3 ± 14.3 SE vs MIS ≥ 5 = 52.9 ± 14.0 SE, P = 0.006), general health (MIS < 5 = 53.7 ± 7.5 SE vs MIS ≥ 5 = 47.0 ± 7.1 SE, P = 0.003), and PCS-36 (MIS < 5 = 40.5 ± 3.3 SE vs MIS ≥ 5 = 35.9 ± 3.1 SE, P < 0.001); and KDQOL-36 score of symptoms/problems (MIS < 5 = 78.9 ± 5.6 SE vs MIS ≥ 5 = 74.8 ± 5.4 SE, P = 0.022), but not with PEW by any tool. Of individual nutritional parameters, underweight (68.1 ± 5.4 SE, P = 0.031), normal weight (63.8 ± 2.8 SE, P = 0.023), and overweight (64.3 ± 2.9 SE, P = 0.003) patients had significantly higher physical functioning scores compared to obese patients (44.8 ± 5.5 SE). Serum albumin levels were positively associated with physical functioning (P = 0.041) score. HGS was also positively associated with physical functioning (P = 0.036), and vitality (P = 0.041) scores. Greater dietary phosphorus intakes were significantly associated with lower scores for role limitation-physical (P = 0.008), bodily pain (P = 0.043), and PCS-36 (P = 0.024). Conclusion: Malnutrition diagnosis by MIS, but not PEW, indicated associations with HRQOL in HD patients. Individual nutritional parameters that related to higher HRQOL were BMI < 30 kg/m2, better dietary phosphorus control, greater muscle strength and higher visceral protein pool. Springer Dordrecht 2021-11-08 Article PeerReviewed Ng, Hi-Ming and Khor, Ban-Hock and Sahathevan, Sharmela and Sualeheen, Ayesha and Chinna, Karuthan and Abdul Gafor, Abdul Halim and Goh, Bak-Leong and Ahmad, Ghazali and Morad, Zaki and Mat Daud, Zulfitri Azuan and Khosla, Pramod and Karupaiah, Tilakavati (2021) Is malnutrition a determining factor of health-related quality of life in hemodialysis patients? a cross-sectional design examining relationships with a comprehensive assessment of nutritional status. Quality of Life Research, 31 (5). pp. 1441-1459. ISSN 0962-9343; ESSN: 1573-2649 https://link.springer.com/article/10.1007/s11136-021-03018-6 10.1007/s11136-021-03018-6 |
| spellingShingle | Ng, Hi-Ming Khor, Ban-Hock Sahathevan, Sharmela Sualeheen, Ayesha Chinna, Karuthan Abdul Gafor, Abdul Halim Goh, Bak-Leong Ahmad, Ghazali Morad, Zaki Mat Daud, Zulfitri Azuan Khosla, Pramod Karupaiah, Tilakavati Is malnutrition a determining factor of health-related quality of life in hemodialysis patients? a cross-sectional design examining relationships with a comprehensive assessment of nutritional status |
| title | Is malnutrition a determining factor of health-related quality of life in hemodialysis patients? a cross-sectional design examining relationships with a comprehensive assessment of nutritional status |
| title_full | Is malnutrition a determining factor of health-related quality of life in hemodialysis patients? a cross-sectional design examining relationships with a comprehensive assessment of nutritional status |
| title_fullStr | Is malnutrition a determining factor of health-related quality of life in hemodialysis patients? a cross-sectional design examining relationships with a comprehensive assessment of nutritional status |
| title_full_unstemmed | Is malnutrition a determining factor of health-related quality of life in hemodialysis patients? a cross-sectional design examining relationships with a comprehensive assessment of nutritional status |
| title_short | Is malnutrition a determining factor of health-related quality of life in hemodialysis patients? a cross-sectional design examining relationships with a comprehensive assessment of nutritional status |
| title_sort | is malnutrition a determining factor of health-related quality of life in hemodialysis patients? a cross-sectional design examining relationships with a comprehensive assessment of nutritional status |
| url | http://psasir.upm.edu.my/id/eprint/93922/ http://psasir.upm.edu.my/id/eprint/93922/ http://psasir.upm.edu.my/id/eprint/93922/ |