Zerumbone ameliorates neuropathic pain symptoms via cannabinoid and ppar receptors using in vivo and in silico models

Neuropathic pain is a chronic pain condition persisting past the presence of any noxious stimulus or inflammation. Zerumbone, of the Zingiber zerumbet ginger plant, has exhibited anti-allodynic and antihyperalgesic effects in a neuropathic pain animal model, amongst other pharmacological properties....

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Main Authors:	Chia, Jasmine Siew Min, Farouk, Ahmad Akira Omar, Mohamad, Tengku Azam Shah Tengku, Sulaiman, Mohd Roslan, Zakaria, Hanis, Hassan, Nurul Izzaty
Format:	Article
Language:	English
Published:	MDPI AG 2021
Online Access:	http://psasir.upm.edu.my/id/eprint/93618/ http://psasir.upm.edu.my/id/eprint/93618/1/93618.pdf

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author	Chia, Jasmine Siew Min Farouk, Ahmad Akira Omar Mohamad, Tengku Azam Shah Tengku Sulaiman, Mohd Roslan Zakaria, Hanis Hassan, Nurul Izzaty
author_facet	Chia, Jasmine Siew Min Farouk, Ahmad Akira Omar Mohamad, Tengku Azam Shah Tengku Sulaiman, Mohd Roslan Zakaria, Hanis Hassan, Nurul Izzaty
author_sort	Chia, Jasmine Siew Min
building	UPM Institutional Repository
collection	Online Access
description	Neuropathic pain is a chronic pain condition persisting past the presence of any noxious stimulus or inflammation. Zerumbone, of the Zingiber zerumbet ginger plant, has exhibited anti-allodynic and antihyperalgesic effects in a neuropathic pain animal model, amongst other pharmacological properties. This study was conducted to further elucidate the mechanisms underlying zerumbone’s antineuropathic actions. Research on therapeutic agents involving cannabinoid (CB) and peroxisome proliferator-activated receptors (PPARs) is rising. These receptor systems have shown importance in causing a synergistic effect in suppressing nociceptive processing. Behavioural responses were assessed using the von Frey filament test (mechanical allodynia) and Hargreaves plantar test (thermal hyperalgesia), in chronic constriction injury (CCI) neuropathic pain mice. Antagonists SR141716 (CB1 receptor), SR144528 (CB2 receptor), GW6471 (PPARα receptor) and GW9662 (PPARγ receptor) were pre-administered before the zerumbone treatment. Our findings indicated the involvement of CB1, PPARα and PPARγ in zerumbone’s action against mechanical allodynia, whereas only CB1 and PPARα were involved against thermal hyperalgesia. Molecular docking studies also suggest that zerumbone has a comparable and favourable binding affinity against the respective agonist on the CB and PPAR receptors studied. This finding will contribute to advance our knowledge on zerumbone and its significance in treating neuropathic pain.
first_indexed	2025-11-15T13:08:07Z
format	Article
id	upm-93618
institution	Universiti Putra Malaysia
institution_category	Local University
language	English
last_indexed	2025-11-15T13:08:07Z
publishDate	2021
publisher	MDPI AG
recordtype	eprints
repository_type	Digital Repository
spelling	upm-936182025-06-03T03:02:21Z http://psasir.upm.edu.my/id/eprint/93618/ Zerumbone ameliorates neuropathic pain symptoms via cannabinoid and ppar receptors using in vivo and in silico models Chia, Jasmine Siew Min Farouk, Ahmad Akira Omar Mohamad, Tengku Azam Shah Tengku Sulaiman, Mohd Roslan Zakaria, Hanis Hassan, Nurul Izzaty Neuropathic pain is a chronic pain condition persisting past the presence of any noxious stimulus or inflammation. Zerumbone, of the Zingiber zerumbet ginger plant, has exhibited anti-allodynic and antihyperalgesic effects in a neuropathic pain animal model, amongst other pharmacological properties. This study was conducted to further elucidate the mechanisms underlying zerumbone’s antineuropathic actions. Research on therapeutic agents involving cannabinoid (CB) and peroxisome proliferator-activated receptors (PPARs) is rising. These receptor systems have shown importance in causing a synergistic effect in suppressing nociceptive processing. Behavioural responses were assessed using the von Frey filament test (mechanical allodynia) and Hargreaves plantar test (thermal hyperalgesia), in chronic constriction injury (CCI) neuropathic pain mice. Antagonists SR141716 (CB1 receptor), SR144528 (CB2 receptor), GW6471 (PPARα receptor) and GW9662 (PPARγ receptor) were pre-administered before the zerumbone treatment. Our findings indicated the involvement of CB1, PPARα and PPARγ in zerumbone’s action against mechanical allodynia, whereas only CB1 and PPARα were involved against thermal hyperalgesia. Molecular docking studies also suggest that zerumbone has a comparable and favourable binding affinity against the respective agonist on the CB and PPAR receptors studied. This finding will contribute to advance our knowledge on zerumbone and its significance in treating neuropathic pain. MDPI AG 2021-06 Article PeerReviewed text en cc_by_4 http://psasir.upm.edu.my/id/eprint/93618/1/93618.pdf Chia, Jasmine Siew Min and Farouk, Ahmad Akira Omar and Mohamad, Tengku Azam Shah Tengku and Sulaiman, Mohd Roslan and Zakaria, Hanis and Hassan, Nurul Izzaty (2021) Zerumbone ameliorates neuropathic pain symptoms via cannabinoid and ppar receptors using in vivo and in silico models. Molecules, 26 (13). art. no. 3849. ISSN 1420-3049; eISSN: 1420-3049 https://www.mdpi.com/1420-3049/26/13/3849 10.3390/molecules26133849
spellingShingle	Chia, Jasmine Siew Min Farouk, Ahmad Akira Omar Mohamad, Tengku Azam Shah Tengku Sulaiman, Mohd Roslan Zakaria, Hanis Hassan, Nurul Izzaty Zerumbone ameliorates neuropathic pain symptoms via cannabinoid and ppar receptors using in vivo and in silico models
title	Zerumbone ameliorates neuropathic pain symptoms via cannabinoid and ppar receptors using in vivo and in silico models
title_full	Zerumbone ameliorates neuropathic pain symptoms via cannabinoid and ppar receptors using in vivo and in silico models
title_fullStr	Zerumbone ameliorates neuropathic pain symptoms via cannabinoid and ppar receptors using in vivo and in silico models
title_full_unstemmed	Zerumbone ameliorates neuropathic pain symptoms via cannabinoid and ppar receptors using in vivo and in silico models
title_short	Zerumbone ameliorates neuropathic pain symptoms via cannabinoid and ppar receptors using in vivo and in silico models
title_sort	zerumbone ameliorates neuropathic pain symptoms via cannabinoid and ppar receptors using in vivo and in silico models
url	http://psasir.upm.edu.my/id/eprint/93618/ http://psasir.upm.edu.my/id/eprint/93618/ http://psasir.upm.edu.my/id/eprint/93618/ http://psasir.upm.edu.my/id/eprint/93618/1/93618.pdf

Zerumbone ameliorates neuropathic pain symptoms via cannabinoid and ppar receptors using in vivo and in silico models

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