Nutritional characteristics and clinical outcomes of critically ill patients with and without diabetes mellitus: a single-center prospective observational study in Malaysia
Introduction: This study aimed to compare the nutritional characteristics and clinical outcomes among critically ill patients with diabetes (DM) and without diabetes (WDM). Methods: Mechanically ventilated, critically ill patients who were admitted into the intensive care unit (ICU) within 48 hours...
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| Format: | Article |
| Language: | English |
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Faculty of Medicine and Health Sciences, Universiti Putra Malaysia
2020
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| Online Access: | http://psasir.upm.edu.my/id/eprint/90277/ http://psasir.upm.edu.my/id/eprint/90277/1/15upm.pdf |
| _version_ | 1848861024061489152 |
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| author | Lee, Zheng Yii Ibrahim, Noor Airini Osama, Hamdy Mohd Yusof, Barakatun Nisak |
| author_facet | Lee, Zheng Yii Ibrahim, Noor Airini Osama, Hamdy Mohd Yusof, Barakatun Nisak |
| author_sort | Lee, Zheng Yii |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Introduction: This study aimed to compare the nutritional characteristics and clinical outcomes among critically ill patients with diabetes (DM) and without diabetes (WDM). Methods: Mechanically ventilated, critically ill patients who were admitted into the intensive care unit (ICU) within 48 hours and remained in ICU ≥72 hours were prospectively recruited and followed for up to 12 days. They were stratified to DM or WDM, depending on their diabetes status at ICU admission and comparison were made for nutritional characteristics and clinical outcomes including 60-day mortality. Results: A total of 154 patients were included with 73 (47.4%) DM patients. In comparison to WDM, patients with DM were older, more severely ill, had higher nutritional risk and body mass index, presented with a higher blood glucose level, and required more insulin. DM was fed relatively earlier but had lower energy adequacy. They experienced more frequent EN interruption. Both groups had comparable ICU and hospital stay, ventilation support duration and mortality. In multivariable logistic regression, no association was found between diabetes status and for ICU and hospital mortality. However, There was a trend towards an increase in 60-day mortality in DM patients (Odds Ratio: 2.220, 95% Confidence Interval: 0.764-6.452; p=0.143). Conclusion: Critically ill patients with DM had higher nutritional risks, were fed relatively earlier, but with frequent EN interruption leading to lower energy adequacy than patients WDM. Diabetes status does not affect clinical outcomes. |
| first_indexed | 2025-11-15T12:54:33Z |
| format | Article |
| id | upm-90277 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T12:54:33Z |
| publishDate | 2020 |
| publisher | Faculty of Medicine and Health Sciences, Universiti Putra Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-902772021-09-09T22:53:17Z http://psasir.upm.edu.my/id/eprint/90277/ Nutritional characteristics and clinical outcomes of critically ill patients with and without diabetes mellitus: a single-center prospective observational study in Malaysia Lee, Zheng Yii Ibrahim, Noor Airini Osama, Hamdy Mohd Yusof, Barakatun Nisak Introduction: This study aimed to compare the nutritional characteristics and clinical outcomes among critically ill patients with diabetes (DM) and without diabetes (WDM). Methods: Mechanically ventilated, critically ill patients who were admitted into the intensive care unit (ICU) within 48 hours and remained in ICU ≥72 hours were prospectively recruited and followed for up to 12 days. They were stratified to DM or WDM, depending on their diabetes status at ICU admission and comparison were made for nutritional characteristics and clinical outcomes including 60-day mortality. Results: A total of 154 patients were included with 73 (47.4%) DM patients. In comparison to WDM, patients with DM were older, more severely ill, had higher nutritional risk and body mass index, presented with a higher blood glucose level, and required more insulin. DM was fed relatively earlier but had lower energy adequacy. They experienced more frequent EN interruption. Both groups had comparable ICU and hospital stay, ventilation support duration and mortality. In multivariable logistic regression, no association was found between diabetes status and for ICU and hospital mortality. However, There was a trend towards an increase in 60-day mortality in DM patients (Odds Ratio: 2.220, 95% Confidence Interval: 0.764-6.452; p=0.143). Conclusion: Critically ill patients with DM had higher nutritional risks, were fed relatively earlier, but with frequent EN interruption leading to lower energy adequacy than patients WDM. Diabetes status does not affect clinical outcomes. Faculty of Medicine and Health Sciences, Universiti Putra Malaysia 2020-08 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/90277/1/15upm.pdf Lee, Zheng Yii and Ibrahim, Noor Airini and Osama, Hamdy and Mohd Yusof, Barakatun Nisak (2020) Nutritional characteristics and clinical outcomes of critically ill patients with and without diabetes mellitus: a single-center prospective observational study in Malaysia. Malaysian Journal of Medicine and Health Sciences, 16 (suppl. 6). pp. 116-121. ISSN 1675-8544; ESSN: 2636-9346 https://medic.upm.edu.my/upload/dokumen/2020081208265415_MJMHS_0060_L.pdf |
| spellingShingle | Lee, Zheng Yii Ibrahim, Noor Airini Osama, Hamdy Mohd Yusof, Barakatun Nisak Nutritional characteristics and clinical outcomes of critically ill patients with and without diabetes mellitus: a single-center prospective observational study in Malaysia |
| title | Nutritional characteristics and clinical outcomes of critically ill patients with and without diabetes mellitus: a single-center prospective observational study in Malaysia |
| title_full | Nutritional characteristics and clinical outcomes of critically ill patients with and without diabetes mellitus: a single-center prospective observational study in Malaysia |
| title_fullStr | Nutritional characteristics and clinical outcomes of critically ill patients with and without diabetes mellitus: a single-center prospective observational study in Malaysia |
| title_full_unstemmed | Nutritional characteristics and clinical outcomes of critically ill patients with and without diabetes mellitus: a single-center prospective observational study in Malaysia |
| title_short | Nutritional characteristics and clinical outcomes of critically ill patients with and without diabetes mellitus: a single-center prospective observational study in Malaysia |
| title_sort | nutritional characteristics and clinical outcomes of critically ill patients with and without diabetes mellitus: a single-center prospective observational study in malaysia |
| url | http://psasir.upm.edu.my/id/eprint/90277/ http://psasir.upm.edu.my/id/eprint/90277/ http://psasir.upm.edu.my/id/eprint/90277/1/15upm.pdf |