Paraneoplastic bullous pemphigoid masquerading as hand-foot syndrome: a case report of rare entity
Bullous pemphigoid (BP) is a chronic and the most frequent immune-mediated subepidermal blistering disorder which mainly affects elderly individuals. The autoantibodies produced following T-cell dysregulation are directed against BP180 (BPAg2) and BP230 (BPAg1), hemidesmosomal proteins located in th...
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| Format: | Article |
| Language: | English |
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Faculty of Medicine and Health Sciences, Universiti Putra Malaysia
2020
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| Online Access: | http://psasir.upm.edu.my/id/eprint/90201/ http://psasir.upm.edu.my/id/eprint/90201/1/20.pdf |
| _version_ | 1848861002900176896 |
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| author | Mohan, Subhatharshni Abdul Rahim, Nazatul Shima Salleh, Amizatul Aini Mahayidin, Hasni Bakrin, Ikmal Hisyam |
| author_facet | Mohan, Subhatharshni Abdul Rahim, Nazatul Shima Salleh, Amizatul Aini Mahayidin, Hasni Bakrin, Ikmal Hisyam |
| author_sort | Mohan, Subhatharshni |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Bullous pemphigoid (BP) is a chronic and the most frequent immune-mediated subepidermal blistering disorder which mainly affects elderly individuals. The autoantibodies produced following T-cell dysregulation are directed against BP180 (BPAg2) and BP230 (BPAg1), hemidesmosomal proteins located in the basement membrane zone (BMZ) of the epidermis. BP may present with polymorphic dermatological features including non-bullous manifestations and blisters. Therefore, a wide range of differential diagnoses such as eczema, urticaria, pemphigus and the differentials for subepidermal blister with eosinophils such as epidermolysis bullosa acquisita (EBA) and bullous drug eruptions should be considered in such cases. The associations of solid organ internal malignancies and BP are quite rare and vary between studies. Here, we present a case of paraneoplastic bullous pemphigoid (PNBP) in a patient with underlying renal cell carcinoma who was initially diagnosed with worsening hand-foot syndrome (HFS) which has led to withdrawal of his oral chemotherapy treatment. |
| first_indexed | 2025-11-15T12:54:13Z |
| format | Article |
| id | upm-90201 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T12:54:13Z |
| publishDate | 2020 |
| publisher | Faculty of Medicine and Health Sciences, Universiti Putra Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-902012021-09-09T21:22:28Z http://psasir.upm.edu.my/id/eprint/90201/ Paraneoplastic bullous pemphigoid masquerading as hand-foot syndrome: a case report of rare entity Mohan, Subhatharshni Abdul Rahim, Nazatul Shima Salleh, Amizatul Aini Mahayidin, Hasni Bakrin, Ikmal Hisyam Bullous pemphigoid (BP) is a chronic and the most frequent immune-mediated subepidermal blistering disorder which mainly affects elderly individuals. The autoantibodies produced following T-cell dysregulation are directed against BP180 (BPAg2) and BP230 (BPAg1), hemidesmosomal proteins located in the basement membrane zone (BMZ) of the epidermis. BP may present with polymorphic dermatological features including non-bullous manifestations and blisters. Therefore, a wide range of differential diagnoses such as eczema, urticaria, pemphigus and the differentials for subepidermal blister with eosinophils such as epidermolysis bullosa acquisita (EBA) and bullous drug eruptions should be considered in such cases. The associations of solid organ internal malignancies and BP are quite rare and vary between studies. Here, we present a case of paraneoplastic bullous pemphigoid (PNBP) in a patient with underlying renal cell carcinoma who was initially diagnosed with worsening hand-foot syndrome (HFS) which has led to withdrawal of his oral chemotherapy treatment. Faculty of Medicine and Health Sciences, Universiti Putra Malaysia 2020-11 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/90201/1/20.pdf Mohan, Subhatharshni and Abdul Rahim, Nazatul Shima and Salleh, Amizatul Aini and Mahayidin, Hasni and Bakrin, Ikmal Hisyam (2020) Paraneoplastic bullous pemphigoid masquerading as hand-foot syndrome: a case report of rare entity. Malaysian Journal of Medicine and Health Sciences, 16 (suppl. 9). pp. 127-130. ISSN 1675-8544; ESSN: 2636-9346 https://medic.upm.edu.my/upload/dokumen/2020110611242820_2020_0345.pdf |
| spellingShingle | Mohan, Subhatharshni Abdul Rahim, Nazatul Shima Salleh, Amizatul Aini Mahayidin, Hasni Bakrin, Ikmal Hisyam Paraneoplastic bullous pemphigoid masquerading as hand-foot syndrome: a case report of rare entity |
| title | Paraneoplastic bullous pemphigoid masquerading as hand-foot syndrome: a case report of rare entity |
| title_full | Paraneoplastic bullous pemphigoid masquerading as hand-foot syndrome: a case report of rare entity |
| title_fullStr | Paraneoplastic bullous pemphigoid masquerading as hand-foot syndrome: a case report of rare entity |
| title_full_unstemmed | Paraneoplastic bullous pemphigoid masquerading as hand-foot syndrome: a case report of rare entity |
| title_short | Paraneoplastic bullous pemphigoid masquerading as hand-foot syndrome: a case report of rare entity |
| title_sort | paraneoplastic bullous pemphigoid masquerading as hand-foot syndrome: a case report of rare entity |
| url | http://psasir.upm.edu.my/id/eprint/90201/ http://psasir.upm.edu.my/id/eprint/90201/ http://psasir.upm.edu.my/id/eprint/90201/1/20.pdf |