Prolonged neonatal jaundice with deranged thyroid function test
Congenital central hypothyroidism (CCH) is a rare disorder that results from deficient biosynthesis of thyroid hormone due to defective thyroid gland stimulation by thyroid stimulating hormone (TSH). Diagnosis is typically established biochemically by low free thyroxine (fT4) and inappropriately low...
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| Format: | Article |
| Language: | English |
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Faculty of Medicine and Health Sciences, Universiti Putra Malaysia
2020
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| Online Access: | http://psasir.upm.edu.my/id/eprint/90198/ http://psasir.upm.edu.my/id/eprint/90198/1/17.pdf |
| _version_ | 1848861002103259136 |
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| author | Choo, Jin Earn Chellappah Thambiah, Subashini Samsudin, Intan Nureslyna |
| author_facet | Choo, Jin Earn Chellappah Thambiah, Subashini Samsudin, Intan Nureslyna |
| author_sort | Choo, Jin Earn |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Congenital central hypothyroidism (CCH) is a rare disorder that results from deficient biosynthesis of thyroid hormone due to defective thyroid gland stimulation by thyroid stimulating hormone (TSH). Diagnosis is typically established biochemically by low free thyroxine (fT4) and inappropriately low or normal TSH levels after excluding all other causes of discordant thyroid function test (TFT). Here, we report a case of a baby girl who presented with prolonged jaundice at day 15 of life with normal cord blood TSH performed as routine screening for congenital hypothyroidism. Serial TFT revealed declining serum fT4 with normal TSH consistent with CCH. Her jaundice resolved prior to levothyroxine replacement. CCH is commonly missed on cord blood TSH-based newborn screening leading to a delay in diagnosis, potentially resulting in neurodevelopmental delay. Hence, although CCH has a lower incidence than congenital primary hypothyroidism, a high index of suspicion is essential for timely diagnosis. |
| first_indexed | 2025-11-15T12:54:12Z |
| format | Article |
| id | upm-90198 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T12:54:12Z |
| publishDate | 2020 |
| publisher | Faculty of Medicine and Health Sciences, Universiti Putra Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-901982021-09-09T11:29:55Z http://psasir.upm.edu.my/id/eprint/90198/ Prolonged neonatal jaundice with deranged thyroid function test Choo, Jin Earn Chellappah Thambiah, Subashini Samsudin, Intan Nureslyna Congenital central hypothyroidism (CCH) is a rare disorder that results from deficient biosynthesis of thyroid hormone due to defective thyroid gland stimulation by thyroid stimulating hormone (TSH). Diagnosis is typically established biochemically by low free thyroxine (fT4) and inappropriately low or normal TSH levels after excluding all other causes of discordant thyroid function test (TFT). Here, we report a case of a baby girl who presented with prolonged jaundice at day 15 of life with normal cord blood TSH performed as routine screening for congenital hypothyroidism. Serial TFT revealed declining serum fT4 with normal TSH consistent with CCH. Her jaundice resolved prior to levothyroxine replacement. CCH is commonly missed on cord blood TSH-based newborn screening leading to a delay in diagnosis, potentially resulting in neurodevelopmental delay. Hence, although CCH has a lower incidence than congenital primary hypothyroidism, a high index of suspicion is essential for timely diagnosis. Faculty of Medicine and Health Sciences, Universiti Putra Malaysia 2020-11 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/90198/1/17.pdf Choo, Jin Earn and Chellappah Thambiah, Subashini and Samsudin, Intan Nureslyna (2020) Prolonged neonatal jaundice with deranged thyroid function test. Malaysian Journal of Medicine and Health Sciences, 16 (suppl. 9). pp. 117-119. ISSN 1675-8544; ESSN: 2636-9346 https://medic.upm.edu.my/upload/dokumen/2020110611223317_2020_0248.pdf |
| spellingShingle | Choo, Jin Earn Chellappah Thambiah, Subashini Samsudin, Intan Nureslyna Prolonged neonatal jaundice with deranged thyroid function test |
| title | Prolonged neonatal jaundice with deranged thyroid function test |
| title_full | Prolonged neonatal jaundice with deranged thyroid function test |
| title_fullStr | Prolonged neonatal jaundice with deranged thyroid function test |
| title_full_unstemmed | Prolonged neonatal jaundice with deranged thyroid function test |
| title_short | Prolonged neonatal jaundice with deranged thyroid function test |
| title_sort | prolonged neonatal jaundice with deranged thyroid function test |
| url | http://psasir.upm.edu.my/id/eprint/90198/ http://psasir.upm.edu.my/id/eprint/90198/ http://psasir.upm.edu.my/id/eprint/90198/1/17.pdf |