Microglia-induced neurotoxicity: a review of in vitro co-culture models
Microglia-induced neurotoxicity occurs when inflammation mediated by microglia causes loss of neuronal structures or functions in the central nervous system implicated in stroke, spinal cord injury, sepsis, neurodegenerative diseases and even psychiatric illnesses. Various co-culture in vitro microg...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Faculty of Medicine and Health Sciences, Universiti Putra Malaysia
2020
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| Online Access: | http://psasir.upm.edu.my/id/eprint/90196/ http://psasir.upm.edu.my/id/eprint/90196/1/15upm.pdf |
| _version_ | 1848861001578971136 |
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| author | Ahmad Puzi, Nur Nabilah Vidyadaran, Sharmili |
| author_facet | Ahmad Puzi, Nur Nabilah Vidyadaran, Sharmili |
| author_sort | Ahmad Puzi, Nur Nabilah |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Microglia-induced neurotoxicity occurs when inflammation mediated by microglia causes loss of neuronal structures or functions in the central nervous system implicated in stroke, spinal cord injury, sepsis, neurodegenerative diseases and even psychiatric illnesses. Various co-culture in vitro microglia-induced neurotoxicity (MINT) models have been established to enable an in-depth study of this process and yet there is a dearth of information regarding usages, advantages and limitations of each of the components of this model. In this review, we examined 56 MINTs for the cells, stimuli, parameters, methods of neurotoxicity measurement and formats of co-culture used in their construction. We aim to provide foundational information, overall guideline and framework for the novice researcher to develop his/her own model and for the advancement of improved, novel and more representative MINT models. |
| first_indexed | 2025-11-15T12:54:11Z |
| format | Article |
| id | upm-90196 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T12:54:11Z |
| publishDate | 2020 |
| publisher | Faculty of Medicine and Health Sciences, Universiti Putra Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-901962021-09-09T11:23:58Z http://psasir.upm.edu.my/id/eprint/90196/ Microglia-induced neurotoxicity: a review of in vitro co-culture models Ahmad Puzi, Nur Nabilah Vidyadaran, Sharmili Microglia-induced neurotoxicity occurs when inflammation mediated by microglia causes loss of neuronal structures or functions in the central nervous system implicated in stroke, spinal cord injury, sepsis, neurodegenerative diseases and even psychiatric illnesses. Various co-culture in vitro microglia-induced neurotoxicity (MINT) models have been established to enable an in-depth study of this process and yet there is a dearth of information regarding usages, advantages and limitations of each of the components of this model. In this review, we examined 56 MINTs for the cells, stimuli, parameters, methods of neurotoxicity measurement and formats of co-culture used in their construction. We aim to provide foundational information, overall guideline and framework for the novice researcher to develop his/her own model and for the advancement of improved, novel and more representative MINT models. Faculty of Medicine and Health Sciences, Universiti Putra Malaysia 2020-11 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/90196/1/15upm.pdf Ahmad Puzi, Nur Nabilah and Vidyadaran, Sharmili (2020) Microglia-induced neurotoxicity: a review of in vitro co-culture models. Malaysian Journal of Medicine and Health Sciences, 16 (suppl. 9). pp. 97-113. ISSN 1675-8544; ESSN: 2636-9346 https://medic.upm.edu.my/upload/dokumen/2020110611212515_2020_0415.pdf |
| spellingShingle | Ahmad Puzi, Nur Nabilah Vidyadaran, Sharmili Microglia-induced neurotoxicity: a review of in vitro co-culture models |
| title | Microglia-induced neurotoxicity: a review of in vitro co-culture models |
| title_full | Microglia-induced neurotoxicity: a review of in vitro co-culture models |
| title_fullStr | Microglia-induced neurotoxicity: a review of in vitro co-culture models |
| title_full_unstemmed | Microglia-induced neurotoxicity: a review of in vitro co-culture models |
| title_short | Microglia-induced neurotoxicity: a review of in vitro co-culture models |
| title_sort | microglia-induced neurotoxicity: a review of in vitro co-culture models |
| url | http://psasir.upm.edu.my/id/eprint/90196/ http://psasir.upm.edu.my/id/eprint/90196/ http://psasir.upm.edu.my/id/eprint/90196/1/15upm.pdf |