Exploring the thumbprints of Ag-hydroxyapatite composite as a surface coating bone material for the implants
Polylactic acid (PLA), although has many interesting physicochemical characteristics, the strong hydrophobicity and a lack of antibacterial activity restricting its widespread application in the medical sector. In a view of addressing some of the limitations of PLA, the current study aimed to test t...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2020
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| Online Access: | http://psasir.upm.edu.my/id/eprint/88927/ http://psasir.upm.edu.my/id/eprint/88927/1/POLY.pdf |
| _version_ | 1848860729331941376 |
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| author | Lett, J. Anita Sagadevan, Suresh Paiman, Suriati Mohammad, Faruq Schirhag, Romana Léonard, Estelle Alshahateet, Solhe F. Oh, Won Chun |
| author_facet | Lett, J. Anita Sagadevan, Suresh Paiman, Suriati Mohammad, Faruq Schirhag, Romana Léonard, Estelle Alshahateet, Solhe F. Oh, Won Chun |
| author_sort | Lett, J. Anita |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Polylactic acid (PLA), although has many interesting physicochemical characteristics, the strong hydrophobicity and a lack of antibacterial activity restricting its widespread application in the medical sector. In a view of addressing some of the limitations of PLA, the current study aimed to test the antibacterial efficacy of active metal-doped bioceramic/PLA composite formed by the fused deposition manufacturing (FDM) technique. For the testing, we prepared polyvinyl alcohol (PVA) bound silver-hydroxyapatite (Ag-HAp) composite and further applied as a low-temperature coating onto the PLA scaffold designed for the appropriate cell development, differentiation, and bio-mineral establishment. From the analysis, we revealed that the larger surface area of three-dimensional (3D) printed composite material having the matrix porosity makes it a perfect biocompatible material with no loss to its mechanical potency. The HAp/PLA and Ag-HAp/PLA composites were tested for the hemocompatibility, and antibacterial activity (gram-positive and gram-negative bacteria). Further, the mechanical property of the Ag-HAp/PLA scaffold was tested. The results demonstrated that the Ag-HAp/PLA composite offers the biocompatibility and antibacterial ability and therefore can serve as the potential bone implant material. |
| first_indexed | 2025-11-15T12:49:52Z |
| format | Article |
| id | upm-88927 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T12:49:52Z |
| publishDate | 2020 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-889272021-10-04T21:54:34Z http://psasir.upm.edu.my/id/eprint/88927/ Exploring the thumbprints of Ag-hydroxyapatite composite as a surface coating bone material for the implants Lett, J. Anita Sagadevan, Suresh Paiman, Suriati Mohammad, Faruq Schirhag, Romana Léonard, Estelle Alshahateet, Solhe F. Oh, Won Chun Polylactic acid (PLA), although has many interesting physicochemical characteristics, the strong hydrophobicity and a lack of antibacterial activity restricting its widespread application in the medical sector. In a view of addressing some of the limitations of PLA, the current study aimed to test the antibacterial efficacy of active metal-doped bioceramic/PLA composite formed by the fused deposition manufacturing (FDM) technique. For the testing, we prepared polyvinyl alcohol (PVA) bound silver-hydroxyapatite (Ag-HAp) composite and further applied as a low-temperature coating onto the PLA scaffold designed for the appropriate cell development, differentiation, and bio-mineral establishment. From the analysis, we revealed that the larger surface area of three-dimensional (3D) printed composite material having the matrix porosity makes it a perfect biocompatible material with no loss to its mechanical potency. The HAp/PLA and Ag-HAp/PLA composites were tested for the hemocompatibility, and antibacterial activity (gram-positive and gram-negative bacteria). Further, the mechanical property of the Ag-HAp/PLA scaffold was tested. The results demonstrated that the Ag-HAp/PLA composite offers the biocompatibility and antibacterial ability and therefore can serve as the potential bone implant material. Elsevier 2020 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/88927/1/POLY.pdf Lett, J. Anita and Sagadevan, Suresh and Paiman, Suriati and Mohammad, Faruq and Schirhag, Romana and Léonard, Estelle and Alshahateet, Solhe F. and Oh, Won Chun (2020) Exploring the thumbprints of Ag-hydroxyapatite composite as a surface coating bone material for the implants. Journal of Materials Research and Technology, 9 (6). 12824 - 12833. ISSN 2238-7854 https://www.sciencedirect.com/science/article/pii/S2238785420317609 10.1016/j.jmrt.2020.09.037 |
| spellingShingle | Lett, J. Anita Sagadevan, Suresh Paiman, Suriati Mohammad, Faruq Schirhag, Romana Léonard, Estelle Alshahateet, Solhe F. Oh, Won Chun Exploring the thumbprints of Ag-hydroxyapatite composite as a surface coating bone material for the implants |
| title | Exploring the thumbprints of Ag-hydroxyapatite composite as a surface coating bone material for the implants |
| title_full | Exploring the thumbprints of Ag-hydroxyapatite composite as a surface coating bone material for the implants |
| title_fullStr | Exploring the thumbprints of Ag-hydroxyapatite composite as a surface coating bone material for the implants |
| title_full_unstemmed | Exploring the thumbprints of Ag-hydroxyapatite composite as a surface coating bone material for the implants |
| title_short | Exploring the thumbprints of Ag-hydroxyapatite composite as a surface coating bone material for the implants |
| title_sort | exploring the thumbprints of ag-hydroxyapatite composite as a surface coating bone material for the implants |
| url | http://psasir.upm.edu.my/id/eprint/88927/ http://psasir.upm.edu.my/id/eprint/88927/ http://psasir.upm.edu.my/id/eprint/88927/ http://psasir.upm.edu.my/id/eprint/88927/1/POLY.pdf |