Evaluation of the antigen relatedness and efficacy of a single vaccination with different infectious bronchitis virus strains against a challenge with Malaysian variant and QX-like IBV strains
Background: The predominant infectious bronchitis virus (IBV) strains detected in chickens in Malaysia are the Malaysian variant (MV) and QX-like, which are associated with respiratory distress, nephropathy, and high mortality. On the other hand, the antigenic relatedness and efficacy of IBV vaccine...
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| Format: | Article |
| Language: | English |
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Korean Society of Veterinary Science
2020
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| Online Access: | http://psasir.upm.edu.my/id/eprint/88876/ http://psasir.upm.edu.my/id/eprint/88876/1/VIRUS.pdf |
| _version_ | 1848860715789582336 |
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| author | Ismail, Mohd Iswadi Tan, Sheau Wei Bejo, Mohd Hair Omar, Abdul Rahman |
| author_facet | Ismail, Mohd Iswadi Tan, Sheau Wei Bejo, Mohd Hair Omar, Abdul Rahman |
| author_sort | Ismail, Mohd Iswadi |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | Background: The predominant infectious bronchitis virus (IBV) strains detected in chickens in Malaysia are the Malaysian variant (MV) and QX-like, which are associated with respiratory distress, nephropathy, and high mortality. On the other hand, the antigenic relatedness and efficacy of IBV vaccines against these 2 field IBV strains are not well characterized. Objectives: This study aimed to determine the antigen relatedness and efficacy of different IB vaccine strains against a challenge with MV and QX-like strains.
Methods: The antigen relatedness and the ability of different IB vaccine strains in conferring protection against MV and QX-like were assessed based on the clinical signs, macroscopic lesions, and ciliary activity. Results: The MV strain IBS037A/2014 showed minor antigenic subtype differences with the vaccine virus Mass H120 and 4/91 strains but showed major antigenic subtype differences with the K2 strain. The Malaysian QX-like strain IBS130/2015 showed major antigenic subtype differences with the MV strain IBS037A/2014 and the vaccine strains except for K2. Chickens vaccinated once with Mass (H120) or with non-Mass (4/91 and K2) developed antibody responses with the highest antibody titer detected in the groups vaccinated with H120 and 4/91. The mean ciliary activities of the vaccinated chickens were between 56 to 59% and 48 to 52% in chickens challenged with IBS037A/2014 and IBS130/2015, respectively. The vaccinated and challenged birds showed mild to severe lesions in the lungs and kidneys. Conclusions: Despite the minor antigenic subtype differences, a single inoculation with Mass or non-Mass vaccines could not protect against the MV IBS037A/2014 and QX-like IBS130/2015. |
| first_indexed | 2025-11-15T12:49:39Z |
| format | Article |
| id | upm-88876 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T12:49:39Z |
| publishDate | 2020 |
| publisher | Korean Society of Veterinary Science |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-888762021-10-05T00:14:28Z http://psasir.upm.edu.my/id/eprint/88876/ Evaluation of the antigen relatedness and efficacy of a single vaccination with different infectious bronchitis virus strains against a challenge with Malaysian variant and QX-like IBV strains Ismail, Mohd Iswadi Tan, Sheau Wei Bejo, Mohd Hair Omar, Abdul Rahman Background: The predominant infectious bronchitis virus (IBV) strains detected in chickens in Malaysia are the Malaysian variant (MV) and QX-like, which are associated with respiratory distress, nephropathy, and high mortality. On the other hand, the antigenic relatedness and efficacy of IBV vaccines against these 2 field IBV strains are not well characterized. Objectives: This study aimed to determine the antigen relatedness and efficacy of different IB vaccine strains against a challenge with MV and QX-like strains. Methods: The antigen relatedness and the ability of different IB vaccine strains in conferring protection against MV and QX-like were assessed based on the clinical signs, macroscopic lesions, and ciliary activity. Results: The MV strain IBS037A/2014 showed minor antigenic subtype differences with the vaccine virus Mass H120 and 4/91 strains but showed major antigenic subtype differences with the K2 strain. The Malaysian QX-like strain IBS130/2015 showed major antigenic subtype differences with the MV strain IBS037A/2014 and the vaccine strains except for K2. Chickens vaccinated once with Mass (H120) or with non-Mass (4/91 and K2) developed antibody responses with the highest antibody titer detected in the groups vaccinated with H120 and 4/91. The mean ciliary activities of the vaccinated chickens were between 56 to 59% and 48 to 52% in chickens challenged with IBS037A/2014 and IBS130/2015, respectively. The vaccinated and challenged birds showed mild to severe lesions in the lungs and kidneys. Conclusions: Despite the minor antigenic subtype differences, a single inoculation with Mass or non-Mass vaccines could not protect against the MV IBS037A/2014 and QX-like IBS130/2015. Korean Society of Veterinary Science 2020 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/88876/1/VIRUS.pdf Ismail, Mohd Iswadi and Tan, Sheau Wei and Bejo, Mohd Hair and Omar, Abdul Rahman (2020) Evaluation of the antigen relatedness and efficacy of a single vaccination with different infectious bronchitis virus strains against a challenge with Malaysian variant and QX-like IBV strains. Journal of Veterinary Science, 21 (6). pp. 1-13. ISSN 1229-845X; ESSN: 1976-555X https://www.vetsci.org/DOIx.php?id=10.4142/jvs.2020.21.e76 10.4142/jvs.2020.21.e76 |
| spellingShingle | Ismail, Mohd Iswadi Tan, Sheau Wei Bejo, Mohd Hair Omar, Abdul Rahman Evaluation of the antigen relatedness and efficacy of a single vaccination with different infectious bronchitis virus strains against a challenge with Malaysian variant and QX-like IBV strains |
| title | Evaluation of the antigen relatedness and efficacy of a single vaccination with different infectious bronchitis virus strains against a challenge with Malaysian variant and QX-like IBV strains |
| title_full | Evaluation of the antigen relatedness and efficacy of a single vaccination with different infectious bronchitis virus strains against a challenge with Malaysian variant and QX-like IBV strains |
| title_fullStr | Evaluation of the antigen relatedness and efficacy of a single vaccination with different infectious bronchitis virus strains against a challenge with Malaysian variant and QX-like IBV strains |
| title_full_unstemmed | Evaluation of the antigen relatedness and efficacy of a single vaccination with different infectious bronchitis virus strains against a challenge with Malaysian variant and QX-like IBV strains |
| title_short | Evaluation of the antigen relatedness and efficacy of a single vaccination with different infectious bronchitis virus strains against a challenge with Malaysian variant and QX-like IBV strains |
| title_sort | evaluation of the antigen relatedness and efficacy of a single vaccination with different infectious bronchitis virus strains against a challenge with malaysian variant and qx-like ibv strains |
| url | http://psasir.upm.edu.my/id/eprint/88876/ http://psasir.upm.edu.my/id/eprint/88876/ http://psasir.upm.edu.my/id/eprint/88876/ http://psasir.upm.edu.my/id/eprint/88876/1/VIRUS.pdf |