Ethnicity as predictor of immune reconstitution among Malaysian HIV‐positive patients treated with highly active antiretroviral therapy
The impact of sociodemographic and clinical factors on immune recovery and viral load suppression among HIV-1 positive patients treated with HAART particularly in Malaysia is largely unknown. This cross-sectional study enrolled 170 HIV-1-infected individuals of three major ethnicities who attended t...
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| Format: | Article |
| Language: | English |
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John Wiley & Sons
2020
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| Online Access: | http://psasir.upm.edu.my/id/eprint/88853/ http://psasir.upm.edu.my/id/eprint/88853/1/ABSTRACT.pdf |
| _version_ | 1848860709769707520 |
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| author | Mohamad Isa, Irma Izani Abu Bakar, Suhaili Ab Rahman, Ahmad Kashfi |
| author_facet | Mohamad Isa, Irma Izani Abu Bakar, Suhaili Ab Rahman, Ahmad Kashfi |
| author_sort | Mohamad Isa, Irma Izani |
| building | UPM Institutional Repository |
| collection | Online Access |
| description | The impact of sociodemographic and clinical factors on immune recovery and viral load suppression among HIV-1 positive patients treated with HAART particularly in Malaysia is largely unknown. This cross-sectional study enrolled 170 HIV-1-infected individuals of three major ethnicities who attended three HIV outpatient clinics in Malaysia. Questionnaire was used to obtain sociodemographic data while CD4 count and viral load data were gathered from hospital's record. Multiple factors were assessed for their predictive effects on CD4 count recovery (≥500 cells/mm3 ) and viral load suppression (≤50 copies/mL) using binary logistic regression. Most of the subjects were male (149/87.6%), in the age group 30 to 39 years old (78/45.9%) and got infected via homosexual contact (82/48.2%). Indians were associated with 11 times higher chance for CD4 recovery as compared to Malays at 8 to 12 months of HAART (adjusted OR: 10.948, 95% CI: 1.873, 64.001, P = .008). Viral load suppression was positively influenced by intravenous drug use (IVDU) status (adjusted OR: 35.224, 95% CI: 1.234, 1000.489, P = .037) at 4 to 6 months of HAART. Higher pretreatment CD4 count was a positive predictor for both initial immunological and virological responses while higher pretreatment viral load was a negative predictor for virological suppression only. In conclusion, ethnicity plays a significant role in determining early immune reconstitution in Malaysia, besides pretreatment CD4 count. Further studies are needed to identify possible biological factors underlying this association. |
| first_indexed | 2025-11-15T12:49:33Z |
| format | Article |
| id | upm-88853 |
| institution | Universiti Putra Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-15T12:49:33Z |
| publishDate | 2020 |
| publisher | John Wiley & Sons |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | upm-888532021-10-07T03:15:47Z http://psasir.upm.edu.my/id/eprint/88853/ Ethnicity as predictor of immune reconstitution among Malaysian HIV‐positive patients treated with highly active antiretroviral therapy Mohamad Isa, Irma Izani Abu Bakar, Suhaili Ab Rahman, Ahmad Kashfi The impact of sociodemographic and clinical factors on immune recovery and viral load suppression among HIV-1 positive patients treated with HAART particularly in Malaysia is largely unknown. This cross-sectional study enrolled 170 HIV-1-infected individuals of three major ethnicities who attended three HIV outpatient clinics in Malaysia. Questionnaire was used to obtain sociodemographic data while CD4 count and viral load data were gathered from hospital's record. Multiple factors were assessed for their predictive effects on CD4 count recovery (≥500 cells/mm3 ) and viral load suppression (≤50 copies/mL) using binary logistic regression. Most of the subjects were male (149/87.6%), in the age group 30 to 39 years old (78/45.9%) and got infected via homosexual contact (82/48.2%). Indians were associated with 11 times higher chance for CD4 recovery as compared to Malays at 8 to 12 months of HAART (adjusted OR: 10.948, 95% CI: 1.873, 64.001, P = .008). Viral load suppression was positively influenced by intravenous drug use (IVDU) status (adjusted OR: 35.224, 95% CI: 1.234, 1000.489, P = .037) at 4 to 6 months of HAART. Higher pretreatment CD4 count was a positive predictor for both initial immunological and virological responses while higher pretreatment viral load was a negative predictor for virological suppression only. In conclusion, ethnicity plays a significant role in determining early immune reconstitution in Malaysia, besides pretreatment CD4 count. Further studies are needed to identify possible biological factors underlying this association. John Wiley & Sons 2020 Article PeerReviewed text en http://psasir.upm.edu.my/id/eprint/88853/1/ABSTRACT.pdf Mohamad Isa, Irma Izani and Abu Bakar, Suhaili and Ab Rahman, Ahmad Kashfi (2020) Ethnicity as predictor of immune reconstitution among Malaysian HIV‐positive patients treated with highly active antiretroviral therapy. Journal of Medical Virology, 92 (8). 1173 - 1181. ISSN 0146-6615; ESSN: 1096-9071 https://onlinelibrary.wiley.com/doi/10.1002/jmv.25680 10.1002/jmv.25680 |
| spellingShingle | Mohamad Isa, Irma Izani Abu Bakar, Suhaili Ab Rahman, Ahmad Kashfi Ethnicity as predictor of immune reconstitution among Malaysian HIV‐positive patients treated with highly active antiretroviral therapy |
| title | Ethnicity as predictor of immune reconstitution among Malaysian HIV‐positive patients treated with highly active antiretroviral therapy |
| title_full | Ethnicity as predictor of immune reconstitution among Malaysian HIV‐positive patients treated with highly active antiretroviral therapy |
| title_fullStr | Ethnicity as predictor of immune reconstitution among Malaysian HIV‐positive patients treated with highly active antiretroviral therapy |
| title_full_unstemmed | Ethnicity as predictor of immune reconstitution among Malaysian HIV‐positive patients treated with highly active antiretroviral therapy |
| title_short | Ethnicity as predictor of immune reconstitution among Malaysian HIV‐positive patients treated with highly active antiretroviral therapy |
| title_sort | ethnicity as predictor of immune reconstitution among malaysian hiv‐positive patients treated with highly active antiretroviral therapy |
| url | http://psasir.upm.edu.my/id/eprint/88853/ http://psasir.upm.edu.my/id/eprint/88853/ http://psasir.upm.edu.my/id/eprint/88853/ http://psasir.upm.edu.my/id/eprint/88853/1/ABSTRACT.pdf |